Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3145 for “"inhibit"”.
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Investigating Novel Targets to Inhibit Cancer Cell Survival
Cancer remains the second leading cause of death in the United States and the world, despite years of research and the development of different treatments. One reason for this is cancer cells are able to survive through adaptation to their environment and aberrantly activated growth signaling. As …
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Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic Kras Function
… <em>in vivo</em>. Similarly, functionally inhibiting ORP5 and ORP8 by inhibiting PI4KIIIα-mediated synthesis of PI4P at the PM selectively inhibited the growth of KRAS-dependent cancer cells over normal cells <em>in vitro</em> and <em>in vivo</em>. Hence, inhibiting KRAS function through …
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Does Simulation Enhance or Inhibit the Development of Self-Knowledge?
… This thesis examined whether the WSE enhanced or inhibited the development of student self-knowledge. In the context of this thesis, self-knowledge can be considered as the aggregation of wisdom derived from internal and external stimuli that informs a substantial comprehension of one’s character, …
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Can Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms?
Intracranial saccular aneurysms are pathological dilations of cerebral blood vessels that can spontaneously rupture leading to significant morbidity and mortality. Our current understanding of saccular aneurysm pathogenesis involves a complex interplay of predisposing factors and inflammatory …
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Chemical Tools to Monitor and Inhibit poly(ADP -Ribosyl)ation
While several promising inhibitors of PARP have been developed, no crystal structure of the complementary enzyme poly(ADP-ribose)glycohydrolase (PARG) is available, and therefore it has been difficult to intelligently design compounds to inhibit this enzyme. To date, the known inhibitors of PARG …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… E. chaffeensis Notch stabilization of XIAP and inhibition of caspase activation. Based on the evidence collected during my research, I have concluded that a TRP120- TR Notch SLiM memetic motif directly binds Notch-1 at a region containing the LBD to activate Notch signaling. TRP120 Notch …
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Identification of Volatile Compounds Produced by Brevibacterium Linens that Inhibit Molds
… of compounds, several of these compounds are inhibitory to mold growth in environments other than cheese. The purpose of research presented in this thesis was to evaluate volatile compounds produced by B. linens for antimycotic activity. A method was developed to quantify inhibition of mold …
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Does alcohol inhibit posttraumatic stress symptomology in victims of sexual assault?
<p>The current study examines whether or not alcohol consumption during a sexual assault suppresses PTSD symptomology as well as the subjective impact of the assault. One hundred and fifty-one women participated in the study. The first hypothesis was that women in the alcohol condition would …
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Factors That Motivate and Inhibit Educators to Apply for the Principalship
… teachers. This study explores the motivating and inhibiting factors that educators consider when deciding to pursue the principalship.</p> <p>A web-based survey was administered to teachers in a large school district with urban, suburban, and rural schools and 196 responses were analyzed. The data …
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Targeting the Central Dogma to Inhibit Nodes of Convergence in Cancer
… resistance mechanisms, cancer treatments must inhibit multiple hallmarks of cancer, and therefore multiple oncogenic signaling programs. One possible way to achieve this is to target nodes of convergence of oncogenic signaling, in which multiple oncogenic pathways depend on one protein for …
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Identification of Epstein-Barr virus proteins that inhibit the DNA damage response
… tegument protein, BKRF4, was identified as an inhibitor of the DNA damage response. By studying the effect of BKRF4 on the steps of the DDR, it was shown that BKRF4 had no effect on the induction of γ-H2AX, but blocked the subsequent step at which histones H2A/H2AX become polyubiquitylated, …
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Black parent perceptions of factors which facilitate or inhibit participation in education
… to determine the factors that facilitate or inhibit Black parents' participation in the education of their children and what changes need to take place in order for them to be empowered in this area. Non-participating and participating parents of general education and special education …
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Nonclassical Mechanisms to Inhibit β-Hematin Crystallization Illuminate the Cooperative Action of Antimalarials
… develops a framework in which antimalarial inhibition may occur either at existing crystal surfaces or upstream through suppression of precursor populations and alteration of surface states. Application of this framework shows that tafenoquine is a weak inhibitor of classical step growth but …
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An Experiment Assessing the Potential for Compost-Amended Lawn Topsoil to Inhibit Storm Quickflow
Urbanisation creates immense challenges for the environment due to increasing impervious surface coverage enhancing quickflow discharge in the catchment. This makes increasing surface infiltration and soil water retention in urban areas a matter of high importance. Lawns, forming a substantial …
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Exploring factors that inhibit the Outlook Parent Support Group from achieving their stated goals
This study explored the factors that hindered the women of the Outlook Parent Support Group from achieving their stated goals. The literature review discusses the relationship between poverty and disability and its impact on the identity and occupations of carers of disabled children. Furthermore …
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Phytochemicals from Graviola fruit selectively inhibit breast cancer cells growth involving EGFR signaling pathway
… in our preliminary screening to selectively inhibit the growth of certain human BC cells (MDA-MB-468) but did not affect non-transformed breast epithelial MCF-10A cells. GFE treatment was very effective against the growth of MDA-MB-468 BC cells with an IC50 of 4.8 µg/ml. In vitro, effects of …
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AN INVESTIGATION OF THE MECHANISM BY WHICH ALUMINIUM AND OTHER POLYVALENT CATIONS INHIBIT ECCRINE SWEATING
The aim of this investigation was to elucidate the mechanism by which aluminium and other polyvalent cations reduce sweat output of human and rat eccrine sweat glands. It was shown that sweating in rat plantar eccrine sweat glands could be induced in the anaesthetized animal by systemic …
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Designing a Reactive Warhead to Bind and Inhibit Pseudomonas aeruginosa’s Periplasmic Protein, Inhibitor of Vertebrate Lysozyme
… aeruginosa</em> secretes a protein known as Inhibitor of Vertebrate Lysozyme (PaIVY) that binds to and inhibits C-type lysozyme, thus preventing the degradation of the bacterium. A reactive chemical warhead was synthesized from a rhenium(I) tricarbonyl derivative inorder to bind to and …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
… increase in [Ca2+]i, which was reversibly inhibited by the clinical EC50 of the i.v. anaesthetic thiopental. The EC50 for thiopental inhibition of nAChR induced [Ca2+]i transients was 28 µM, close to the estimated clinical EC50 of thiopental (25 µM). However, control experiments using Ca2+ …
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