Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"inhibition mechanism"”.
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Electrophysiological indices of the violence inhibition mechanism and their associations with physical agression, callous-unemotional traits, and dietary omega-3
… is importance for understanding the underlying mechanisms of aggression and how it might best be managed. The violence inhibition mechanism, thought to be dysfunctional in individuals characterised by aggressive behaviour and associated callous-unemotional traits, is used to explain how the …
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EXPLORING THE ALLOSTERIC INHIBITION MECHANISM OF HUMAN KIDNEY TYPE GLUTAMINASE TO ARREST CANCER CELL PROLIFERATION AND INVESTIGATING HAKAI MEDIATED UBIQUITINATION TOWARDS CONTROLLING CANCER CELL MIGRATION
The development and progression of cancer can be associated with certain hallmarks. Two among them are the altered cell metabolism (Warburg effect), and cancer cell invasion/progression mediated by post-translational modulation of cell signaling. In this thesis we have attempted to explore these …
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Direct Precipitation of Micron-Size Salbutamol Sulphate by Antisolvent Crystallization
… showed the strongest effect on crystal growth inhibition. By adding PVP K25 into the SS solution, the habit of SS crystallized was modified and the crystal size was reduced to less than 10 microns. The inhibition mechanism for the selected polymers and surfactants were then further studied on …
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Cytochrome C biosensor for the determination of trace level arsenic and cyanide compounds
… blue, potassium cyanide and arsenic trioxide by inhibition mechanism. The sensitivity as calculated from cyclic voltammetry (CV) and square wave voltammetry (SWV), for each analyte in phosphate buffer (pH= 7) was found to be (1.087- 4.488 ×10-9 M) and the detection limits ranging from 0.0043- …
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Regulation of Mitochondrial Sirtuins Sirt3 and Sirt5 by Small Molecules
… in the FdL-1 complex involved in inhibition mechanism whereas the compound binding site in the ACS2 complex might imply the site for the activation mechanism of resveratrol on Sirt1. Resveratrol unrelated compounds including SRT1720, a potent synthetic Sirt1 activator, and Ex-527, …
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Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
… regulates apoptosis by inhibiting caspases. This inhibition mechanism is an escape from death used by some human cancers. Second mitochondria-derived activator of caspases (Smac), a mitochondria-released protein during apoptosis, binds to IAPs BIR domains with four amino acid residues (AVPI) and …
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Discovery and Design of NRF2 Modulators
… constitute the identification of a novel NRF2 inhibition mechanism, expanding the range of approaches to cancer treatment.
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Investigations of the inhibition mechanisms of human ribonucleotide reductase by gemcitabine-5'-diphosphate and saccharomyces cerevisiae ribonucleotide reductase by Sml1
… established that F2CDP is a sub-stoichiometric mechanism based inhibitor (0.5 equivalents F2CDP/[alpha]) of both the E. coli and the human RNRs in the presence of a reductant. Inactivation is caused by covalent labeling of RNR by the sugar of F2CDP (0.5 equivalents/[alpha]) and is accompanied by …
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The use of mineral oil as a trapping agent for volatiles produced by Ceratocystis moniliformis (Hedg.)
… limited due to toxicity, or perhaps a feedback inhibition mechanism. Seventeen volatile aroma compounds were tentatively identified by Gas Chromatography - Mass Spectrometry (GC- MS), and of these, the production of isoamyl acetate, B -myrcene, acetophenone, i1-octanol, and geraniol was studied …
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Nitroxides in Mechanistic Studies: Ageing of Gold Nanoparticles and Nitroxide Transformation in Acids
… oxygen concentration which is essential in the inhibition of polymerization. Oxygen-related broadening was deconvoluted from the EPR spectra of nitroxide radicals using an oximetry fitting method. By adopting this method, the inhibition mechanism and associated chemistry of nitroxides in …
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Regulation of mammalian IRE1α: Co-chaperones and their importance
… receptor. Despite significant research, the mechanism of coupling ER stress to IRE1 oligomerisation and activation has remained contested. There are two proposed mechanisms by which IRE1 may sense accumulating unfolded proteins. In the direct binding mechanism, unfolded proteins are able to …
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Studies on Corrosion, Fouling and Durability of Advanced Functional Nonwetting Surfaces
… surfaces (LIS). Second, the corrosion inhibition mechanism of SHS was systematically studied and modeled via electrochemical methods to elucidate the role of superhydrophobicity and other parameters on corrosion inhibition. The anti-corrosion properties of SHS and LIS were …
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Pulsed out of awareness: EEG alpha oscillations represent a pulsed inhibition of ongoing cortical processing
… Alpha oscillations represent a general pulsed inhibition in the brain. Chapter 1 contains a review of evidence that 8-12 Hz oscillations in the brain have a general inhibitory role in cognitive processing, with an emphasis on their role in visual processing. Chapter 2 presents additional …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
… of cardiovascular diseases. Hence, the inhibition of platelet aggregation is important for preventing the progression of arterial thrombosis. Rhubarb is a widely used traditional medicine and has been reported to elicit a number of biological effects including antiinflammatory and …
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FITSelect: An Invention to Select Microbial Strains Maximizing Product Formation from a Single Culture Without High-Throughput Screening
… screening. This novel system is called Feed-back Inhibition of Transcription for Growth Selection (FITSelect), and it uses a natural feedback inhibition mechanism in the L-arginine production pathway to select strains (transformed with a random genomic library) that can over-produce L-arginine in …
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Investigating the Therapeutic Potential of L-asparaginase in Myeloid Leukemia
… to the well-established protein synthesis inhibition mechanism. The findings from this study indicate that L-asparaginase elicits classical responses of amino acid deprivation in myeloid cells at both transcriptional and translational levels. In addition, pathway analysis using data from …
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Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… explains the autocatalytic, and subsequent auto-inhibition mechanism of Npro (i.e., why there is no trans activity), and furthermore provides insight into the interaction of Npro with IRF3 and its role in subversion of host immune response.
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INHIBITOR RESISTANCE MECHANISMS AND INHIBITOR DESIGN IN ¿¿-LACTAMASES
… of ¿¿-lactams, ¿¿-lactamases and ¿¿-lactamase inhibition are well studied and understood; there exist several knowledge gaps that can further our understanding of these mechanisms. By filling these gaps, we can gain a more detailed understanding of ¿¿-lactamase inhibition and facilitate the …
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Hemmung der Eisrekristallisation in wässrigen Lösungen durch Antigefrierglykopeptide
… the freezing point. But many aspects of the mechanism of action are still not understood, especially for antifreeze glycoproteins and glycopeptides (AFGP), which are present in some fish of the polar oceans. Therefore, within the present work several substances were investigated that inhibit …
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