Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 143 for “"influenza A"”.
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Influenza A Virus Induced Programmed Cell Death
Influenza A viruses (IAV) are negative sense RNA viruses that naturally infect a wide variety of animals. Different subtypes of the virus infect waterfowl, poultry, pigs, horses, ferrets, bats, dogs, cats and humans, causing zoonotic outbreaks and pandemics. In humans, IAV strains cause seasonal …
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Universal room-temperature stable influenza A nanovaccine
Seasonal influenza A virus (IAV) is annually responsible for an estimated one billion infections, nine million hospitalizations, and 300,000 – 600,000 deaths annually. Considering the potential influenza pandemic threat, the development of a universal IAV vaccine is paramount to global public …
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Influenza : a study of contemporary medical politics
… prevention and control of seasonal and pandemic influenza has grown to be one of the largest and most visible public health policies. This dissertation considers contemporary influenza policy as a case study in what I call medical politics, in which a disease that for most people is rather …
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Pandemic Potential of Reassortant Swine Influenza A Viruses
<p>Influenza A viruses are capable of causing disease in several species, including birds, humans and swine. Host specificity of the viruses is not absolute, and is influenced by a range of factors. Swine play a pivotal role in the interspecies transmission of influenza A viruses, as they are …
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INTERSPECIES TRANSMISSION AND HOST RESTRICTION OF INFLUENZA A VIRUSES
Type A influenza viruses can infect both mammals including humans, pigs, horses, cats, dogs, ferrets, and sea mammals as well as domestic and wild birds. Although influenza A viruses shows host range restrictions, interspecies transmission have been documented at many occasions. Swine have been …
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Decoding aberrant RNA Synthesis by the Influenza A Virus
Influenza A viruses (IAV) are negative-strand segmented RNA viruses and are responsible for causing severe respiratory diseases and fatalities in humans. IAV encodes an RNA-dependent RNA polymerase (FluPolA), which is responsible for transcribing and replicating each segment of the viral genome. In …
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Glycan receptor binding determinants of Influenza A virus hemagglutinin
… the factors involved in the human adaptation of influenza A viruses is critical for various aspects of influenza preparedness, including the development of appropriate surveillance measures, preventive strategies and effective treatments. A key step in influenza human adaptation is the …
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Characterization of influenza A virus evolution in laboratory hosts
Surveillance of influenza A virus (IAV) is conducted for many different hosts including humans, swine, poultry, and wild birds. The surveillance samples are screened by various methods, but ultimately the isolates that are positive for IAV are propagated in a laboratory host prior to genome …
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Airborne Transmission of Influenza a Virus in Indoor Environments
… know remarkably little about the dynamics of the influenza virus in the environment during transmission between hosts. There is still controversy over the relative importance of various transmission routes, and the seasonality of influenza remains unexplained. This work focuses on developing new …
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Host Modulators of the Death Response to Influenza A Infection
Influenza A virus infects 5-20% of the population annually, resulting in ~35,000 deaths and significant morbidity. Current treatments include vaccines and drugs that target viral proteins. However, both of these approaches have limitations, as vaccines require yearly development and the rapid …
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Interferons in Influenza A Virus and Streptococcus Pneumoniae Co-Pathogenesis
Secondary pneumococcal pneumonia postinfluenza significantly increases the disease burden associated with influenza A virus (IAV) infection. IAV induced interferons (IFN) play a crucial role in antiviral immunity. However, recent reports have indicated that influenza-induced IFN-I and IFN- γ …
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Pam2ODN-Induced Epithelial Resistance Against Influenza A Requires STAT3 Activation
… for Pam2ODN-induced protection against the influenza A virus (IAV).</p> <p> In our in-vitro model, human bronchial epithelial cells (HBEC3-kt) were treated with STAT3 inhibitor C188-9 prior to receiving Pam2ODN treatment, and then were infected with IAV. We performed quantitative-PCR probing …
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Investigating the role of Sialoadhesin in Influenza A virus infection
… to address Sn’s regulation of immunity towards influenza A virus (IAV), a respiratory virus devoid of terminal Sia due to its surface viral neuraminidase. Additionally, infection by IAV triggers a well-defined innate and adaptive immune response that can be modulated by Sn through cell-cell …
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Influenza A Virus PB1-F2 Protein: its Role in Pathogenesis
Influenza A virus (IAV) causes annual seasonal epidemics and occasional pandemics resulting in significant levels of mortality and socio-economic costs worldwide. PB1-F2 is a small non-structural protein encoded by an alternate +1 open reading frame in the PB1 gene. PB1-F2 is considered to play …
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Mechanistic Studies of Small Molecule Entry Inhibitors of Influenza A Viruses
Influenza A viruses (IAVs) are the most problematic among the four genera of influenza viruses owing to their high abilities to genetically adapt to various animal species. Infections caused by IAVs, termed “flu”, lead to seasonal epidemics and have thus far caused 4 large-scale pandemics in the …
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Molecular biology of segment 8 of the influenza A virus genome
The single-stranded RNA genome of influenza A virus is divided into 8 segments, each of which encodes at least one polypeptide product. This work presents investigations into two aspects of the biology of the smallest (8th) segment: 1) a possible new gene product and 2) interactions of the viral …
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The Influenza A Virus NS1 Protein and Vriral mRNA Nuclear Export
Influenza A virus (IAV) replication and transcription occur in the host cell nucleus; a feature which means both the viral genome (vRNA) and mRNA must be exported from the nucleus to the cytoplasm. The mechanism by which vRNA nuclear export is achieved has been well characterised, but how viral …
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Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin
The critical first step in the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and …
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Predicting Mutational Pathways of Influenza A H1N1 Virus using Q-learning
Influenza is a seasonal viral disease affecting over 1 billion people annually around the globe, as reported by the World Health Organization (WHO). The influenza virus has been around for decades causing multiple pandemics and encouraging researchers to perform extensive analysis of its …
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Die Rolle des Transkriptionsfaktors NF-KappaB in Influenza-A-Virus infizierten Zellen
… Infektionen, einschließlich der Infektion durch Influenza-A-Viren (Hiscott J. et al., 2001). Da die Expression vieler proinflammatorischer und antiviraler Zytokine, wie IFNb oder TNF-a durch NF-kB kontrolliert wird, hat sich ein Konzept entwickelt, welches besagt, dass NF-kB und sein …
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