Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"inflammatory skin disease"”.
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Pathological meprin alpha expression as a driver of inflammatory skin disease
The skin is the largest organ and the body’s outermost barrier, with the epidermis as its outermost layer. The epidermis consists of distinct layers composed of keratinocytes at different stages of terminal differentiation. This process is orchestrated by a network of epidermal proteases, which …
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Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the disease has increased by two to three-fold in industrialized countries, with higher incidences in …
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ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS
Atopic dermatitis (AD) is a common inflammatory skin disease, which is characterized by skin barrier defect and immune dysregulation. In this study, we investigated the role of microRNA in AD pathogenesis. We found miR-335 to be highly expressed in the differentiating layers of normal epidermis but …
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Role of Lifestyle Modifications in the Management of Hidradenitis Suppurativa in Adults: A Systematic Review [paper]
… Hidradenitis suppurativa is a chronic inflammatory skin disease characterized by recurrent abscesses. The exact cause is unknown, but there is an association with obesity, diabetes, and pro-inflammatory habits like smoking. The purpose of this systematic review is to appraise existing …
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HIDRADENITIS SUPPURATIVA WITH 20 OR MORE DRAINING TUNNELS: A NATION-WIDE RETROSPECTIVE STUDY.
… Suppurativa (HS) is a chronic-relapsing, inflammatory skin disease of the terminal hair follicle, manifesting with nodules, abscesses and draining tunnels (dT) on intertriginous areas. Treatment options are limited and patients with elevated draining tunnels (dT) counts have been …
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Determinants of systemic treatment response in atopic dermatitis
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intense pruritus and recurrent eczema. Its heterogeneous pathophysiology involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted …
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Expression and function of small RNAs in normal and psoriatic skin
Psoriasis is a chronic, inflammatory skin disease characterized by hyperproliferation and altered differentiation of keratinocytes, and infiltration of activated immune cells in the epidermis. Array based genome-wide expression studies by our lab and others have revealed over 1,300 alterations in …
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Ex-vivo Untersuchungen zur Arzneimittelwirkung topischer Tacrolimus (FK-506) Anwendung auf epidermale dendritische Zellen in läsionaler Haut bei Patienten mit atopischem Ekzem
… BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which antigen-presenting epidermal dendritic cells (DCs), ie, Langerhans cells and the so-called inflammatory dendritic epidermal cells (IDECs) expressing the high-affinity receptor for IgE (FcepsilonRI) may play a …
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Mapping the microbiota in hidradenitis suppurativa
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the formation of nodules, abscesses, and fistula at intertriginous sites. Pain, pruritus, malodour, and suppuration have a significant impact on quality of life for HS patients. The skin-gut axis is an area of …
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A systematic review of treatments for atopic dermatitis
Atopic dermatitis is a very common inflammatory skin disease, particularly in children. A systematic review of randomised controlled trials of treatments for atopic dermatitis (AD) was carried out to assess how many trials exist, what they cover, what they do not cover, the research gaps, provide a …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with complex environmental and genetic predisposition factors. Primary skin barrier dysfunction and aberrant T helper 2 (TH2) responses to common allergens, together with increased serum IgE antibodies, characterise the disease. …
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Mechanisms of atopic dermatitis and allergy development in African (AmaXhosa) children between 12-36 months of age
… dermatitis is a highly complex multifactorial inflammatory skin disease that disproportionately affects children and has increased rapidly during recent years in South Africa. Current data suggest that the changing diversity of environmental exposures, diet, and lifestyle factors across African …
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Staphylococci of the Skin: Consequences for Host Health
The skin is the body’s largest barrier organ, and as such hosts roughly one million bacteria per square centimeter over its 1.8m2 surface area. As a barrier organ, the skin not only provides a physical layer of defense against these microbes but an immunological one as well. Immune cells present in …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… drives a desire to scratch. It can induce severe skin damage and critically affect psychological wellbeing (e.g., sleep-deprivation, body-image insecurity). To investigate the burden of itch, a survey was conducted with ~2500 women within the general German population, where more than one third …
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Improving the skin barrier function in atopic dermatitis
… dermatitis, AD (synonym eczema) is a chronic inflammatory skin disease. It affects between 10 to 20% of children and 1 to 3% of adults worldwide. It is an important cause of morbidity and is estimated to cost £465 million per annum to the UK. AD is part of a family of Th-2 driven diseases and …
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Genomic investigation into the evolution of <i>Staphylococcus aureus</i> and the micro-epidemiology of <i>Staphylococcus aureus </i>in atopic eczema
… natural habitats is as a commensal on the human skin. The overarching aim of this project was to understand the genetic basis of this organism’s adaptation in the face of human intervention and influencing its survival in the human host, specifically during colonisation of the skin.<br/><br/>From …
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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa
<p>Hidradenitis suppurativa (HS) is an inflammatory skin disease manifesting in painful nodules and abscesses, and malodorous draining tunnels in more advanced disease. Effective treatment options remain limited, with Tumor Necrosis Factor inhibitor adalimumab remaining the only approved biologic …
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Intrinsic alterations of the skin barrier function promote the pathogenesis of atopic dermatitis in dogs
Canine atopic dermatitis (cAD) is a chronic inflammatory skin disease affecting up to 10% of the canine population, it is the second most common allergic disease in dogs. Canine AD has many similarities to human AD and for this reason the dog has been suggested to be a good animal model to study AD …
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Development of a Multispectral VIS-SWIR Imaging Modality for Cutaneous Water Assessment
<p>Inflammatory skin diseases are estimated to impact 20% of the global population and are the fourth leading cause of nonfatal disability worldwide. Diagnosis and management are predominantly based on clinician visual assessment of disease related changes in skin morphology. The qualitative nature …
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Microbial interactions with epithelial surfaces.
… pathogen that causes a multitude of human diseases. Many of these diseases are associated with the production of staphylococcal exotoxins. Superantigens are a family of staphylococcal exotoxins associated with many of these illnesses. Superantigens are defined by their abilities to induce …