Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 79 for “"inflammatory pathways"”.
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Investigating Inflammatory Pathways in Alcohol-Associated Liver Disease
… pathogenic mechanisms involve many biochemical pathways and processes. Some of the key factors include iron overload, reactive oxygen species (ROS) production and mitochondrial dysregulation. This project aimed to investigate the role of alcohol and iron in inducing liver damage and toxicity. …
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Identifying mutational landscape and inflammatory pathways associated with lung squamous premalignant lesion progression
… correlations with important immuno-regulatory pathways, as well as their impact in the progression or regression of PMLs. The Lung Pre-Cancer Genome Atlas (PCGA) has begun to achieve the aforementioned goals of understanding the early molecular events in the process of lung squamous …
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Host Inflammatory Pathways in Malaria Infection: Potential Therapeutic Targets and Biomarkers of Disease Severity
… The goals of this work were: (1) to characterize inflammatory responses to malaria by defining their relationship to phagocytosis and identifying novel molecular mediators, and (2) to evaluate the utility of biomarkers of inflammation and other host responses for predicting outcome in severe …
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Examining effects of milk ferment components on endothelial cell signaling in pro-inflammatory pathways
Atherosclerosis is a complex, multifactorial, inflammatory disease involving cholesterol, endothelial cells, smooth muscle cells, macrophages and platelets. Atherosclerosis, and the associated cardiovascular diseases it contributes to, has been a growing health care and economic concern over the …
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Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier
… verified by treating BBB endothelial cells with inflammatory cytokines like TNF-α, which inhibited insulin signaling and increase the expression of vascular cell adhesion molecule-1 (VCAM-1), a marker for endothelial inflammation. Alternatively, exposure to soybean oil nanoemulsion (SNEs) like …
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The role of seminal plasma in the regulation of inflammation and inflammatory pathways in the cervix: potential for cervical cancer progression and HIV transmission in South African women
Cervical cancer is a chronic inflammatory disease of multifactorial etiology accounting for an annual estimated 266,000 deaths worldwide and usually present in sexually active women. In sub-Saharan Africa, cervical cancer is the most common cancer among women and the leading cause of cancer related …
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Novologue Therapy Improves Mitochondrial Bioenergetics and Modulates Transcriptome Changes in Diabetic Sensory Neurons
… modulated transcription of genes involved in inflammatory pathways independently of Hsp70. In contrast, the effects of KU-596 on genes involved in the production of reactive oxygen species (ROS) are Hsp70-dependent. Our data indicate that modulation of molecular chaperones offers an effective …
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Exploring the Role of PANNEXIN1A in an Acute Experimental Model of Parkinson's Disease
… larvae caused metabolic stress, regulated inflammatory pathways, and reduced ATP production. Local field potentials recorded from three regions of the ascending visual pathway showed complex changes in the beta- and gamma-band power and in the coherence between these regions. MPTP treatment …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. This network is underpinned by interaction and coordination of two …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… series of biochemical events that activate inflammatory pathways and negatively impact PR function. In this study, we uncovered a new regulatory pathway whereby miRNAs serve as hormonally-modulated and conserved mediators of contractile gene regulation in the pregnant uterus from mouse to …
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Pharmacological profiling of novel melanocortin peptides targeting the hMC1, hMC3 and hMC5 receptors in 2-D and 3-D models of activated chondrocytes
… The pathology of OA is mediated by a complex inflammatory response predominantly driven by elevated levels of interleukin-1beta (IL-1b), in addition to tumour necrosis factor-alpha (TNF-a). Endotoxins such as lipopolysaccharide (LPS), or Nitric Oxide donors such as …
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Anti-inflammatory and chondroprotective role of tart cherry polyphenols in SW1353 human chondrocytes
… effect on total protein expression of the pro-inflammatory transcription factor, necrosis factor kappa B (NF-κB), or the matrix degrading enzyme, matrix metalloproteinase-3 (MMP-3). In conclusion, these findings suggest that TCP promote cartilage health by modulating pro-inflammatory pathways …
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Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif
… the RxDL motif to inhibit the activation of host inflammatory pathways. MCV mutants with mutated RxDL motifs were assessed for the ability to inhibit TBK1- and MAVS- induced activation of interferon-β. Surprisingly, the RxDL mutants retained the ability to inhibit IFN-β activation as assessed by …
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Biophysical Investigation into the Protein Dynamics Governing the Allosteric Regulation of Plant and Animal 15-Lipoxygenases
… are involved in both homeostasis and pro-inflammatory pathways. In order to selectively target the activity of these enzymes, research has turned to allosteric regulation, which is the focus of this Thesis. Previously, the allosteric regulation of a model plant 15-LOX, soybean …
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Type 2 Diabetes Impairs Interleukin-4 Function in Macrophages and Amplifies the Brain-Based Neuroimmune Response
… by activated macrophages that secrete proinflammatory cytokines in response to immune insult. These messenger molecules communicate immune status to the brain to elicit important metabolic and behavioral changes that act to minimize transmission of infection and maximize the host's …
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The Metabolic Effects of Low Grade Inflammation on Postprandial Metabolism Following a High Fat Meal
… meal to be impaired in mice pre-injected with an inflammatory agonist. To this end, C57BL/6J mice were injected with saline or lipopolysaccharide (LPS, 1μg/kgbw) following an overnight fast and gavaged 2hr post-injection with water or a HF meal in liquid form (5kcal; 21.4%SF, 40.8%UF, 27.1%CHO, …
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Molecular mechanisms of radiation-induced brain injury
… the effects of whole brain irradiation on pro-inflammatory pathways in the brain were examined. Results demonstrated that brain irradiation induces regionally specific alterations in pro-inflammatory environments through activation of pro-inflammatory transcription factors (e.g., activator …
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Role of infection and inflammation in a mouse model of preterm labour
… evidence highlights that term labour is an inflammatory event associated with increased production of pro-‐inflammatory mediators and leukocyte influx into the intrauterine tissues. Preterm labour (PTL), defined as labour before 37 weeks gestation, is a major clinical problem, and preterm …
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