Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"inflammatory microenvironment"”.
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Study of cellular mechanisms of inflammation and the involvement of mast cells in disease
… From an analytical perspective, the inflammatory response presents several technical challenges. The inherent complexity of the immune system makes unraveling the pathogenesis of inflammatory disease a particularly challenging endeavor. An ability to detect and monitor immune cell …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… risk factors for development of colon cancer is inflammatory bowel disease. Inflammatory microenvironment is an essential component of most tumors. Interestingly, high levels of the pro-inflammatory mediator leukotriene D4 (LTD4) in association with its receptor CysLT1 goes with poor prognosis …
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Engineered [beta]TCP-binding HER-family protein fusions and their use for improving osteoprogenitor- mediated bone regeneration
… (CTPs) can be limited in large defects by the inflammatory microenvironment. Ligands that can improve CTP survival and other relevant upstream processes like colony formation and proliferation should advance bone healing. One such ligand is the Epidermal Growth Factor (EGF). EGF, when presented …
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RNA Knockdown of the Immune Checkpoint VISTA Promotes Tumor Regression
… and enhanced T cell responses within the tumor microenvironment (TME). Several limitations for antibody blockade of VISTA exist, including its rapid turnover on and off the cell surface, pH-dependent binding to its receptors, and potential toxicities resulting from VISTA blockade in non-myeloid …
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Characterising Heterogeneity of Glioblastoma using Multi-parametric Magnetic Resonance Imaging
… were identified, which displayed hypoxic and pro-inflammatory microenvironment. Higher lactate in the low perfusion compartment with restricted diffusion was associated with a worse survival (PFS: HR = 2.995, P = 0.047; OS: HR = 4.974, P = 0.005). III. Using an unsupervised multi-view feature …
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… nerve dysfunction and HL. Furthermore, the inflammatory microenvironment of SCH was explored through the setup of SC-macrophage co-culture paradigm. We found a significant cross-talk between SCs and monocytes: naïve SCs were shown to modulate monocytes and macrophages toward an …
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The role of the Dnmt3aR882H mutation in the evolution of clonal haematopoiesis.
… Long-Term Haematopoietic Stem Cells (LT-HSCs) to inflammatory "stress" in vitro and in vivo. We have also em- ployed bulk LT-HSCs genomics studies to interrogate differences in the transcriptional landscape in response to inflammation. We have demonstrated that Dnmt3a-mutant LT- HSCs have a …
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KINETICS AND PROTEOLYTIC SIGNATURES OF HISTATIN 5 DEGRADATION IN SALIVA AND GINGIVAL CREVICULAR FLUID IN PERIODONTAL HEALTH AND GINGIVITIS
… and host-derived enzymes, amplified by the inflammatory microenvironment. P. gingivalis was detected in only 13.3% of gingivitis and 11.1% of healthy samples, challenging its presumed ubiquity and supporting community-driven dysbiosis. Proteomic analysis identified significantly greater …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… system (CNS). At the lesion site, the hostile microenvironment which develops within the CNS prevents regeneration. Current therapeutic strategies for traumatic CNS injury aim at patient stabilization and symptoms management, however without promoting neural tissue regeneration. Ongoing studies …
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Determinants of clinical phenotype in myeloproliferative neoplasms
… analysed to determine the contribution of the inflammatory microenvironment to phenotype and progression risk. Results: A total of 2035 patients were included in the analysis. 33 genes had driver mutations in at least 5 patients, with mutations in JAK2, CALR, or MPL being the sole abnormality …
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… be maintained in the absence of the bone marrow microenvironment and allowed the identification of key factors dispensable for HSC function (Chapter 3). Next, to understand the role of extrinsic regulators in disease evolution I shifted focus to characterising the cytokine microenvironment in …
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The Recruitment and Function of Tumor Microenvironment Components During Gastric Carcinogenesis
… induces a a wide array of chronic low grade inflammatory responses, some of which directly contribute to carcinogenesis and some of which do not. To tease out the role of various processes, we have compared and contrasted models that recapitulate H. felis infection or synergize with it, …