Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"inhibitor-resistant"”.
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The Molecular Basis of Fitness and Transmissibility of Neuraminidase Inhibitor Resistant Influenza A Viruses
<p>Neuraminidase (NA) inhibitors including oral oseltamivir and inhaled zanamivir are among the first line of defense against influenza virus infection. Development of resistance to NA inhibitors is a huge drawback for limited options for the control of influenza. During the first decade of NA …
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Role of C-Met and Egfr In Acquired Resistance to Parp Inhibitors In Triple-Negative Breast Cancer
… limited. The Poly (ADP-ribose) polymerase (PARP) inhibitors, olaparib and talazoparib, were recently approved for metastatic breast cancer (including triple-negative breast cancer) in patients with a germline <em>BRCA1/2</em> mutation. Despite impressive response rates of ~60%, the prolongation in …
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INHIBITOR RESISTANCE MECHANISMS AND INHIBITOR DESIGN IN ¿¿-LACTAMASES
… design of new and highly effective ¿¿-lactamase inhibitors. This in turn will prolong the efficacy of existing ¿¿-lactams. Likewise, because ¿¿-lactamase inhibitors have high structural similarity to ¿¿-lactams, information gleaned from the study of the former will inform on the design of the …
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Weed Control in Cucumber Cucumis sativus, Pumpkin Cucurbita maxima, and Summer Squash Cucurbita pepo with Halosulfuron
… of acetolactate synthase inhibiting (ALS) resistant smooth pigweed to postemergence halosulfuron was also investigated. Halosulfuron activity against ALS-inhibitor resistant smooth pigweed was population dependent. In the greenhouse, postemergence halosulfuron at the same rates used in the …
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Multiple Herbicide Resistance in Waterhemp
… treatment of several acetolactate synthase (ALS) inhibitors, and a POST application of lactofen, a protoporphyrinogen oxidase (PPO)-inhibiting herbicide. Greenhouse studies were conducted with this waterhemp biotype, and revealed that plants were also resistant to atrazine, a photosystem II …
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Crop and herbicide rotation effects on weed population dynamics and the characterization of imidazolinone-resistant smooth pigweed (Amaranthus hybridus)
Shifts in weed populations to herbicide-resistant biotypes are occurring more frequently. In two adjacent field studies from 1991 through 1994, crop rotations and herbicide programs affected control and densities of common lambsquarters, common ragweed, smooth pigweed, redroot pigweed, jimsonweed, …
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Characterization of HPPD-inhibitor resistance in waterhemp (Amaranthus tuberculatus)
… a review of the literature pertaining to HPPD inhibitors, namely their discovery and uses as herbicides, as well as a section on waterhemp biology. Chapter 2 discusses the initial greenhouse research used to determine if the waterhemp population from McLean Co. (designated MCR) had indeed …
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Mechanisms and control of waterhemp populations resistant to group 15 herbicides
… and reduce seed yield potential. Waterhemp is resistant to herbicides from seven site-of-action groups, with resistance to VLCFA-inhibiting herbicides the most recently evolved. Control of two Illinois waterhemp populations (CHR and MCR) with the VLCFA inhibitor S-metolachlor was much less than …
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
… not yet been shown to be actionable by precision inhibitors. This thesis hypothesised that fluorescence in-situ hybridisation (FISH) would be an accurate, efficient and practical method for diagnosis of Ph-like ALL genomic lesions in the real-world. Based on current literature, it was postulated …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… two series of putative trypanosomal PDE inhibitors, from different sources, were thoroughly assessed in this project for their anti-trypanosomal activity and their intracellular effects on the trypanosome. The whole-cell in vitro efficacy for each compound, against T. brucei wildtype and …
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A multiplexed approach for quantitative profiling of the translatome using bioorthogonal non-canonical amino acids
… to compare the translation response between MEK inhibitor resistant (MelJuso) and sensitive (MM415) melanoma cell lines. Using partial least squares regression (PLSR) and gene set enrichment analysis (GSEA), upregulation of melanoma lineage-dependent transcription factor MITF and MITF targets was …
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From Mechanisms of Leukaemogenic Dysregulation to New Candidate Therapeutics
… consistent molecular changes characteristic of resistant cells. Intratumoural heterogeneity underpins resistance to cancer therapies through both genetic and non-genetic means. Long term exposure of ME-Transformed cells to single small molecule inhibitory agents targeting the kinase activity of …
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Development of BMP type I receptor kinase inhibitors for the treatment of fibrodysplasia ossificans progressiva and the study of the BMP signaling pathway
… highly selective BMP type I receptor inhibitors targeting ALK2 for the treatment of FOP. Despite the high degree of structural homology between all the BMP and TGF-[beta] type I receptors, I hypothesized that potent and selective inhibitors targeting a single BMP type I receptor, ALK2, …