Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"influenza virus infection"”.
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Intrinsic genetic resistance of lymphocytes to influenza virus infection
… with protection of lymphocytes against infection by influenza virus. There was absence of viral transcription in the lymphocytes of HLA-A homozygous subjects, although all monocytes were infected.\r\nMy specific aim was to determine if such resistance was evident in HLA-B homozygous …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… airway epithelium represents the primary site of infection for many respiratory viruses, including influenza A virus (IAV). To safeguard this tissue and maintain the functionality of the lung, humans possess a two-layer, extracellular, mucus barrier composed predominantly of individual proteins …
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Investigating sphingolipid behavior and function using metabolic labeling
… roles in membrane organization and that virus infection requires intense membrane reorganization, the involvement of acid sphingomyelinase or sphingomyelin phosphodiesterase 1 (SMPD1), a sphingolipid metabolizing enzyme, in influenza virus infection and particularly its entry was …
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Characterization of The Roles of Carma3 and Bcl10 In Virus-Triggered Rig-I/Mavs Signaling Pathway
<p>After RNA virus infection, the innate immunity utilizes RIG-I family of receptors in the cytoplasm to initiate the production of type-I IFNs and proinflammatory cytokines by mitochondrial protein MAVS, which forms a prion-like structure to recruit TBK1and IKK complex to activate IRF3 and NF-κB, …
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Systems Immunology Approaches for Precision Medicine
… interactions during Clostridium difficile infection and the use of this model for the development of the hypothesis that host-antimicrobial peptide production may correlate with increased disease severity and promote increased recurrence. Secondly, it provides insight into the necessity of …
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Improving Inpatient Influenza Compliance Rates with a Standing Orders Program
<p>Influenza vaccinations are recommended yearly as part of a primary care performance measure to prevent and control seasonal influenza. Rates of influenza are steadily increasing and can lead to severe negative impacts and even fatalities with patients. According to the Center for Disease Control …
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Antigen-specific memory T cell distribution in non-lymphoid tissue
… to intracellular pathogens, particularly viruses, and tumor antigens. In the case of influenza, activated T cells migrate from the mediastinal (draining) lymph nodes to the lung where they perform their cytolytic function. After pathogen clearance, memory CD8+ T cells are generated, giving …
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Effects of Exercise on Immune Function in Young, Adult, and Aged Mice: Increased Survival and a Decrease in Inflammation
… response significantly increases survival during influenza virus (A/PR/8/34) infection in mice. We hypothesized that this brief duration of exercise resulted in a decreased level of lung histopathology while altering the immune response from a Th1 (inflammatory) to a Th2 (Anti-inflammatory) …
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Attenuation of Interferon Responses in the Obese Host and Ramifications for Influenza Virus Evolution
… communicable diseases. Following the 2009 H1N1 influenza A virus pandemic, obesity was identified as a risk factor for increased disease severity and mortality in infected individuals. Obesity causes a chronic state of meta-inflammation with systemic implications for immunity, including delayed …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… was unable to induce Treg cell activity during influenza virus infection. Conversely, when the same Ag was derived from an influenza virus, it drove Treg cells to proliferate and acquire a T-bet+CXCR3+ phenotype, and to suppress the accumulation of CD4+Foxp3- and CD8+ effector T cells in the …
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The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein
Influenza B virus is a major human pathogen causing highly contagious respiratory disease. It accounts for approximately ~30% of influenza virus infection per year. The effector domain of the NS1 protein of influenza B virus (NS1B protein), encompassing the carboxy terminal two thirds of the …
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Exploring the roles of key lipids in the influenza virus lifecycle
The influenza virus is a common respiratory pathogen with the capacity to cause global pandemics affecting millions of people, contributing substantially to overall mortality and morbidity. Thus, considerable research focuses on the prevention and treatment of influenza virus infection. Despite the …
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Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis
Influenza A virus (IAV) causes annual seasonal epidemics and occasional pandemics resulting in significant levels of mortality and socio-economic costs worldwide. PB1-F2 is a small non-structural protein encoded by an alternate +1 open reading frame in the PB1 gene. PB1-F2 is considered to play …
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The Molecular Basis of Fitness and Transmissibility of Neuraminidase Inhibitor Resistant Influenza A Viruses
… are among the first line of defense against influenza virus infection. Development of resistance to NA inhibitors is a huge drawback for limited options for the control of influenza. During the first decade of NA inhibitor use, the detection rates of resistance to both NA inhibitors had …
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Viral- and host-targeted interventions to improve influenza disease outcomes
… work by scientists and public health officials, influenza viruses continue to cause widespread morbidity and mortality. Each year it is estimated that these pathogens infect up to 20% of the global population, leading to nearly a million deaths. In considering this, it is clear that additional …