Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"infarct volume"”.
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Effect of Rat Strain Stereotactic Coordinates on Infarct Volume
… Long Evans rats sustain a significantly larger infarct volume compared to Sprague Dawley rats using Group 2 coordinates; Group 1 cortical injection coordinates produced a larger infarct than Group 2 coordinates in FSA Sprague Dawley rats; drug treatment showed no effect on total infarct volume, …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… factors of ischemic stroke outcome measured by infarct volume. This model is the middle cerebral artery occlusion (MCAO) model. First, we screened infarct volumes across 32 inbred mouse strains. The infarct volume varies between strains, and this strongly suggests that infarct volume is …
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Comparison of transplantation modality of human mesenchymal stem cells expressing neurogenin1 in rat middle cerebral artery occlusion model: intra-arterial vs. intra-cerebral
… oxide (SPIO) labeling, and the serial changes of infarct volume in brain magnetic resonance image (MRI). MRI analysis with the SPIO-labeled cells indicated more even distribution in the animals with IA-MSCs/Ngn1 than the one with IC-MSCs/Ngn1. The animals with IA-MSCs/Ngn1 showed significantly …
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Unraveling the Role of EphA4 in Immune-Mediated Arteriogenesis After Ischemic Stroke
… We assessed immune cell population changes, infarct volume, functional recovery, characterized subtypes of infiltrated immune cell, and measured collateral vessel diameters. Additionally, we explored the Tie2-mediated PI3K signaling pathway in peripheral-derived monocyte/macrophages (PDM) …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or post-treatment (i.c.v. and i.p.) in a middle cerebral artery occlusion model in mice and decreased neurological deficits induced by ischemia. The protection of HNG was mediated …
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Gelatin nanoparticles for improved neuroprotection of intranasally delivered osteopontin in ischemic stroke
… reperfusion without further mechanisms to reduce infarct volume or promote healing and are most effective within 3 h of symptom onset: a window in which less than 30% of stroke victims receive medical attention. Osteopontin (OPN), a ubiquitous protein with roles in cell migration, inflammation, …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… both G-CSF and metyrapone significantly reduced infarct volume via anti-apoptotic properties but lost its protective effect when combined with dexamethasone. Additionally, G-CSF suppressed the increase of corticosterone in the blood after HI. To investigate the mechanism by which G-CSF modulated …
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Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… both G-CSF and metyrapone significantly reduced infarct volume via anti-apoptotic properties but lost its protective effect when combined with dexamethasone. Additionally, G-CSF suppressed the increase of corticosterone in the blood after HI. To investigate the mechanism by which G-CSF modulated …
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Pathophysiological role of aldosterone in cardiac remodelling after myocardial infarction
Acute myocardial infarction (AMI) remains a common and serious manifestation of coronary artery disease. The development of heart failure (HF) and/or evidence of left ventricular systolic dysfunction (LVSD) following AMI increases both in-hospital and longer-term mortality. A series of structural …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
… (BBB), ameliorating brain edema, and reducing infarct volume via VEGF-dependent pathway. We also investigated if matrix metalloproteinases (MMPs), one of HIF-1 downstream factors, are involved in the process of neonatal HI brain injury. We hypothesized that broad-spectrum MMPs inhibition …
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The Role of Wnt3a in Ischemic Stroke
… neuroprotective agent wnt3a would reduce infarction and improve behavior following ischemic stroke by attenuating neuronal apoptosis and promoting cell survival through the Frizzled-1/PIWI1a/FOXM1 pathway in MCAO rats. 229 Sprague-Dawley rats were assigned to male, female, and aged 9-month …
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Effect of head elevation on intracranial blood flow velocity following acute ischemic stroke
… brain tissue that may ultimately reduce brain infarct volume.
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Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… reperfusion without further mechanisms to reduce infarct volume or promote healing and are most effective within 3 h of symptom onset: a window in which less than 30% of stroke victims receive medical attention. Numerous neuroprotective agents, such as peptides, hormones, and siRNA, have been …
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Developing an adjunct therapy to mechanical thrombectomy in a murine model of stroke ischaemia reperfusion injury
… However, despite these improvements, brain infarction and damage following MT are exacerbated by ischaemia-reperfusion (IR) injury during reperfusion of the ischaemic tissue. Therefore, an adjunct therapy to MT that decreases IR injury should enhance patient outcomes. One of the main drivers …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… to neuronal cell death and the development of an infarct. The infarct region is divided into two parts: 1) A central part or an ischemic core, where the neurons die and have no chance to survive without rapid reperfusion. 2) A peripheral area or an ischemic penumbra, which surrounds the core [12]. …