Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"infection model"”.
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LncRNA discovery in the Listeria monocytogenes infection model
… cell innate immune response against microbial infection. These discoveries and the vast numbers of uncharacterized lncRNAs identified by high-throughput nextgeneration transcriptome sequencing technologies, set a precedence for further investigation and characterization of lncRNAs in infection …
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Development and Characterisation of an Immunocompetent Three-Dimensional Oral Mucosal Infection Model
Oral mucosal models are valuable tools for studying oral infection. Existing models have been implemented to study pathogen tissue invasion and resultant damage. These models fail to incorporate an innate immune component such as macrophages, essential for study of host response to infection. …
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Quasivirus Infection Model Identifies a Novel Role for Protein Arginine Methyltransferase 1 in the HPV Lifecycle
… with high efficiency. Alpha-papillomaviruses infections are ubiquitous in the global population, and HPV represents the most common sexually transmitted infection. Most Alpha-papillomaviruses cause benign infections. However, 12 Alpha-papillomaviruses (HPV16, HPV18, HPV31, HPV33, HPV35, HPV39, …
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Development of a novel infection model to test CSF1-Fc as a potential therapeutic for early onset sepsis
… dysregulation of the host immune response to infection, involving stages of hyperinflammation that mediate organ damage and dysfunction. Early onset sepsis (EOS) is defined as onset within the first 72 hours after birth. It is caused by ingestion or inhalation of infected fluids either in …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
… examines various in vitro monocyte / macrophage infection models used to study innate immune responses to B. pseudomallei. Several monocyte and macrophage models showed little or no significant differences between proinflammatory cytokines secreted in response to infection with B. pseudomallei …
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The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis
… immunity against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that of TNFRp75 in an M. tuberculosis aerosol inhalation infection was poorly defined. In this study the role of signaling through …
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Investigating the susceptibility of foreskin myeloid cells to ex vivo HIV infection
… immune cells, that are permissive to HIV infection5–8. In support of this, medical male circumcision (MMC), has been reported to confer up to 60 % risk reduction in HIV acquisition9–17. Most studies have focused on investigating blood lymphoid immune cells and their interaction with HIV-1, …
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Comparative pathogenesis of Yersinia enterocolitica biotypes
… depending on their pathogenicity in the mouse infection model. This project compared the pathogenic potential of Yersinia enterocolitica high pathogenic, low pathogenic and non-pathogenic biotypes. The HEp-2 laryngitic human epithelial cell line and the alternative infection model Galleria …
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Using age of infection models to derive an explicit expression for Ro
Using a multiple stage age of infection model, we derive an expression for the basic reproduction number, Ro. We apply this method to find Ro in analogous treatment models. We find, in the model without treatment, Ro depends only on the mean infective period, and not on the infective distribution. …
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Isolation of a Pseudomonas aeruginosa Aspartate Transcarbamoylase Mutant and the Investigation of Its Growth Characteristics, Pyrimidine Biosynthetic Enzyme Activities, and Virulence Factor Production
… decreased. In the Caenorhabditis elegans infection model the nematodes fed the ATCase mutant had increased mortality, as compared to nematodes fed wild type bacteria. These findings lend support to the hypothesis that changes in the pyrimidine biosynthetic pathway contribute to the …
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Novel Endodontic Disinfection Approach Using Nanotechnology
… use a recently developed Enterococcus faecalis infection model using root canal for evaluating iron oxide (Fe3O4) nanoparticles (NP) with biomimetic (catalytic) properties as a new antimicrobial endodontic treatment. We compared iron oxide NP bioactivity with currently used chemical modalities …
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Probing the role of histone acetylation in the evolution of pathogenicity in <i>Candida glabrata</i>
… advancement of modern medicine, invasive fungal infections are a growing cause of global mortality.<i> Candida glabrata</i> accounts for 25% of fungal infections in UK hospitals, second only to<i> C. albicans</i>. This number is expected to rise given current treatment challenges due to the …
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Stress response of porphyromonas gingivalis
… P. gingivalis cells recovered from a guinea-pig infection model.
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Investigating Hfq-dependent Small Regulatory RNA, Bsr34, and Its Roles in Brucella abortus Physiology and Pathogenicity
… but showed significant attenuation in a murine infection model, indicating a specific role in virulence. While an initial chloramphenicol sensitivity phenotype was inconsistent, expression profiling demonstrated that Bsr34 is specifically downregulated under envelope stress (polymyxin B) and …
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Molecular Basis of Corynebacterium Diphtheriae Virulence and Infection In The Caenorhabditis Elegans Model Host
… This is mainly due to lack of in vivo models of corynebacterial infection. As an alternative to mouse models as mice do not have functional receptors for diphtheria toxin, in this study I use Caenorhabditis elegans as a model host for C. diphtheriae. A simple C. elegans model would be …
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
<p>Mycobacterial infection leads to the formation of characteristic immune cell aggregates called granulomas. In humans and animal models, tuberculous granuloma formation is accompanied by dramatic remodeling of host vasculature which ultimately benefits the infecting mycobacteria, suggesting the …
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CRISPR-integrated Biosensors for Human Health: Novel strategies for pathogen detection and cancer screening
… O157:H7 serotype markers, validated in a mouse infection model. Finally, the sensitivity of the CRISPR/Cas12a system was enhanced through site-specific covalent crosslinking between Cas12a and crRNA, which improved detection of SARS-CoV-2 in clinical samples. Together, these studies demonstrate …
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Characterization of Deoxycholate-Responsive Genes Utilized by Brucella abortus 2308 During Oral Infection
… hepatosplenomegaly and endocarditis. Brucella infection is most often acquired via inhalation through the respiratory route, or via consumption of unpasteurized dairy products. Although ingestion is a major route of infection, the transcriptional response of B. abortus during oral infection …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… shrinking treatment options for life-threatening infections. Among the most concerning pathogens are vancomycin-resistant Enterococcus (VRE), which causes serious bloodstream, urinary tract, and wound infections, particularly in hospitalized patients. This thesis explores two complementary …
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