Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2535 for “"inhibitory"”.
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Aging and inhibitory control
… in working memory capacity, and a loss of inhibitory control. Although not inherently incompatible, each of the theories provides a unique interpretation of the observed pattern of psychological and neuronal data. To test the veracity of the inhibitory theory a series of experiments was …
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… In this thesis, I characterized a potent inhibitory phenotype of murine OPC adhesion and process outgrowth cultured on CSPGs in vitro. I explored the various mechanisms underlying this inhibitory response, including candidate receptors, downstream signalling molecules, and structural …
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Polarised secretion of leukaemia inhibitory factor
Leukaemia inhibitory factor (LIF) is a cytokine that is active on a wide variety of cells. Multiple LIF transcripts have been described. The transcripts LIF-D and LIF-M encode different signal peptides, which in mouse have been associated with differential localisation of the mature protein. LIF-D …
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Inhibitory Control of Muscle Activity in Sleep
In this thesis, I examined the inhibitory control of REM sleep motor activity using both a pharmacological rat model and a genetic mouse model. I characterized the role for GABA and glycine in mediating the REM-specific suppression of muscle activity as well as their involvement in regulating the …
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Neurologin Function in Excitatory and Inhibitory Synapses
… abolished the change of the evoked and miniature inhibitory responses from the NL2 wild type, which suggested the inhibitory responses triggered by NL2 go through NRXs. And the slight change of the paired pulse ratio suggested the change of presynaptic calcium through binding. The study suggested …
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Inhibitory Fields in the Limulus Lateral Eye
<p>Spatial distribution of the inhibitory influences exerted by ommatidia in the Limulus lateral eye was measured. The source of inhibition was a small cluster of ommatidia illuminated through a flexible bundle of glass fibers ("fiber optics"). The inhibitory field of the cluster was determined by …
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Neuromodulation of Inhibitory Activity in Thalamocortical Circuits
In last chapter, I demonstrate that the inhibitory currents arising from interneurons and TRN neurons can be distinguished by their kinetics. The local interneurons are of interest because these neurons have two distinct outputs: axonal and dendritic. These cells have classical axonal outputs, …
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Inhibitory Control of Regeneration in Nemertean Worms
Made available in DSpace on 2014-12-04T22:46:11Z (GMT). No. of bitstreams: 1 6000247.pdf: 1808422 bytes, checksum: eb124b543f06ef9ea47a324c1a4fb2be (MD5) Previous issue date: 1959
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Synaptic Excitatory to Inhibitory imbalance in Alzheimer’s Disease
… abnormalities that disturb the excitatory/inhibitory balance (E/I ratio) in circuits vulnerable to Alzheimer’s disease pathology. We measured electrophysiological, anatomical, transcriptional, and cellular E/I ratios in human brain. Our findings establish a strong correlational link between …
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Visualizing inhibitory and excitatory synapse dynamics In vivo
… we now know that even in the mature brain inhibitory or excitatory connections can be made and broken, modifying the information flow within a circuit by enabling or removing specific information channels. However, the properties of inhibitory and excitatory synapse dynamics are not well …
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A Multimodal Investigation of Age Differences in Inhibitory Control
… domains of cognitive control: working memory, inhibitory control, and updating ability. White matter microstructure (i.e., fractional anisotropy, FA) was associated with age-related reductions in response inhibition, as assessed by the go/no-go task. Based on the notion that brain function is …
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Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
… types. To this end, I examined the regulation of inhibitory neurons and their synapses. I used chronic pharmacological block of activity in a neocortical slice cultures to examine the role activity plays in regulating feedback inhibition defined by two biochemical inhibitory neuron subtypes - …
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Inhibitory Control of Contextual Fear Memory and Memory Specificity
… in the brain is mainly achieved by GABAergic inhibitory neurons which exert their effect by acting on multiple types of GABA receptors. In this dissertation, I examined the roles of specific types of GABAergic neurons and GABA receptors in learning and memory. The study consists of three major …
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The Inhibitory Effects of Acetic Acid on Enteric Bacteria
The surface of a multicellular organism, exposed to the external environment, either directly or indirectly, is inhabited by a specific microbial flora. This holds true regardless of the species or environment of the multicellular organism's The microbial flora of the multicellular organism, man, …
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Role for Macrophage Migration Inhibitory Factor in Multiple Sclerosis
Il fattore di inibizione della migrazione dei macrofagi (MIF) è una citochina proinfiammatoria che svolge un ruolo importante nella patogenesi di numerosi disordini infiammatori e autoimmuni. Come tale, è un obiettivo terapeutico interessante per il trattamento di questi disturbi. Diversi dati …
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Expression of Macrophage Migration Inhibitory Factor in Behçet's disease
PURPOSE: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-173 G>C polymorphism or the MIF-794 [CATT]5-8 polymorphism and haplotypes containing these variants were associated with an …
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