Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"infarct size"”.
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Infarct size and free fatty acids in the early phase of acute myocardial infarction
The management of acute myocardial infarction (AMI) has been improved by the realisation that the size of infarction can influence mortality (Sobel et al, 1972) and that the infarct size can be altered by subsequent therapy (Maroko et al, 1972). The identification of any factor which may have …
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Acute Myocardial Infarction: The Relationship between Duration of Ischaemia and Infarct Size in Humans - Assessment by MRI and SPECT
The effect of duration of ischaemia on final infarct size is well established in animal studies, but not fully evaluated in humans. Delayed contrast-enhanced magnetic resonance imaging (DE-MRI) can be used to distinguish between viable and non-viable myocardium and thus to quantify infarct size. We …
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Hypothermia as an adjunctive therapy in Acute Myocardial Infarction and Cardiogenic Shock
… patients with an ongoing ST-elevation myocardial infarction (STEMI) is to re-establish coronary flow in the epicardial arteries as soon as possible in order to reduce infarct size and associated complications. Hypothermia has in experimental studies been shown to reduce infarct size. Clinical …
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Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences.
… knockout and HFD intervention on the myocardial infarct size sustained following a period of ischaemia/reperfusion (I/R) and 3) make use of an in vitro model to elucidate the mechanisms by which changes occur in the adipose tissue of mice fed a HFD. GPR55-/- mice fed a HFD for 12-weeks gained …
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Quantitative assessment of myocardial infarction: On the relationship between anatomy and electrophysiology using MRI and ECG
Both presence and extent of myocardial infarction are important prognostic factors for mortality and quality of life in patients with ischemic heart disease. Thus, it is of great clinical importance to be able to diagnose and characterize myocardial infarction. One way to diagnose myocardial …
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Quantitative and Qualitative Assessment of the Myocardium at Risk
One of the major determinants of the final infarct size during an acute coronary occlusion is the size of the myocardium subjected to ischemia. Identification and quantification of this so-called myocardium at risk in the acute phase of ischemia has been difficult in patients with conventional …
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Dysfunctional but viable myocardium - ischemic heart disease assessed by magnetic resonance imaging and single photon emission computed tomography
… that wall thickening decreases with increasing infarct transmurality. However, the variation in wall thickening was large, and importantly, influenced more so by the function of adjacent myocardium than by infarct transmurality. This underscores the difficulty of using resting function alone to …
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Cardioprotective treatment strategies
… porcine ischemia/reperfusion model was used. Infarct size (IS), microvascular obstruction and area at risk (AAR) were measured with ex-vivo MRI and SPECT. ADC-1004 treatment (paper I) was found to reduce infarct size (ADC-1004: 58.3±3.4 vs control: 74.1±2.9 %AAR, p=0.007) but not microvascular …
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Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /
… intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute myocardial infarction (AMI), when PCI and stenting were used …
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Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
… permanent coronary ligation to induce myocardial infarction (MI). mPer2-M mice had a 43% smaller infarct size compared to wild type (WT), along with reduced leukocyte infiltration, increased capillary density, increased myocyte hypertrophy, and reduced myocyte apoptosis. This suggests that …
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Coronary Reactive Hyperemia
… an increased release of t-PA. It was also hypothesized that hypothermia may have effects on coronary reactive hyperemia and that rapidly induced hypothermia prior to reperfusion in an infarction model could reduce myocardial infarct size. Material and Methods: All studies were performed in a …
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Assessment of myocardial viability using magnetic resonance imaging
Myocardial infarction (MI) following an acute coronary occlusion is a leading cause of morbidity and mortality. During revascularization, microemboli may complicate treatment and affect cardiac function. The long-term effects of microembolization are not fully elucidated. Following an MI it is …
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Long-term cardioprotection with phosphodiesterase-5 inhibition against ischemia-reperfusion injury: Role of nitric oxide.
… I/R. The results show significant reductions in infarct size in hearts treated with sildenafil and vardenafil as compared to the corresponding saline controls at all time points. The protective effects of sildenafil and vardenafil were abrogated in animals treated with L-NAME. L-NAME had no …
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The safety and efficacy of novel dual function coronary stent in porcine model of myocardial infarction
… injured myocardium following acute myocardial infarction in pigs. Background: For more than a decade, drug eluting stents have written a successful chapter in coronary revascularisation following myocardial infarction. However, none so far has further exploited these stents beyond their primary …
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The role of melatonin in red wine-induced cardioprotection
… heart failure. Functional parameters and infarct size were assessed. The chronic moderate consumption of red wine for 14 days reduced infarct size from 60±2.3% to 23.3±1.8% after ischemia reperfusion injury, p<0.001. The pretreatment with melatonin protected to a similar extent as red wine …
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The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… during I/R are unknown. Therefore, we hypothesized that S1P-induced cardioprotection is mediated by modulation of the glycocalyx during I/R in the isolated rat heart. Methods: Isolated male Wistar hearts were perfused on a Langendorff system with Krebs-Henseleit buffer via retrograde perfusion …
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Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia.
… with symptoms compatible with acute myocardial infarction (MI), early triage by ECG in the pre-hospital phase by ST-segment elevation myocardial infarction (STEMI) criteria is important for direct transport of these patients to a regional center for primary percutaneous coronary intervention …
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Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
… cardioprotective signaling pathway. We hypothesized that upregulation of Akt occurs possibly as part of a positive feedback mechanism following the inhibition of mTOR by rapamycin. Adult male ICRmice were treated with rapamycin (0.25 mg/kg, i.p.), or volume-matched DMSO (solvent for rapamycin), …
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NOVEL STRATEGIES TO IMPROVE METABOLIC PARAMETERS AND PRECONDITION DIABETIC HEARTS AGAINST ISCHEMIA/REPERFUSION INJURY
… of miR-103/107 is caveolin-1 (Cav-1). We hypothesized that daily administration of the phosphodiesterase-5 inhibitor tadalafil (TAD) ± the curcumin analogue (HO-3867) will attenuate inflammation, improve metabolic parameters and reduce infarct size after ischemia/reperfusion injury (IRI). …
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Prenatal Cocaine Exposure and Cardiac Programming
… juvenile and adult rats by increasing myocardial infarct size and decreasing postischemic recovery of left ventricular function. Interestingly, the effect of prenatal cocaine exposure on cardiac vulnerability in adult offspring is gender-dependent, with the male heart being more susceptible to …
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