Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 241 for “"inflammatory mediators"”.
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Inflammatory mediators in diabetic retinopathy
… Hyperglycemia in the retina activates pro-inflammatory pathogenetic pathways i.e., the polyol, PKC, hexosamine, and RAS pathways, as well as AGE formation. Molecular changes result in blood flow alterations, formation of reactive oxygen species and oxidative stress, induction of …
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Inflammatory Mediators Associated with Pre-eclampsia
… has been suggested that the increased level of inflammatory cytokines might be related to pre-eclampsia. Therefore, the purpose of this research was to prove the relationship between the inflammatory molecules and pre-eclampsia. MATERIALS AND METHODS: The presence of macrophages in placental …
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Targeting pro-inflammatory mediators to treat visceral pain
… in gastrointestinal (GI) diseases, like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), but many current analgesics produce GI side effects. To develop much needed, novel treatments, further understanding of the pro-inflammatory mediators and mechanisms underpinning …
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… other pro-atherogenic molecules, this prolonged inflammatory state in atherosclerosis results in the deterioration of the endothelium, increasing the risk of focal thrombosis. Current treatment strategies to address the role of thrombin in atherosclerosis, despite efficacy of anticoagulant …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… increasing endothelial barrier dysfunction. Many inflammatory mediators dictate the course and gravity of the response by inducing endothelial cytoskeletal reorganization, such as induction of actin stress fibers, cell rounding and contraction, and dissociation of interendothelial junctions.</p> …
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Effect of nitric oxide and inflammatory mediators on axonal transport
In dieser Arbeit wurde der Einfluss der Aktivierung von Microgliazellen auf den Transport von Organellen, Vorläufervesikel und Mitochondrien in Axonen untersucht. Mikrogliazellen sind mitverantwortlich für die Immunreaktionen im Gehirn und setzen dabei Stickstoffmonooxid und entzündliche Mediatoren …
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Functional Characterization of the Avian Inflammatory Mediators Nod1, MIF and IL-22
… molecules, resulting in the production of pro-inflammatory cytokines, chemokines, and anti-microbial peptides. A candidate sequence of chicken Nod1 (ChNod1) was identified with no current evidence of ChNod2. Stimulation of transiently overexpressed ChNod1 and its mutants with mammalian …
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Proteases, antiproteases and other inflammatory mediators associated with Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a complex heterogeneous lung condition characterised by chronic inflammation and a reduction in airflow. COPD is diagnosed by measuring patient airflow obstruction, a late developing symptom, by which time irreversible lung damage has already …
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Role of Fas/FasL, inflammatory mediators and LPS-activated macrophages in human neutrophil apoptosis
… to bacterial infection as well as generalised inflammatory stimuli, such as pancreatitis. At sites of infection, phagocytosis of bacteria by neutrophils enhances their subsequent apoptosis and clearance by macrophages however at inflammatory sites, the lifespan of the neutrophil is influenced …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… and clinical data show an acute and prolonged inflammatory response in the brain after a stroke. Several investigators have reported that inflammation evolves within a few hours after stroke, and plays an important role in the development of the cerebral lesions [6]. This inflammatory reaction …
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The Effects of Long Term Walnut Consumption on Levels of Plasma Tocopherols and Inflammatory Mediators
… on plasma levels of tocopherols and the inflammatory mediators interleukin-1β (IL-1β ), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and Creactive protein (CRP) in healthy participants. Ninety participants were recruited into a 12-month randomized crossover intervention study, …
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The Effect of Adenosine on the Production of Inflammatory Mediators By Macrophages in Response to Candida Albicans
… patients. Upon activation, macrophages secrete inflammatory mediators, including the cytokines tumor necrosis factor alpha (TNF-α) and interleukin 1 (IL-1). Adenosine is an important physiological molecule that can modulate the function of macrophages by altering the amounts of cytokine …
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Toxicological effects of metal oxide nanoparticles in combination with microbial components and inflammatory mediators on intestinal epithelial cells
<p>Inflammatory bowel disease (IBD) are inflammatory disorders with multi-factorial etiologies and many contributing factors (e.g., genetic disposition, luminal antigen, gut microbiota, and environment) that occur in about 1 in 300 persons in the United States and other western countries, but its …
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The Effect of Walnuts Compared to Fatty Fish on Plasma and Erythrocyte Fatty Acid Composition, Lymphocyte Subsets and Inflammatory Mediators
… effects of walnuts vs. fatty fish on circulating inflammatory markers, on lymphocyte subsets, on plasma concentrations of eicosanoids precursor polyunsaturated fatty acid and on erythrocyte membrane fatty acid composition. Under controlled metabolic feeding conditions and randomized crossover (3x3 …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… fasting was able to reduce gene expression of inflammatory IL-1α in the brain, here we looked at liver and adipose in addition to brain and uncovered a major up-regulation of IL-1 endogenous inhibitors, IL-1RA and IL-1R2 in peripheral tissues. These findings imply that attenuation in sickness …
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The effects of a combined exercise programme aerobic and resistance on blood glucose, incretin, metabolic and inflammatory mediators that could control the diabetes and improve insulin sensitivity in type 2 diabetes patients
… Finally, exercise has different effect on the inflammatory markers, it shows elevation of IL-6 in T2D after 6 weeks of exercise. CRP represent significant reduction after 6 weeks as well which illustrates that exercise has good impact in decreasing inflammation by reducing CRP. Moreover, there …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… inhibition of NADPH oxidase activation and pro-inflammatory mediators expression. Here, we observed the expression of pro-inflammatory mediators and IL-10 in the cerebral cortex of transgenic mouse model of AD (APP/PS1). In transgenic mice, microglia and astrocytes were activated synchronously …
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Effects of vitamin D on inflammation and oxidative stress in airway epithelial cells
… vitamin D has been shown to modulate a number of inflammatory mediators which are important in COPD pathology. Together, these suggest that vitamin D may be beneficial in COPD. Airway epithelial cells play a central role in COPD pathogenesis and have been shown to constitutively activate vitamin …
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A Study on the Effect of Peroxisome Proliferator-Activated Receptors (PPARs) Activation in Cultured Rat Brain Glial Cells
… reports on the involvement of PPARs during inflammatory process, but the exact mechanisms of action are largely unknown. In this study, we tested the role of PPARs, PPAR-？ and -？, on the development of LPS- and IFN-？-mediated inflammation in cultured rat brain glial cell. In LPS-stimulated …
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