Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"infectiousness"”.
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Understanding risk factors for HIV-1 infectiousness and transmission:prospective studies in HIV-1 serodiscordant couples
… biologic factors associated with increased HIV-1 infectiousness among heterosexual HIV-1 serodiscordant couples. The specific aims include 1) evaluating whether specific characteristics of HIV-1 serodiscordant couples could be used to defined a higher-risk subgroup for targeted prevention …
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Quantifying the Effect of Disease Characteristics on the Outcomes of Interventions Using Mathematical Modelling
… characteristics, such as transmissibility and infectiousness. These characteristics are crucial in determining whether there will be a local outbreak of the disease or if it has the potential to evolve into a global pandemic. Understanding these characteristics is essential in devising public …
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Nanomechanical Analysis of Coronavirus Spike proteins and Correlation with Infectivity and Lethality
… of SARS-CoV-2 circulates globally, estimates of infectiousness and lethality of newly emerging strains are important. Here, we provide a novel way to develop a deeper understanding of coronavirus spike proteins, connecting their nanomechanical features – specifically the vibrational spectrum and …
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Automated Fluorescence Microscopy Determination of Mycobacterium Tuberculosis Count via Vessel Filtering
… algorithm is more accurate on the field level infectiousness accuracy, based on F1-score results, and has a high visual semantic accuracy.
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Investigating synergy: Mathematical models for the coupled dynamics of HIV and HSV-2 and other endemic diseases
… HIV infection and that co-infection may increase infectiousness. Accordingly, antiviral treatment of people with HSV-2 may mitigate the incidence of HIV in populations where both pathogens occur. To better understand the epidemiological synergy between HIV and HSV-2, we formulate, in Chapter 2, a …
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Study of enteric virus infection and parenteral vaccines in the gnotobiotic pig model
… and fecal consistency to evaluate the virus infectiousness and associated diarrhea. The Log10 ID50 and DD50 were determined based on various mathematical models to be between 3.11 to 3.76, and 3.37 to 4.87 RNA copies, respectively. The Beta-Poisson was identified to be the best-fitting …
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Approaches for Mycoplasma hyopneumoniae detection, control, and molecular characterization
… for several months post-treatment. However, the infectiousness (or transmission potential) of the bacterium could not be assessed due to lack of transmission. Further research focused on the effect of control measures on M. hyopneumoniae transmission is warranted. Multiple-Locus Variable number …
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Cell surface interactions of Coxsackie A9 virus
… that this is related to viral tropism and infectiousness of the virus. CAV9 has also been reported to interact with the heparan sulphate/heparin class of proteoglycans (HSPG). This thesis describes work designed to improve our understanding of the involvement of a) the RGD motif and more …
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Investigating the Effectiveness of Supermarket Transmission Control Measures on the Spread of COVID-19 in the Presence of Super-Spreaders through Agent-Based Modelling
… of heterogeneous, individual-level chances of infectiousness, compliance, and consumer behaviours, allowing for a more realistic representation of real-world behaviours. The model used for analysis is built entirely in the NetLogo environment, designed to be interactive, adaptable to …
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Catching a glimpse: the visualization of Mycobacterium tuberculosis from TB patient bioaerosols
… detected provides a proxy measure of patient infectiousness, this method suggests that TiBr is a significant contributor to TB transmission. In developing a novel platform for the detection of aerosolized Mtb, this work has suggested the need to re-examine old assumptions about Mtb …
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Within Host and Multiscale Models of Usutu and SARS-CoV-2 Viral Infections with Animal Hosts
… of transmission. We further showed that viral infectiousness increases in a density dependent manner with viral RNA and that their relative ratio is time-dependent. Such information is useful for designing interventions. Our models of Usutu virus infection looked at differences between …
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A discrete-time waning immunity model for the spread of an immune escape pathogen
… that are related to waning immunity and pathogen infectiousness, such as a transmissibility parameter based on time since infection and a change in susceptibility based on time since last immune event (recovery from infection or vaccination). We show that these models can generate oscillatory …
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Effects of ambient temperature on mechanisms of pathogen transmission in house finches (Haemorhous mexicanus)
… Here I examined how temperature influenced host infectiousness and estimated exposure dose, as well as the behaviors of both sick and healthy birds. I found that donor birds in colder temperatures were slower to recover from infection, and thus remained infectious for longer, compared to donor …
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A novel cough aerosol sampling device for sputum-scarce individuals with tuberculosis
… to provide a semi-quantitative measure of infectiousness with known particle sizes and efficiencies. This proof-of-concept device shows CASS technology can be optimised for use in the clinical setting, thereby enabling it to become a more powerful sampling and research tool. The …
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Structured deterministic models applied to malaria and other endemic diseases
… model based on biological evidence is that the infectiousness of chronic infected individuals can be triggered by bites from even susceptible mosquitoes. The model analysis indicates that this assumption contributes greatly to the <em>R</em><sub>0</sub> and therefore needs to be further studied …
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A simulation model of antimalarial drug resistance
… information directly to determine human infectiousness rather than through using a gametocyte switching rate (constant multiplier used to convert parasite density to gametocyte density) as was done in Pongtavompinyo [2006]. The models developed in this thesis found that the existing …