Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"infralimbic"”.
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FEAR EXTINCTION AND INFRALIMBIC CORTEX IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
… to altered neurocircuitry, particularly in the infralimbic cortex (IL), a key region in fear extinction. Despite extensive evidence of impaired fear extinction in mild TBI patients and animal models, the specific mechanisms underlying this deficit remain poorly understood. This study aimed to …
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The Role of the Infralimbic-Basal Forebrain Pathway in Fear Extinction
… Post Traumatic Stress Disorder. Study of how the Infralimbic cortex (IL), a subregion of the mPFC, directly communicates with the Basolateral Amygdala (IL-BLA), has thus far failed to uncover the circuit mechanisms that lead to mPFC-mediated amygdala suppression of firing and diminished fear …
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Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
… of extrasynaptic GABAA receptors located in the infralimbic cortex (ILC) in the binge-like alcohol intake of male C57BL/6J (B6) mice. The ILC is of interest due to its demonstrated involvement in stress reactivity and alcohol exposure has been shown to interfere with extinction learning; …
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Adenosine monophosphate-activated protein kinase regulates reward regions of the brain during cocaine sensitization
… of the prefrontal cortex, the prelimbic and infralimbic cortices, differentially regulate reward signaling. For example, the prelimbic cortex is known to be necessary for establishing cocaine sensitization while the infralimbic cortex is not. AMPK’s role in cocaine sensitization remains …
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… shown to predict lower grey matter volume in the infralimbic cortex and ventral striatum. Functionally, compulsivity and stickiness were predicted by decreased connectivity between the prelimbic cortex and the anterior cingulate cortex with the posterior dorsomedial striatum. In summary, this …
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Adversity in early adolescence alters female rats' anxiety-related behaviours and serotonergic innervation profiles in adulthood
… axon density were found in the infralimbic (IL) subregion of the mPFC, but not in the cingulate or prelimbic (PL) subregions. IPS in early adolescence did not affect serotonergic innervation profiles in any sub-fields of the ventral hippocampus. The findings confirm and extend on …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… of inhibitory neuronal populations in the infralimbic prefrontal cortex (IL-PFC) and the CA1 region of the hippocampus. No overall group differences were observed across all five treatment groups in the ILPFC and CA1.</p>
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The connectivity of the mammalian prefrontal cortex
… -100 nl) into subdivisions of PFC (prelimbic, infralimbic, medial-orbital, ventral-orbital, ventrolateral-orbital, lateral-orbital and dorsolateral-orbital) and their projections studied. Tracer studies identified clear evidence of significantly ordered projections from PFC to temporal and …
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The Effect of Typical and Atypical Antipsychotics on the MK-801 Induced Deficit in Behavioural Inhibition
… immunohistochemical labeling of pERK1/2 in the infralimbic cortex (IL) was examined after extinction lever pressing to determine the importance of the IL in mediating these behavioral changes. A dose-response curve revealed an extinction deficit following administration of 0.1 mg/kg of MK-801. …
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Structural and Molecular Correlates of Individual Differences in Anxiety Behavior and the Stress Response
… levels in the PTSD-like group was lower in the Infralimbic mPFC. These results emphasize the importance of individual differences in behavior, and show that there are significant structural and molecular differences between adult male rats. They also illustrate the need for experiments that …
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Forebrain Noradrenergic Alterations and Anxiety After Myocardial Infarction
… of the lateral nucleus of the amygdala and the infralimbic (IL) portion of the medial prefrontal cortex (mPFC) was increased in MI rats compared to sham-operated rats. Electrical stimulation of the locus coeruleus (LC), in a pattern mimicking a mild stressor, decreased metabolic activity in the …
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Neurochemical and Neuroanatomical Basis Of Reversal Learning In The Rat
… dissociable effects. Inactivation of the infralimbic cortex led to a significant general improvement in reversal learning regardless of phase, while inactivation of the medial orbitofrontal cortex led specifically to a significant reduction in the number of errors during perseveration. By …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… layer 2/3. Pyramidal neurons in layer 2/3 of the infralimbic (IL) sub-region of the mPFC, displayed decreased dendritic arborization, concomitant with reduced intrinsic excitability. Conversely, prelimbic (PL) layer 2/3 neurons displayed normal dendritic arborization, but increased intrinsic …
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Neural Plasticity in the Amygdala Across the Development of an Incentive Cocaine Seeking Habit
… cortex, the prelimbic cortex, and the infralimbic cortex. Using the immediate early gene cFos as a marker of cellular activity, I performed RNAscope on brain sections encompassing the PFC to explore the behavioural relevance of specific PFC-BLA projections. Taken together the results …
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Investigating reinforcement learning processes in depression and substance use disorder: translational, computational and neuroimaging approaches.
… the amygdala to the anterior cingulate cortex, infralimbic cortex and insular cortex compared to males. The subsequent chapter uses a computational approach to investigate latent vulnerability variables in cocaine addiction. A longitudinal dataset acquired in rats was analysed, which involved …
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Analisi dell’espressione della fosfoERK quale strumento di indagine per la caratterizzazione della sensibilità alle sostanze d’abuso in linee di ratti geneticamente selezionati
… ERK phosphorylation in Acb, prelimbic (PrL) and infralimbic (IL) prefrontal cortex (PFCx) and nuclei of the extended amygdala (BSTL, CeA and BLA). The results of these experiments demonstrate 1) that morphine significantly decreased Acb pERK expression, as determined by counting the number of …