Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"induction of tolerance"”.
-
Regulatory mechanisms in transplantation tolerance: the induction of tolerance by adoptive transfer in MHC-inbred miniature swine
Organ transplantation has been the standard of care for end-stage organ failure. While one-year renal allograft survival has increased to over 90% in the past couple of decades with the use of new immunosuppressants, the long term survival of kidney allografts have remained the same due to …
-
Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… Membranous nephropathy (MN) is a common cause of nephrotic syndrome in humans, and many patients progress to end-stage kidney disease. The best available animal model of MN is active Heymann nephritis (HN) in which rats are immunized with renal tubular antigen (RTA) in complete Freund's …
-
Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
… been used as a powerful tool for the treatment of experimental asthmatic responses. We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA approach to silence IL-10 gene expression in murine DC10 …
-
Effect of tolerogenic peptide administration on pathogenic antigen-experienced T cells
The administration of soluble antigenic peptides is known to be effective at inducing tolerance in naïve antigen-reactive CD4+ T cells. This observation forms the basis of antigen-based therapy, which offers the potential to specifically target the auto-reactive CD4+ T cells involved in driving …
-
Nrf2 in metabolic related inflammation in the brain
… and oxidative stress (OS). Disruption of NF-E2-related factor 2 (Nrf2) signalling increases OS and promotes AD. Amyloid precursor protein (APP) is intimately linked with AD, with the Swedish mutation (<i>hAPP<sub>swe</sub></i>) used in numerous transgenic models. Furthermore, increasing …
-
Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… inflammation-induced injury are 1.) the presence of immunosuppressive molecules within the aqueous humor; 2.) the expression of pro-apoptotic factors on corneal cells ; and 3.) the induction of a form of immune tolerance called anterior chamber-associated immune deviation (ACAID). Immune privilege …
-
IDENTIFICATION AND CHARACTERIZATION OF THE 'GUT VASCULAR BARRIER'
In order to protect the body from a wide range of harmful environmental agents, the intestine has developed a number of barrier mechanisms to limit the entry of potential hazards. These include the physical barrier formed by the epithelial layer and the intestinal immune system that is important to …
-
Durchflußzytometrische Analysen zur spenderspezifischen Toleranzinduktion nach kombinierter orthotoper Leber/Dünndarmtransplantation
Trotz der Entwicklung neuer und selektiver Immunsuppressiva, bleibt die Transplantation des Dünndarms auch weiterhin bei einer Fünfjahresüberlebensrate von 35% ein risikoreiches Verfahren, welches nur bei einem kleinen Patientenspektrum derzeit indiziert ist. Die Erkenntnis, daß eine …
-
Compartmental responses of the respiratory tract to Staphylococcus aureus
… pathogen is a risk factor for the development of subsequent infection. Tolllike receptors (TLRs) are a family of transmembrane receptors of the innate immune system that recognize pathogen-associated molecular patterns. The role of nasal colonisation of S. aureus has started to receive more …