Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"inflammatory genes"”.
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Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… induce a strong but transient induction of pro-inflammatory mediators, low doses of endotoxin result in a mild but chronic induction of pro-inflammatory genes. The central hypothesis of our study was that if low doses of endotoxin are capable of inducing mild prolonged inflammation, then a …
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Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages
<p>Interleukin-10 (IL-10) is an important anti-inflammatory cytokine acting to dampen macrophage activation during and after the immune response to microbial pathogens. During the innate immune response to gram-negative bacteria, macrophages are triggered to produce numerous pro-inflammatory …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… and immune cell interactions. In response to inflammatory stimuli, such as cytokines, endothelial cells become activated, promoting the recruitment and adhesion of leukocytes to the vessel wall. This process, involving a complex sequence of leukocyte capture, rolling, and transmigration, …
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Expression and Function of Basigin During Implantation in the Mouse
… production and inducing the expression of pro-inflammatory genes.
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Identifying sm22 as a key player in arterial diseases
… where inflammation and osteochondrogenesis are present. However, the role of this downregulation in arterial pathogenesis is unknown. Hypothesis : Downregulation of SM22 may actively contribute to arterial pathogenesis. Methods : Five Sm22 knockout (Sm22<sup>-/-</sup>) mice and their …
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Role of PI3K and MAPK in Regulating the IL-10-Induced Temporal Transcriptional Program in LPS-Triggered Macrophages
… to host tissues associated with a prolonged inflammatory state, the cytokine interleukin-10 (IL-10) induces expression of a set of anti-inflammatory genes that act to inhibit expression of TLR-induced pro-inflammatory genes. While many of the IL-10-induced genes can be induced by IL-10 …
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Investigation into Toxoplasma gondii infection in relation to expression of neurodegenerative disease markers in natural mice populations
… the expression of a range of key autophagic and inflammatory genes associated with neurodegenerative diseases in humans. Human brain tissue from the hippocampus and frontal lobe regions was obtained from 45 cadaveric specimens and analysed for the presence of Toxoplasma gondii cysts using visual …
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Role of the glucocorticoid receptor and HIV-1 Vpr in inflammatory gene expression and HIV-1 LTR transcription in response to dexamethasone and progestogens
… and P4, increases mRNA expression of the anti-inflammatory GILZ and IκBα genes. Similarly, MPA unlike NET-A, decreases mRNA expression of the pro-inflammatory IL-6, IL-8 and RANTES genes, and IL-6 and IL-8 protein levels. The predominant steroid receptor expressed in the cervical cell lines …
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The immunomodulatory effects of the garlic organosulfur compounds allicin and Z-ajoene in an in vitro murine model of LPS-induced inflammation
… world. Chronic inflammation facilitates tumourigenesis and cancer progression by providing an environment conducive to cancer. Dysregulation of the immune response, and particularly inflammation, is an important part of this process. Garlic (Allium sativum) has been used for centuries as both a …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… NCC is neuroinflammation; however, the neuroinflammatory mechanisms underlying this disease remain grossly understudied, and how innate immune cells respond to this infection is still debated. One of the reasons for this is that there is a lack of reliable experimental models of inflammation …
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… Moreover, Abro1-null mice show signs of inflammatory response such as enlarged spleens, increased numbers of T cells and B cells, elevated levels of IL6 and TNF-alpha in the blood, and increased immune cell infiltration in major organs. Recently, it has been shown that genomic instability …
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Dissecting the Role of Novel O-GlcNAcylation of NF-κB in Pancreatic Cancer
… It mediates the transcription of oncogenic and inflammatory genes that facilitate multiple PDAC phenotypes. Thus, a better understanding of the mechanistic underpinnings of NF-κB activation holds great promise for PDAC diagnosis and effective therapeutics. Here, we report a novel finding that …
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Die Rolle der Thrombozyten- und Leukozyten-Endothelzell-Interaktion in der Atherogenese
… leukocyte-endothelial cell-interaction in atherogenesis - an in vivo-study in the ApoE-knock-out-mouse - Platelets play a crucial role in thromboembolic complications of advanced atherosclerotic lesions but their involvement in the initiation of the atherosclerotic process in unclear. Platelet …
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Mechanisms of glucocorticoid pro-inflammatory effects on CCL20: crosstalk and synergy
… are steroid hormones widely prescribed to treat inflammatory disorders and are regarded as anti-inflammatory molecules. GCs classically induce the expression of antiinflammatory genes, while repressing pro-inflammatory genes via its endogenous cell receptor; the glucocorticoid receptor (GR). …
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Regulation of Synergistic Inducible ABIN-3 Gene Expression in Response to IL-10 and LPS
… responses. The activation of macrophages by pro-inflammatory stimuli, such as bacterial LPS, is mediated through changes in the expression of genes that function to promote inflammation. Pro-inflammatory signaling and gene expression is tightly regulated through the parallel induction of …
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Characterizing 3D epigenomes in pathological conditions
… is the compromising of interferon-stimulated genes and an increase of proinflammatory genes, paralleling a rise in H3K4me3 modifications at the promoters of pro-inflammatory genes. This investigation not only characterizes the impact of SARS-CoV-2 acute infection on host chromatin but also …
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Chromatin Control of the Antiviral Response to Influenza
… PAF1 is inducibly recruited to anti-viral and inflammatory genes during infection, and that its presence coincides with the recruitment of RNA polymerase II (Pol II) and the expression of target genes. Altogether, our findings imply that exploiting histone mimicry could be a general strategy …
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An investigation into the role of Bcl-3 in toll-like receptor signalling
… the expression of hundreds of immune and pro-inflammatory genes. TLRs are critical in mounting a defence against invading pathogens however, strict control of TLR signalling is vital to prevent host damage from excessive or prolonged immune activation. In this thesis the role of the IκB …
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Investigating the potential of Sodium Butyrate to Control Salmonella Enteritidis in Poultry
… are microbial metabolites known to modulate inflammatory response. In this dissertation, the effect of sodium butyrate on the colonization of SE in primary chicken enterocytes and chicken macrophages was investigated. In addition, the effect of sodium butyrate on the proteome of primary …
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
… are found in many transcripts that encode for inflammatory genes, including TNF, GM-CSF, and IL-8. Pathogens evolve and devise mechanisms to subvert the immune response of the host to aid in its infection. Bacillus anthracis is one such infectious agent that can disable numerous arms of the …
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