Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"inherited cancer predisposition"”.
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Focused CRISPR-Cas9 screens investigating the DNA damage response
… cause a spectrum of disorders ranging from inherited cancer predisposition syndromes to developmental disorders. Genetic screens can be used to gain insights into the function of known DDR proteins, identify novel DDR components and highlight potential therapeutic opportunities. We …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
<p>Cancers of the spinal cord are uncommon neoplasms, the majority of which are glial cell tumors (ependymoma and astrocytoma) thought to arise from multipotent neuroglial progenitor (stem) cells (NPCs) within the spinal cord. Whereas many spinal ependymomas exhibit indolent behavior, the only …
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Omics Approaches to Uncover Germline and Somatic Variation Underlying Inherited Sarcomagenesis
… underlying sarcomagenesis, we leveraged two rare inherited cancer predisposition syndromes, Li-Fraumeni Syndrome (LFS), and LFS-like (LFSL), both with a high incidence of sarcomas. LFS is caused by mutations in the tumor suppressor gene <em>TP53 (p53)</em><em>, </em>but has variable and incomplete …
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Somatic mutagenesis in humans with deficient DNA repair
… in normal cells causes the development of cancer and is implicated as a potential mechanism in the physiological process of ageing. In recent years our ability to interrogate the genome of human cancers and the normal tissues from which they arise has expanded greatly. These studies have …
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Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
Lynch Syndrome (LS) confers an inherited cancer predisposition, particularly for colorectal cancer, due to germline mutations in one of the DNA mismatch repair (MMR) genes, such as MSH2. MMR is a DNA damage repair pathway involved in the removal of base mismatches and insertion/deletion loops, …