Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"inflammatory pain"”.
-
MRGX1-TRPAI in inflammatory pain signalling
Painful stimuli are detected at the peripheral terminals of specialised primary sensory neurons known as nociceptors. Nociceptors detect noxious (painful) stimuli to evoke pain sensation via the activation of Transient Receptor Potential Ankyrin 1 (TRPA1). TRPA1 activity can be modulated by …
-
Spinal cord plasticity in peripheral inflammatory pain
Inflammatory pain is a debilitating condition that can occur following tissue injury or inflammation and results in touch evoked pain (allodynia), exaggerated pain (hyperalgesia) and spontaneous pain, yet the neural plasticity underlying these symptoms is not fully understood. However, it is known …
-
Targeting the Endocannabinoid System to Reduce Inflammatory Pain
… and FAAH inhibitors reliably produce anti-inflammatory and anti-hyperalgesic effects in the carrageenan test and other inflammatory pain models, much less is known about the consequences of inhibiting MAGL in these assays. Here, we tested whether the selective MAGL inhibitor JZL184 would …
-
TIMP-1 as a Modulator of Inflammatory Pain
The prevalence and financial impact of chronic pain is substantial, and the presence of unresolved inflammation predicts its development. However, the mechanisms underlying unresolved inflammation are not well understood. Therefore, investigation of pathways involved in resolution of inflammatory …
-
Central and peripheral mechanisms of pain modulationthe role of the Locus coeruleus and pupillary dynamics in neuropathic and inflammatory pain
Pain is a complex sensory and emotional experience that results from the interaction between peripheral nociceptive input and central processing in the nervous system. Despite its clinical relevance and social impact, the management of pain, particularly chronic pain remains a significant …
-
A Two-Pronged Approach to Stemming the Opioid Epidemic: Preclinical Strategies for Substance Use Disorder Medications Development and Liquid Biopsy Detection of Inflammatory Pain
… friends and family members for recreational use. Pain clinicians are in desperate need of a reliable methodology to quantify pain at the point-of-care to ensure appropriate dose titration required to mitigate the pain experience without overprescribing. The National Institutes of Health (NIH) have …
-
Investigating the Contribution of the Inflammasome to Persistent Pain States
Neuropathic pain, a debilitating condition, occurs as a consequence of nerve injury with symptoms such as spontaneous pain, hyperalgesia, and allodynia commonly reported. In animal models of peripheral nerve injury, there is accumulation and proliferation of microglial cells in the injured spinal …
-
NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein
… demonstrated that experimental peripheral inflammatory pain (PIP), induced by subcutaneous plantar injection of λ-carrageenan in Sprague Dawley rats, results in increased expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously expressed at …
-
Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
Abstract : Contrary to popular beliefs, chronic pain is not only a set of symptoms, but a bona fide pathology that the drugs currently available are not sufficient to efficiently relieve. There is thus a need to modify our approach to discover new analgesic agents, taking into consideration the …
-
Proton-sensing G protein-coupled receptor signalling in inflammation
… heightened nociception associated with chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Extracellular protons can coordinate cellular responses through a number of proton-sensitive receptors including both ion channels and G protein-coupled receptors, …
-
NTS2-selective analogs as an alternative treatment to chronic pain
Chronic pain is a major health problem affecting 20% of the world population. Consequently, this medical condition represents an enormous burden on the quality of life and mental health of affected patients, not to mention the astronomical cost to the economy and healthcare systems. Mild analgesics …
-
The Interaction of Pain and Morphine on Analgesia, Locomotion, and Cognitive Functioning
… best weapon against severe intractable pain, but prolonged use of these medications can be complicated by side effects like tolerance and mental clouding which, themselves, can be disabling. The present study examined the independent and combined effects of inflammatory pain and opioid …
-
Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
… were prepared and tested for their anti-inflammatory pain with the goal of discovering a novel lead compound. Specifically, cannabimovone was prepared in biomimetic fashion and displayed a remarkable ability to stimulate the production of cytokines in a BV-2 mouse microglial cell line …
-
The Oxford Shoulder Score: Cross-cultural adaption and translation validation into Afrikaans
… consecutive patients with either degenerative or inflammatory pain of the shoulder were prospectively enrolled. Patients were evaluated by completing the Afrikaans OSS, Constant-Murley, quickDASH, and the Subjective Shoulder Value (SSV) scores. Comprehensibility and acceptance, as well as any …
-
Identification of Novel CCR4 Antagonists Through Inhibition of CCL22-Induced Cell Migration
Post-surgical pain (PSP) is a complication of surgical procedures and one of the main contributors to chronic PSP in cases of inadequate management. Thus, PSP management planning is essential to anesthetic and perioperative care to prevent the transition from acute to chronic pain. Concerns about …
-
FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS
… has analgesic properties in a mouse model of inflammatory pain.
-
Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs
… and has also been used for neuropathic and inflammatory pain. In addition, off-label use has increased for various disorders, including mental disorders, such as anxiety disorders and bipolar disorders as well as chronic back pain. Gabapentin prescriptions have increased markedly in recent …
-
Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
… in the development and maintenance of chronic pain. mGlu5 is expressed at synapses throughout the pain neuraxis where it is believed to modulate the function of ion channels that underlie nociceptive transduction and transmission. Injections of mGlu5 agonists cause hypersensitivity or …
-
Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
… in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may reflect an overreliance on preclinical …
Page 1 of 2