Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 316 for “"inflammatory cytokine"”.
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Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases
… fatty acids (PUFA) have therapeutic effects in inflammatory diseases, however the specific mechanisms by which they exert these effects have not yet been defined. Several studies have shown involvement of toll llke receptor TLR2 and TLR4 in some of these inflammatory diseases shown to be …
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
… heart and kidneys, specifically with respect to inflammatory cytokine production. Endothelial cells, exposed to various glucose levels, and MALAT1 knockout mice and controls, with or without streptozotocin-induced diabetes were examined. Endothelial cells cultured with high glucose, and renal and …
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Characterizing the pro-inflammatory cytokine response by dendritic cells upon exposure to PrP proteins
Dendritic cell (DC) interaction with infectious prions (PrPSc) represents an important part of prion pathogenesis. Previous studies have shown that DCs are likely among the first immune cells to interact with PrPSc after oral exposure. This study looks at the initial exposure of PrPSc on DC …
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Cell death and Pro-inflammatory Cytokine Release of Rat Microglial Cells by Naegleria fowleri
… by (51)^Cr release assay. In addition, the pro-inflammatory cytokine release from microglial cells in co-culture system was estimated. As results with a light and electron microscopes, most of microglial cells were severely destroyed by N. fowleri lysate, showing the necrotic (above 85%) and …
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Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity
… toxic effects in a background reflecting in vivo inflammatory conditions. This background incorporates bacterial lipopolysaccharide (LPS) administration along with inflammatory cytokines (tumor necrosis factor, interferon y, interleukin-1 a, interleukin-113, and interleukin-6) previously shown to …
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
Inflammatory cytokine expression is often increased under pathological conditions in the CNS. Tumor necrosis factor-$\alpha$ (TNF) is an inflammatory cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating …
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Investigating the molecular underpinnings of major depressive disorder and the utility of biomarkers in the inflammatory cytokine pathway as aids for clinical diagnosis and treatment selection
… differences in the transcription of inflammatory<br/>cytokines in the blood of MDD patients, bipolar disorder patients and controls,<br/>revealed disorder-specific differences in chemokine (C-C motif) ligand 24 and CC<br/>chemokine receptor type 6 which specifically differentiated MDD …
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The role and host-directed targeting of long non-coding RNAs in macrophage polarization during Mycobacterium tuberculosis infection
… by gapmeRs reduced Mtb growth and anti-inflammatory cytokine production mediated by increased apoptosis, nitrite and pro-inflammatory cytokine production in IL-4/IL-13 prestimulated mouse macrophages. Whereas knockdown of lncRNA-125 in IFN-γ pre-stimulated mouse macrophages favoured Mtb …
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Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury
… species (ROS/RNS) that in turn drives an inflammatory response and consequently cell death through hyper-activation of poly (ADP-ribose) polymerase (PARP-1). The purpose of this study was to investigate and counteract pulmonary dysfunction associated with nitrosative stress generated after …
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The innate response to fungal infection
… receptors, ultimately resulting in pro and anti-inflammatory cytokine production.<br/>Following Dectin-1 activation, I show that blocking SYK activity with SYK inhibitor II<br/>prevents MAPK and NF?B signalling, causing a reduction in both pro and antiinflammatory cytokine production. However, …
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Inflammatory Proteins, Genetic Variation, and Environmental Influences on Health Care Associated Infection Development in Sepsis
… impact of baseline systemic inflammation (pro‑inflammatory cytokine, anti‑inflammatory cytokine, and their ratio), genetic variability, and environment on the development of health care associated infections (HAI) among sepsis patients during their ICU stay (up to 28 days).</p> …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… vapours induce significant cytotoxicity, promote inflammatory cytokine release and reactive oxygen species generation. Inflammatory complexes called the inflammasomes are known to initiate and potentiate inflammation and are classically activated by two signals, usually a PAMP (Pathogen Associated …
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Characterisation of the HIV inhibitory activity of vaginal lactobacilli isolates from young South African women at high risk of HIV acquisition
… do not exist. BV is associated with upregulated inflammatory cytokine levels in the female genital tract (FGT), which in turn may increase HIV infection risk by recruiting and activating HIV target cells, reducing epithelial barrier function and directly promoting HIV replication. Lactobacillus …
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RNA-binding proteins mediate anti-inflammatory regulation of vascular disease
… of FXR1 increases abundance and stability of inflammatory mRNAs, while overexpression of FXR1 reduces their abundance and stability. RNA-EMSA and RIP demonstrate that FXR1 directly interacts with an ARE and a previously uncharacterized element in the 3’UTR of TNFa. FXR1 expression is increased …
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Biological activity of palmitoylcarnitine in prostate cancer
… of palcar could induce gene expression of the inflammatory cytokine IL-6, and induce its secretion in PC3 cells. This was associated with the rapid influx of Ca2+. Through the use of various metabolic inhibitors, it was shown that Ca2+ influx includes the activation of G-protein coupled …
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Neuroimmune and Developmental Mechanisms Regulating Motivational Behaviors for Opioids
… and increases microglial expression of the anti-inflammatory cytokine interleukin-10 (IL-10). The experiments described in this dissertation were thus designed to address if inflammatory signaling in the NAc may underlie the effects of early-life experience on later-life opioid drug-taking. The …
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Enhancing Seafood Quality and Safety by Reducing Reliance on Antibiotics: Applying a Novel Antibody in Tilapia
… of interleukin-10 (IL-10), an anti-inflammatory cytokine. The anti-inflammatory function of IL-10 has been shown to allow persistence of gastrointestinal pathogens. Tilapia were fed the novel diet and were challenged via bath immersion or oral gavage with A. hydrophila. Four trials …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… such as E. coli. In the case of mucosal inflammatory pathologies, such as Crohn’s disease, this state of tolerance is broken, resulting in destruction of gut mucosal tissue where the macrophage phenotype has been altered from a regulatory M2-like subset phenotype to an inflammatory …
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Moderate Acute Malnutrition: Inflammatory Response, Microbiota, and Potential Treatments
… the pathology of SAM and resultant attenuated inflammatory response have been characterized, there is minimal and often conflicting data available about the effects of MAM on inflammation and response to inflammatory stimuli. In this work, we observed increased inflammatory cytokine production …
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