Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"infection dynamics"”.
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Senecavirus A: Epidemiology, Pathogenesis and Infection Dynamics
… in the field. Many aspects of SVA epidemiology, infection biology, and pathogenesis, remain unknown. Also, the cause(s) for the recent emergence of SVA in swine remains unknown. The objectives of our study were – 1) To investigate epidemiological factors that may contribute to SVA spread in the …
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Microbiota-host interactions and infection dynamics in critical illness.
… in the ICU experience high rates of secondary infections, largely attributed to immune dysfunction and impaired host defense. We recently reported that intestinal dysbiosis in critically ill patients is associated with expansion of hypofunctional immature neutrophils, resulting in a significant …
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Characterization of rickettsial infection dynamics within Dermacentor variabilis and Amblyomma maculatum
… an in vitro and in vivo model of R. parkeri infection was utilized. Rickettsial proteins implicated in intracellular actin-based motility (Sca2 and RickA) were shown to function similarly in mammalian and tick cell culture, suggesting conserved functionality in both hosts. In vivo …
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Host and Seasonal Effects on the Infection Dynamics of Skrjabinoptera Phrynosoma (Ortlepp) Schulz, 1927, a Parasitic Nematode of Horned Lizards
… of season as well as host characteristics on the infection dynamics in lizard hosts. In the Alvord Basin in southeastern Oregon, S. phrynosoma were collected from Phrynosoma platyrhinos Gerard 1852 horned lizards via stomach flushes, cloaca flushes and fecal pellet collections. Parasite load …
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A discrete-time waning immunity model for the spread of an immune escape pathogen
… large amplitudes of damped oscillations in infections. The classic Susceptible-Infectious-Immune-Susceptible (SIRS) model is a waning immunity model but is unable to generate rapid high amplitude oscillations. The oscillatory dynamics generated by SIRS-like models are often boosted by …
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Bovine Coccidiosis: Dynamics of infection in grazing cattle and the potential role of stress and immunity
… infect cattle worldwide. Information on the infection dynamics of these parasites is lacking in the central Appalachian region of the United States. Studies aimed at characterizing the seasonal dynamics of eimerian parasites in this region were carried out in order to assess the impact of …
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Linking mosquito midgut and virus population biology at the molecular and cellular level
… pathogen transmission by vectors. Each step in infection of a mosquito vector constitutes a barrier to transmission that may impose bottlenecks on virus populations. West Nile virus (WNV) is maintained by multiple mosquito species with varying VC. However, the extent that bottlenecks and VC are …
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Spatial and temporal distribution of a marine microbial parasite, Syndiniales MALV I and II, within St Helena Bay
… These organisms play an important role in bloom dynamics, are suspected to terminate algal blooms, and contribute significantly to carbon fluxes, an important process required to lock away greenhouse gases. The study aims to investigate the spatial and temporal distribution of MALV I and II and …
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The Distribution and Biology of the Invasive Eyefluke of Waterfowl (Philophthalmus gralli) in Texas
… in Texas, and to experimentally investigate the infection dynamics of the parasite to better understand its ecology. First, I investigated the current geographic distribution and infection status of the parasite in the eyes 1,362 hunter-harvested waterfowl wintering in Texas during the fall 2016 …
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From traffic to transmission: adapting an agent-based transport model to simulate the spreading of infectious diseases
… includes a synthetic population and potential infection pathways. Building on this foundation, the thesis presents a model that integrates the approaches from transport modeling with a mechanistic infection model and a disease progression model to simulate the spreading of infectious diseases. …
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Supply chain coordination and influenza vaccination
… health benefits of vaccination that are due to infection dynamics) and vaccine production yield issues. In this thesis we present two models in the interface of operations and supply chain management and public health policy. In the first model, we focus on a supply chain with a government and a …
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Quantifying Metagonimoides oregonensis infection distribution and effects among stream salamander hosts
… five of the six species examined had natural infections, but that there was variation in infection intensity and prevalence among the species. Of the six species, Desmognathus quadramaculatus may be most important in transmission, as they had the highest prevalence and intensity of infection. …
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Estimating network structure and propagation dynamics for an infectious disease : towards effective vaccine allocation
… contact network and of the propagation dynamics. In this thesis we develop a parameter estimation method that learns the network structure, among a family of graphs, and disease dynamics from the recorded infection curve, assuming that the disease dynamics follow an SIR process. We apply …
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Interactions Between the Odorous House Ant (Tapinoma sessile) and RNA Viruses: a Multi-Faceted Approach
… how colony social organization influences viral infection patterns. Inoculation experiments confirmed active infection in T. sessile colonies, suggesting trophallaxis as a route for horizontal transmission. These viruses were prevalent in urban populations with polygyne, unicolonial traits, …
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Evaluating Campylobacter spp at the human-wildlife interface
Campylobacter spp. infections are an increasing global concern responsible for a significant burden of disease every year. Wildlife and domestic animals are considered important reservoirs, but little is known about host-factors driving pathogen infection dynamics in wild mammal populations. In …
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Decision Making for Populations
… and enable in-silico forecasting of infection dynamics by merging simulators with deep neural networks. Second, we introduce Adaptive Split Learning (AdaSplit) a mechanism for distributed & privacy-aware machine learning in low-resource setups. AdaSplit achieves state-of-the-art …
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The Consequences of Plant Anatomy on Viral Co-Infection
… work aims to identify opportunities during host infection for viral populations to interact, so that it can be determined where genetic exchange events occur in the future. I investigated the viral population dynamics of tobacco etch virus (TEV, genus Potyvirus) within the plant host Nicotiana …
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Investigating virus-host interactions in a changing Arctic Ocean
… and freshening affecting microbial community dynamics, including primary productivity. In the Arctic, primary production is driven by eukaryotic phytoplankton and one picoeukaryote in particular, Micromonas polaris, is ecologically dominant. Basic knowledge of the spatial variability and …
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Age-Dependent Variability in Immune Host Responses to SARS-CoV-2: Implications for Inclusive Clinical Trial Design
… the effects of IFNβ pre-treatment on SARS-CoV-2 infection dynamics in lung epithelial cell models. We identified interferon-stimulated gene signatures associated with antiviral protection, and found that pre-activation of the IFN pathway significantly reduced viral replication and dampened …
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Impact of climate- and urbanization-driven environmental change on Aedes aegypti susceptibility to Zika virus
… little is known about how it affects mosquito infection dynamics. Survival under desiccation stress is correlated with ZIKV infection rates in genetically diverse lines of Ae. aegypti originating from Senegal. Here, we investigated the genetic relationship between desiccation tolerance and ZIKV …
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