Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"inhibition mechanisms"”.
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Investigations of the inhibition mechanisms of human ribonucleotide reductase by gemcitabine-5'-diphosphate and saccharomyces cerevisiae ribonucleotide reductase by Sml1
… second part of this thesis focuses on the Sml inhibition mechanism in S. cerevisiae. Smll is a 12 kDa small protein RNR inhibitor.
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High-Throughput Profilometric Screening of Corrosion Inhibitors and Molecular Structure Effects on Magnesium Alloy Protection
… how functional groups influence the corrosion inhibition mechanisms of Mg alloys. Insights into the relationship between molecular structure and inhibition performance can guide the selection and design of effective corrosion inhibitors tailored for specific environmental conditions.
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Characterizing biological nitrification inhibition using native Nitrosomonas europaea: mechanism studies and maize cultivar screening
… a phenomenon called Biological Nitrification Inhibition (BNI). BNI chemicals disrupt the enzymatic pathways required for nitrification; however, the precise inhibition mechanisms and their impacts on N. europaea remain poorly understood. Previous studies have primarily focused on quantifying …
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The neurophysiology of internally-driven actions
… control. In the scientific literature, action inhibition is often treated as a unitary phenomenon, while the distinction among different types of inhibitions might explain the diverse results and be useful for future studies. My experimental work has been devoted to both externally-triggered …
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On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine
… and in cell regulation. Understanding inhibition mechanisms of kinases is important for the further development of new therapies for cancer and inflammatory diseases. I have developed a statistical approach based on the Mantel test to find the relationship between the shapes of ATP …
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Erosion-corrosion mitigation using chemicals
… Although research into corrosion inhibition has been extensively conducted, there is less documentation of inhibitors in retarding erosion-corrosion. This thesis has attempted to construct a quantitative structure relationship between erosion, corrosion and their synergistic …
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Revitalizing Simulations of Colloidal and Interfacial Systems: From Atomistic Trajectories to Data-Centric Insights
… challenges in water-in-oil emulsions, chemical inhibition in asphaltene aggregation, and adsorption energy prediction. While each theme addresses unique challenges, they all contribute to quantitative understanding of interactions across scales, integrating structural, thermodynamic, and …
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Implementation of Acid/Gas Digestion Approach to Maximize Volatile Fatty Acids Production from Municipal Sludge and a Techno-economic Feasibility Study
… contact time (0-10 days), while simultaneously inhibition mechanisms on VFAs production were investigated. Once the optimum operating conditions for VFAs production were determined, thermophilic (50°C) semi-continuous acid digesters were operated at three different solids retention times (SRTs) …
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Design, development, and evaluation of novel polymer-drug conjugates and interpolymer complexes for the treatment of neurodegenerative disease.
… was performed to determine cholinesterase inhibition mechanisms. NM15 (unadjusted and adjusted value) showed significantly enhanced antioxidant activity (p ≤ 0.0001) compared to vanillin. The adjusted value of N5 showed significantly greater AChE and BuChE inhibition (p ≤ 0.0001) compared …
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Molecular interactions and their impact on life sciences
… In contrast to the specific secondary nucleation inhibition by Brichos, clusterin inhibits specifically fibril elongation of amyloid-beta. I could show that these two specific aggregation processes are affected by the two chaperones, Brichos and clusterin, in a non-cooperative manner. These …
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Optimization of Biological Nitrogen Removal From Fermented Dairy Manure Using Low Levels of Dissolved Oxygen
… half saturation coefficient, . Nitrifying inhibition terms of competitive, non-competitive, mixed competitive, and un-competitive were applied to the growth rate equation in BioWin® but an accurate representation of the observed TAN removal rates in the pilot scale system could not be found …
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Neural Dynamics of Goal-Directed Action Selection: A Multivariate Approach to Evidence Accumulation and Cognitive Control in Response to Competing Stimuli
… perception to action is resolved: though the inhibition of task-irrelevant information, the enhancement of relevant information, or a combination of both. In Chapter 3, I developed variations of the classic Stroop task suitable for a subsequent fMRI investigation to detect neural processes of …