Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"induced-cellular senescence"”.
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Reduction of tumorigenesis in androgen receptor overexpressed Huh7 cells through TGF-β induced cellular senescence phenotypes
PURPOSE: Hepatocellular carcinoma (HCC) is a primary malignancy (cancer) of the liver. HCC has been known as androgen-dependent tumor with incidence of five times higher and worse prognosis in male than female. Steroid hormones and their receptors play a major role in the development of many types …
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Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
… A low level of oncogenic Ras signaling induced cellular hyperproliferation, whereas a high level of signaling induced cellular senescence. A growing body of literature links loss of p38 mitogen-activated protein kinase (MAPK) activity with the promotion of Ras-induced transformation in …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… plays essential roles in controlling normal cellular functions as well as abnormal cellular activities in human diseases like inflammatory diseases and cancers. The bromodomain-containing protein 4 (BRD4), one of the BET (bromodomain and extra terminal) family proteins, represents a class of …
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Induction of Cellular Induction Senescence by BTG2_(TIS21/PC3) Gene in Huh7 Hepatocellular carcinoma Cells
… cycle regulator and an important factor for cellular senescence. However, there has been no experimental evidence to confirm TIS21 as a regulator of cellular senescence. In this study, we observed the changes of TIS21 expression in the replicative senescence of human diploid fibroblast (HDF) …
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Studien zur Regulation der Clusterin-Expression in der MCF-7- und MDA-MB-231-Mamma-Karzinom-Zelllinie
… of TSA on the induction of p21 expression, cellular senescence and cell survival, all processes known to be influenced by cytostatic agents and apoptosis inducing drugs. mRNA and protein expression were examined by real-time RT-PCR, Western Blot analyses and immunohistochemistry in …