Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"inflammasome activation"”.
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Caspase isoforms in inflammasome activation
Inflammasomes are macromolecular signalling platforms composed of a receptor (for example NLRP3 or NLRC4), an adaptor (ASC) and effectors (caspases) that are thought to play critical roles in the host defence against microbial infections. Activation of inflammasomes leads to the processing of the …
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Rodent inflammasome activation by Toxoplasma gondii
… the parasite's ability to find a balance between activation of a host immune response and evasion of parasiticidal mechanisms. This balance is achieved through the modulation of host cell processes by parasite proteins secreted from specialized secretory organelles known as rhoptries and dense …
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The role of PLK1 in NLRP3 inflammasome activation
The NLRP3 inflammasome is a heteroprotein complex that assembles in response to a variety of DAMPs (Damage-Associated Molecular Patterns) and PAMPs (Pathogen-Associated Molecular Patterns). Activation of the NLRP3 inflammasome leads to pro-inflammatory cytokines (IL-1 and IL-18) release and …
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Molecular basis of NAIP/NLRC4 inflammasome activation by flagellin
… (S. Typhimurium) activates the NAIP/NLRC4 inflammasome and its contribution to the host protective immune response against salmonellosis. Inflammasomes are multi-protein complexes formed in response to the activation of pattern recognition receptors (PRRs). The NOD-like receptor …
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The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies using generic targeting of IL-1, the end product of multiple inflammasome …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… generation. Inflammatory complexes called the inflammasomes are known to initiate and potentiate inflammation and are classically activated by two signals, usually a PAMP (Pathogen Associated Molecular Pattern) and a DAMP (Danger Associated Molecular Pattern) which result in the processing of …
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Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
Activation of inflammasome leads to pyroptotic cell death thereby eliminating the replicative niche of virulent pathogens, a process integral to innate immunity. While inflammasome-associated cytokines such as IL-1β and IL-18 have an established role in T cell function, whether inflammasome …
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Particulates Initiate Immune Response Via Inducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation
… I hypothesize that liposomes activate NLRP3 inflammasome in macrophages, which results in the release of interleukin 1β (IL-1β), a proinflammatory cytokine that plays a key role in innate and adaptive immune responses.</p><p>To test my hypothesis, I determined the ability of inducing IL-1β …
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Inflammasome activation in THP-1 target cells triggered by pathogenic Naegleria fowleri
… forebrain tissue. To investigate what kinds of inflammasome molecules are expressed in target cells due to N. fowleri infection, human macrophage cells (THP-1 cells) were co-cultured with N. fowleri trophozoites under the non-contact system, and consequently IL-1β production was estimated. By …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
Activation of pattern recognition receptors on dendritic cells (DCs) and macrophages leads to secretion of cytokines that control activation and differentiation of CD4+ T cells. While IL-12 is critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 …
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Exploring the Role of the Inflammasome Pathway in Diabetic Retinopathy
… domain (NOD)-like receptor protein 3 (NLRP3) inflammasome activation, which orchestrates inflammation in the innate immunity, is associated with DR. However, the impact of inflammasome activation on DR progression remains uncertain. Therefore, this thesis seeks to investigate the role of …
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The Activation of the Inflammasome during Rickettsial Infection
… investigated the canonical and non-canonical inflammasome activation by rickettsiae in mouse macrophages. The central hypothesis is that activation and priming by lipopolysaccharide (LPS) of caspase-11 and ASC-dependent inflammasomes in macrophages is essential for host clearance of rickettsia …
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Intracellular triggering of inflammation by the extracellular bacterium Pseudomonas aeruginosa
… protein complexes, the Nod-signalosome and inflammasomes. These lead to the activation of NF-κB and the activation of caspase-1 and subsequent proteolytic processing of interleukin-1β (IL-1β) into its mature form. Both processes contribute to the inflammatory response following infection. In …
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Transcriptional Regulation of NLRC4 Inflammasome by IRF8
<p>The NLRC4 inflammasome is a crucial part of the innate immune response against bacterial infections. We found that NLRC4 inflammasome activation in bone marrow-derived macrophages (BMDMs) is greatly dependent on interferon regulatory factor 8 (IRF8). NLRC4-mediated caspase-1 activation and …
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THE LYSOSOMAL AMYLOID AGGREGATION OF B2-MICROGLOBULIN PROMOTES MULTIPLE MYELOMA PROGRESSION: A MOLECULAR FOCUS ON THIS PRO-CANCER MECHANISM
… The resulting lysosomal damage induces NLRP3 inflammasome activation which sustain inflammation and malignant plasma cell proliferation. This thesis investigates the link between β2m fold stability and aggregation propensity under lysosomal-like conditions, and the resulting inflammatory …
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Molecular Mechanisms Involved in Interleukin-1β Release by Macrophages Exposed to Metal Ions from Implantable Biomaterials
… family pyrin domain-containing protein 3 (NLPR3) inflammasome, which is responsible for interleukin(IL)-1β production through caspase-1. Furthermore, these ions are known to induce oxidative stress, and inflammasome priming is known to involve nuclear factor kappa-light-chain-enhancer of activated …
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The role of metabolism in the pathogenesis of adherent invasive Escherichia coli (AIEC)
… We also show that HM605 activates the inflammasome, a major driver of inflammation in mammals. Specifically, we show that macrophages infected with HM605 produce significantly higher levels of the pro-inflammatory cytokine IL-1β than macrophages infected with a non-AIEC strain, and we …
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NLRP3 in Renal Injury and Inflammation
… in fibrosis and kidney failure. The Nlrp3 inflammasome has been implicated in the innate immune response to cellular injury and represents a potentially important pathway in the pathogenesis of CKD. The central hypothesis of this thesis is that NLRP3 plays a significant role in renal …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… both of which contribute to transcriptional activation of BRD4’s target genes. BRD4 has been implicated in the dysregulated transcription of oncogenes and inflammatory genes during disease progression; thus, the small molecule inhibitors that target the bromodomains of BRD4, as well as other …
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