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Showing 1 to 20 of 47 for “"inhibitor of apoptosis"”.
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
… biochemical and cellular changes. Resistance to apoptosis is one of the characteristics of cancer, of which the inhibitor of apoptosis (IAP) family of proteins plays an important role. It has also been shown that cancer cells secrete vesicles called tumor exosomes (TEX) which are loaded with …
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Expression of X-linked Inhibitor of Apoptosis Protein in Neoplastic Thyroid Disorder
X-linked inhibitor of apoptosis protein (XIAP) is associated with tumor genesis, growth, progression and metastasis, and acts by blocking caspase-mediated apoptosis. In the present study, we sought to evaluate the expression patterns of XIAP in various neoplastic thyroid disorders and determine the …
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Investigating the Role of the Inhibitor of Apoptosis Proteins (IAPs) in Metastasis Formation
Inhibitor of apoptosis proteins (IAPs) constitute a conserved family of molecules, which regulate both apoptosis and receptor signalling. They are often deregulated in cancer cells and represent potential targets for therapy. In my work, I investigated the effect of IAP inhibition <i>in vivo</i> to …
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Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
<p>Apoptotic dysregulation is a hallmark of cancer cells. The inability of cancer cells to undergo apoptosis may lead to therapeutic resistance. Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer that is often characterized by ErbB2 overexpression and ErbB2 activation. …
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Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury.
… disorder which results in the selective loss of the medium spiny neurons in the striatum. The neuropathological and behavioural deficits of HD can be modeled in rats by injection of the NMDA receptor agonist quinolinic acid (2,3 pyridine decarboxylate; QA) directly into the striatum. The first …
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THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN INCREASES P34CDC2 PHOSPHORYLATION AND ENHANCES CELL SURVIVAL AND PROLIFERATION BY PROTECTING THE WEE1 KINASE FROM DEGRADATION BY CASPASE-3
… are involved in cell cycle progression and apoptosis. Activation of Cdc2 is required for its pro-apoptotic activity, which can be inhibited by phosphorylation at Tyrosine-15 (Tyr15). In transduced IL-3-dependent murine BaF3 hematopoietic cells, over-expression of wild-type-(wt)-Survivin …
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Baculovirus inhibitors of apoptosis
A putative inhibitor of apoptosis gene was located in the Heliothis zea nucleopolyhedrovirus (HzSNPV) genome, at map units 76 to 77. Alignment of the predicted amino sequence encoded by this gene with reported inhibitor of apoptosis (iap) sequences identifted a RING finger and baculovirus IAP …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
Cells may die via a programmed cell death called apoptosis. Apoptosis can be triggered by many death signals, some of which cause cytochrome c to be released from the mitochondria initiating the caspase cascade. When there is an over-expression of Heat Shock Protein 27 (HSP27), the cell does not …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
… disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the susceptibility to iron-induced lipid peroxidation was enhanced. This resulted in ferroptosis as cell death was …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… compounds (SMCs) are small molecule antagonists of the Inhibitor of Apoptosis (IAP) family of proteins. Binding of SMCs to the IAPs results in the sensitization of cancer cells to apoptosis in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize that type I …
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Calpain 9 Functions in TNF Receptor Mediated Apoptosis
Evasion of apoptosis is a hallmark of cancer development. The Inhibitor of Apoptosis Proteins, IAPs, block Caspase activity and cell death. Release of the Second Mitochondria-Derived Activator of Caspases, Smac, from the mitochondria relieves IAP Caspase inhibition, activating apoptosis. Our lab …
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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors
<p>Tubulin inhibitors are widely used as chemotherapeutic agents, and their successis attributed to their ability to target microtubule dynamics and disrupt critical cellular functions including cell signaling, motility, intracellular trafficking, and mitosis. Interference with microtubule dynamics …
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Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
Inhibitor of apoptosis proteins (IAPs) regulates apoptosis by inhibiting caspases. This inhibition mechanism is an escape from death used by some human cancers. Second mitochondria-derived activator of caspases (Smac), a mitochondria-released protein during apoptosis, binds to IAPs BIR domains with …
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Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to develop a [superscript 177]Lu-labeled bcl-2 antisense peptide nucleic …
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Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
… kinase, ATM, CHK2 phosphorylates a wide variety of down stream effectors to promote cell cycle arrest, DNA repair and apoptosis. One of they key downstream substrate of CHK2 is the tumor suppressor protein, p53. CHK2 is considered as a key kinase in DNA damage-induced p53 regulation and thought …
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A Study to Investigate Factors Involved in the Development of Oesophageal Carcinoma
… compared to reflux patients without evidence of Barrett's oesophagus.<br/><br/>Bcl-2 is an inhibitor of apoptosis or programmed cell death and bax is a promoter. p53 is a protein regulating these. Studies have shown a bcl-2/bax ratio favouring bax expression to be predictive of a good response …
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Is It Memory or Is It Death? Caspase-3 and Memory Formation
… Stroke, Alzheimer's and Parkinson's. Activation of caspase-3 is normally thought of as the terminal step in the biochemical cascade of apoptosis (programmed cell death). However, it is present in healthy adult neurons. Is it being expressed, potentially for decades, by these healthy cells in …
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