Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"inhibitory balance"”.
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… in ambient glutamate levels and/or a redox imbalance involving GSH have been reported to affect synaptic strength and intrinsic neuronal excitability, the main focus of this dissertation was to elucidate whether Sxc- signaling contributes to brain excitatory/inhibitory (E/I) balance in vivo. …
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Synaptic Excitatory to Inhibitory imbalance in Alzheimer’s Disease
… abnormalities that disturb the excitatory/inhibitory balance (E/I ratio) in circuits vulnerable to Alzheimer’s disease pathology. We measured electrophysiological, anatomical, transcriptional, and cellular E/I ratios in human brain. Our findings establish a strong correlational link between …
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State Space Methods Using Biologically-Relevant Generative Models to Analyze Neural Signals
… have been developed to identify excitatory-inhibitory balance in the LFP or ECoG, but are not defined in terms of a generative model. Here we present three novel methods that utilize generative models to (1) identify and characterize neural oscillations distinct from broad-band noise (2) …
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The role of fast-spiking interneurons in cortical map plasticity
… in inhibition to re-establish the excitatory – inhibitory balance. These hypotheses make different predictions about how inhibition<br/>changes during cortical map plasticity, which I have tested in this thesis. I focused on fast-spiking (FS) interneurons, which are thought to play an important …
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An electrophysiological basis for human memory
… predictions about dynamic excitatory and inhibitory balance during spiking sequences in the human data. Taken together, our results demonstrate a flexible mode of communication between the MTL and cortex in the service of episodic memory, and we provide a theoretical framework for …
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Electrophysiological Markers of Sensory Plasticity and Connectomics in Ageing and Mild Cognitive Impairment
… by a specific disruption of the excitatory-inhibitory balance within sensory processing regions, and disrupted ERPs. Importantly, both paradigms afforded a unique perspective on this disruption. The results of this thesis not only shed light on how the brain learns, but also demonstrate the …
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Interaction of Quantal Inhibitory and Excitatory Neurotransmission in Regulation of Synaptic Homeostasis via Molecular Signaling
… done in excitatory synapses. Yet the variety of inhibitory neurons is so vast that Ramon y Cajal referred to them as the "Butterflies of the Soul." In order to help paint a more complete picture of the brain, this PhD thesis is focused on the structure, function, and regulation of synapses and …
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Analyzing the Dynamics of Biological and Artificial Neural Networks with Applications to Machine Learning
… by exploring the concept of excitatory-inhibitory balance, a crucial feature of neuronal networks in the brain, within the framework of reservoir computing. We emphasize the stabilizing role of inhibition in reservoir computers (RCs), mirroring its function in the brain. We propose a …
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The gut microbiome: a contributing mechanism to the anti-seizure effect of topiramate
… drugs, which aim to restore the excitatory and inhibitory balance in the brain. Unfortunately, about 30% of people with epilepsy are drug resistant, a number which has remained unchanged despite the increasing amount of anti-epileptic drugs. This leads patients to seek alternative treatments, …
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Dynamical Systems Analysis of Neural Circuits with Applications to Physiological Processes
… how external input and intrinsic excitatory–inhibitory balance control the emergence of oscillatory activity in the circuit and shape the MePD output that acts downstream of the GnRH pulse generator. In contrast to earlier assumptions of constant MePD output, the model establishes the …
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ROLE OF ATM IN THE PATHOPHYSIOLOGY OF MAJOR DEPRESSIVE DISORDER (MDD)
… neurotransmitter release, excitatory/inhibitory balance maintenance, the development of GABAergic system and neuroinflammation. Mutations in ATM cause Ataxia-telangiectasia (A-T), a syndrome characterized by devastating neurological symptoms ascribable primarily to cerebellar …
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Heterogenous Change in Neuronal Bursts Following Recovery from Activity Silencing
Silencing of activity in hippocampal neuronal cultures was used to study how dynamic neuronal activity achieves a state of homeostasis, using calcium imaging to detect neuronal firing patterns. Recovering cultures were found to display abnormal activity patterns after 48hrs of exposure to …