Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"influenza evolution"”.
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Network and Algebraic Topology of Influenza Evolution
Evolution is a force that has molded human existence since its divergence from chimpanzees about 5.4 million years ago. In that same amount of time, an influenza virus, which replicates every six hours, would have undergone an equivalent number of generations over only a hundred years. The fast …
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Integrative approaches to decipher influenza evolution, antibody responses, and AI-driven specificity prediction
… of viral pathogens, such as SARS-CoV-2 and influenza Viruses, highlights the urgent need to understand immune responses and viral evolution to guide therapeutic and vaccine development. This dissertation integrates high-throughput experimental techniques and artificial intelligence (AI) to …
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Defining the Influence of Host Cell Proteostasis Networks and Temperature on Influenza Evolution
… random acquisition of mutations drive this high evolutionary rate, but constant pressure from the host also contributes. As minimalistic pathogens, viruses rely on host machineries to synthesize, fold, and degrade their proteins. These proteostasis machineries can influence the accessible …
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Zeolites Structure, Influenza Evolution and Vaccine Effectiveness, with Prediction of Emerging Flu Strain Clusters
… targets. The second part concerns about the evolution of Influenza viruses and discusses a way to prediction vaccine effectiveness. Influenza A is a serious disease that causes significant morbidity and mortality, and vaccines against the seasonal influenza disease are of variable …
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Characterization of influenza A virus evolution in laboratory hosts
Surveillance of influenza A virus (IAV) is conducted for many different hosts including humans, swine, poultry, and wild birds. The surveillance samples are screened by various methods, but ultimately the isolates that are positive for IAV are propagated in a laboratory host prior to genome …
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Virologic Factors Contributing to the Genetic Diversification of Influenza Viruses Circulating in North American Swine
… to determine mechanisms of reassortment of swine influenza viruses and determine if certain reassortant gene combinations can drive evolution and host adaptation in the context of the triple reassortant internal gene (TRIG) cassette. The TRIG contains a unique combination of a human polymerase …
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Predicting the Antigenic Evolution of Influenza Viruses with Application to Vaccination Strategy
Seasonal influenza viruses cause substantial worldwide mortality and morbidity every year. The evolution of these viruses comprise unique systems for studying natural evolutionary processes in real-time. Host immune systems recognise pathogens based on binding affinities between host antibodies and …