Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 266 for “"inhalation"”.
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Determination of inhalation injury
Respiratory tract injury caused by smoke inhalation is the most common early cause of death in thermal injury. Inhalation injury is most commonly assessed on the basis of clinical data, blood gas analysis, and bronchoscopy. Cardiopulmonary responses in the immediate post-injury phase of smoke …
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Controlled release in inhalation
… controlled release vectors into dry powders for inhalation was investigated. The first experimental section highlights the use of leucine in producing highly respirable spray dried powders, with in vitro respirable fractions (Fine particle fraction, FPF: F < 5µm) exceeding 80% of the total dose. …
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Manipulation of carrier particles for inhalation
The work described in this thesis was performed to investigate the effect of altering the conditions of recrystallisation for selected sugars and sugar derivatives (lactose, trehalose dihydrate and trehalose octa-acetate (TOAc» in order to assess the physical effect on the material surface. In …
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Clarithromycin nanocrystals for high-dose inhalation
Pneumonia remains a major global cause of morbidity and mortality, especially where access to care is limited. Standard oral / i.v. antibiotics often require high systemic doses to reach effective lung levels, increasing adverse effects, lowering adherence and fostering resistance. This work …
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Inhalation exposure system for diesel exhaust particulates
… research were twofold. First, a Hazelton 2000 Inhalation Chamber was modified to minimize the amount of diesel exhaust particulate (DEP) needed for animal inhalation exposures. Second, instrumentation was evaluated for aerosolizing DEP, monitoring the mass concentration and size distribution, …
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Histamine Metabolism During Asthma Induced By Inhalation Challenge
… according to their occurrence during and after inhalation of the highest MCH increment, these maxima were in each instance significantly higher (P 50 cu). This suggests that bronchial sensitivity to this cholinergic agent may be unrelated to the magnitude of HM release from lung. In only 1 …
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Engineering of Inhalation Aerosols Combining Theophylline and Budesonide
… route for respiratory disease treatment is by inhalation, such as dry powder inhalers (DPI) being the delivery systems of first choice. As shown recently, there is an advantageous effect if the drugs are given simultaneously which is caused by a synergistic effect at the same target cell in the …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… using L-leucine (L-leu) to be delivered via inhalation was developed. Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL, NPs with either anionic or cationic surface charge of optimum size (~200-250 nm) to be effectively taken up by the lung dendritic cells (DCs) were successfully …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… suitable for local delivery. Additionally, oral inhalation (OI) has long been accepted as the preferred mode of administration of therapeutics to the lungs. To address these discussed challenges, we used a strategy — polymeric nanocarriers (PNCs) to achieve the spatial and temporal drug release …
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Evaluation Of Presynaptic Dopamine Dynamics After: Toluene Inhalation Or Trkb Receptor Activation
… tissue content analysis to examine how toluene inhalation alters the striatal DA system. Overall, both behavior and neurochemical data confirmed that toluene inhalation alters stimulated DA release in striatum. Mechanistically, the neurochemical data indicated that acute toluene inhalation …
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Acute Neuropathological Alterations after Smoke Inhalation Injury, with and without Skin Burn
More than 23,000 smoke inhalation injuries are reported in the United States each year. While the pathophysiology of smoke inhalation-induced lung injury is well studied, little is known about the acute effects of smoke inhalation on the central nervous system (CNS). Tragic events, such as those of …
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Multisystem Effects of Mold Inhalation: A Convergence on the Central Nervous System
… affects the CNS. Here, I show that subchronic inhalation of a common indoor mold, Aspergillus versicolor, causes neuroinflammatory gene transcription in five out of five brain regions tested, at both 1 and 2 days post inhalation. How peripheral inflammation from mold inhalation causes …
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Relative bioavailability of terbutaline to the lungs following inhalation using different methods.
… lung and systemic bioavailability following inhalation and to measure the in-vitro characteristics of the emitted dose by these inhalation methods. Two new robust, accurate and sensitive high performance liquid chromatography methods for the determination of terbutaline in aqueous and urine …
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T2 Mycotoxicosis in Swine Following Topical Application, Intravascular Administration and Inhalation Exposure
… (15 mg/kg), intravascular (0.6 to 5.4 mg/kg) or inhalation (8 or 9 mg/kg; 20 to 30 percent retention) exposure.
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Comparing the efficacy of fiber reinforced actuators to replicate inhalation vs. exhalation
Fluid Powered Elastomeric Actuators are a class of soft robotic actuators of particular interest for biomimetic designs because researchers can replicate certain motions by tailoring the mechanical properties of the actuator through the use of different fibers and materials. [1] Hu et al. showed …
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PULMONARY DELIVERY OF PNEUMOCCOCAL VACCINE USING NANOCOMPOSITE MICROPARTICLE CARRIERS VIA DRY POWDER INHALATION
… micro#particles (NCMPs) dry powder for inhalation. Parameters for the preparation of protein-loaded polyester poly (Glycerol Adipate-co-ω-Pentadecalactone), (PGA-co-PDL) NCMPs were optimised using Taguchi design and BSA as a model protein, by the double emulsion solvent evaporation …
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