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Showing 1 to 20 of 20 for “"inflammatory breast cancer"”.
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Exploring inflammatory breast cancer
Contains fulltext : 217372.pdf (Publisher’s version ) (Open Access)
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Inflammatory Breast Cancer: The Immune Perspective
<p>Inflammatory breast cancer (IBC) is the most insidious form of locally advanced disease. Although rare and less than 2% of all breast cancer, IBC is responsible for up to 10% of all breast cancer deaths. Despite the name, very little is known about the role of inflammation or immune mediators in …
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Identification and Targeting of Therapeutic Resistance Mechanisms in Inflammatory Breast Cancer
<p>Inflammatory breast cancer (IBC) is a rare and highly aggressive form of breast cancer that is characterized by survival signaling through overexpression and/or activation of the epidermal growth factor receptors EGFR/ErbB1 and Her2/ErbB2 and defects in the apoptotic program. The development of …
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Aspirin Use Is Associated with Improved Outcomes in Inflammatory Breast Cancer Patients
PURPOSE: Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer and has a high propensity for distant metastases. Our previous data suggested that aspirin (ASA) use may be associated with reduced risk of distant metastases in aggressive BC; however, there are no reported …
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
<p>Triple-negative (TNBC) and inflammatory (IBC) breast cancer are the most aggressive forms of breast cancer, accounting for 20% and 10% of cancer-related deaths, respectively. Among IBC cases, 30% are additionally classified with TNBC molecular pathology, a diagnosis that significantly worsens …
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Role of Mir-19A Released By Inflammatory Breast Cancer Cells In The Regulation of Dendritic Cell Functions: In Vitro Model of Crosstalk In The Tumor Microenvironment of Inflammatory Breast Cancer
<p>Inflammatory breast cancer (IBC) is a rare but very aggressive form of locally advanced breast cancer (1-6% of total breast cancer patients in United States), with a 5-year overall survival rate of only 40.5%, compared with 85% of the non-IBC patients. So far, a unique molecular signature for …
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Risk-Factor Induced Changes In The Breast Microenvironment Facilitate Inflammatory Breast Cancer Progression and Lymphovascular Invasion
<p>Inflammatory breast cancer (IBC) is a rapidly progressing, rare and highly lethal form of breast cancer. IBC is a clinical diagnosis, requiring >1/3 involvement on the affected breast and/or skin by erythema, and disease onset of < 6 months. The clinical symptoms of IBC vary in severity and …
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Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
<p>Apoptotic dysregulation is a hallmark of cancer cells. The inability of cancer cells to undergo apoptosis may lead to therapeutic resistance. Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer that is often characterized by ErbB2 overexpression and ErbB2 activation. …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
<p>Inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC) are two highly aggressive breast cancer subtypes associated with a poor outcome. Despite sensitivity to current treatment, these breast cancers subtypes have a high recurrence rate and proclivity to metastasize early. The …
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Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
<p>Inflammatory breast cancer (IBC) and triple-negative breast cancer (TNBC) are two highly aggressive breast cancer subtypes associated with a poor outcome. Despite sensitivity to current treatment, these breast cancers subtypes have a high recurrence rate and proclivity to metastasize early. The …
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Role of shNDPK and E-Cadherin in Growth and Metastasis of an Inflammatory Breast Cancer Model (MARY-X)
MARY-X, an inflammatory breast cancer (IBC) murine xenograft, exhibits the formation of florid lymphovascular emboli in vivo and spheroid formation in vitro. IBC is highly invasive and metastatic and our model presents the same in mice as it does in human. Therefore, studying the molecular …
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Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
… FOR THE INVASIVE PHENOTYPE </p> <p>OF INFLAMMATORY BREAST CANCER</p> <p>by</p> <p>BERNADETTE C. VICTOR</p> <p>December 2011</p> <p>Advisor: Dr. Bonnie F. Sloane</p> <p>Major: Cancer Biology </p> <p>Degree: Doctor of Philosophy</p> <p>Inflammatory breast cancer (IBC) is an aggressive, …
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Simvastatin Does Not Sensitize Ibc3 Her2+ Inflammatory Breast Cancer Brain Metastases to Whole Brain Irradiation In An Immunocompromised Mouse Model
<p>Retrospective data analysis suggests that inflammatory breast cancer (IBC) patients who take statins have better locoregional control after radiotherapy than those who do not [23]. Our lab has previously demonstrated that simvastatin radiosensitizes IBC cells in vitro [23], and brain metastases …
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Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
<p>Aggressive breast cancers, triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC), metastasize at a high rate and are notoriously resistant to standard treatments. Research has shown diets high in cholesterol increase the incidence of aggressive breast cancers and pre-clinical …
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
<p>Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive breast cancer subtypes. The tumor microenvironment (TME) is critical in driving these aggressive breast cancers' clinical phenotype and aggressiveness. Therefore, we explored novel actionable …
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Photodynamic Therapy As An Effective Therapeutic Approach In Mame Models Of Triple Negative And Inflammatory Breast Cancers
… including endobronchial and esophageal cancers that are</p> <p>accessible to light. Triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC)</p> <p>are aggressive and lethal subtypes of breast cancer that spread to chest wall and dermal</p> <p>lymphatics, respectively, …
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Prophylactic Cranial Irradiation Reduces The Incidence of Brain Metastasis In A Mouse Model of Metastatic Breast Cancer
… survival in select patients with small cell lung cancer and acute lymphoblastic leukemia. A population of breast cancer patients – stage IV, HER2+ or triple-negative – has emerged as having a high risk of developing brain metastases. Because only 10-20% of breast cancer patients diagnosed with …
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Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
… study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was also to investigate, through immunohistochemistry, the expression and distribution of nestin in T4 breast cancer, in order to determine its association with clinical and pathological …
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Carcinoma inflamatório de mama em mulheres e cadelas: análise comparativa e perspectivas terapêuticas
Inflammatory mammary carcinoma (IMC) is a clinic-pathological presentation of breast cancer characterized by rapid progression, aggressiveness, and poor prognosis, affecting both women and female dogs. Despite significant advances in understanding the pathogenesis and management of IMC in humans, …
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Gene Set Analysis of Post-Lactational Mammary Gland Involution Gene Signatures In Inflammatory and Triple Negative Breast Cancer
… that initiates the development of precancerous mammary cells and promotes the progression of precancerous cells into cancer cells. Moreover, epidemiological studies have found that triple-negative (TN) breast cancer (BC) is associated with lower frequency and duration of breastfeeding …