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Showing 1 to 20 of 21 for “"indoleamine 2,3-dioxygenase"”.
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Structure guided discovery of inhibitors of indoleamine 2,3-dioxygenase (IDO1)
The enzyme indoleamine 2,3‐dioxygenase‐1 (IDO1) plays a critical role in the regulation of the immune system. IDO1 expression is commonly upregulated in cancer, resulting in a suppressed immune system in patients. Clinical observations that patients with high IDO1‐expressing tumours have a poor …
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Design and Synthesis of Hydroxylamine Derivatives as Indoleamine - 2,3 - Dioxygenase Inhibitors
<p>Current research describing therole of indoleamine 2,3-dioxygenase (IDO) and its mechanism of action suggests that the inhibition of IDO with small molecule inhibitors, especially in conjunction with chemotherapy, can provide an effective and novel cancer treatment strategy. This inspired our …
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… like behavior. The tryptophan degrading enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has also been implicated in neurodegenerative disease and depression. IDO1 activity increases kynurenine concentrations in circulation and brain tissue following LPS administration. Further, IDO1 has been shown …
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Investigating the Role of Indoleamine 2,3-Dioxygenase 1 and Transforming Growth Factor Beta 1 in Rebound Immune Suppression Following Chemotherapy in Osteosarcoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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The identification and characterization of novel persistence genes in chlamydia trachomatis
… IFN-γ stimulates expression of the host enzyme indoleamine 2,3-dioxygenase. This enzyme converts free intracellular tryptophan to N-formylkynurenine. Tryptophan starvation induces C. trachomatis to enter a viable-but-nonculturable state termed persistence, which has been proposed to play a key …
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Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… We have also demonstrated that the enzyme Indoleamine-2,3- dioxygenase is upregulated in active disease thus providing a possible explanation for the increased burden of psychological disease encountered in CSX. Analysis of the microRNA transcriptome showed that miR-143 is significantly …
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Characterization and Immunomodulatory Function of Human Mesencymal Stem Cells
… 관여한다는 사실을 알 수 있었다. 중간엽줄기세포에서 IFN-γ에 의해 발현되는 IDO(indoleamine 2,3-dioxygenase)는 T 세포 증식에 필수적인 tryptophan을 분해하여 면역 억제를 유도한다. 면역세포 증식 실험시 anti-IFN-γ를 처리하거나, tryptophan을 첨가하여 면역세포의 증식이 회복되는 결과를 통해서 중간엽줄기세포의 T 세포 증식억제에 IFN-γ와 IDO가 관여한다는 사실을 증명하였다. 또한 중간엽줄기세포에 IFN-γ를 처리하였을 때 세포내 신호전달물질을 확인한 결과 STAT1과 …
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The involvement of the kynurenine pathway in the pathogenesis of multiple sclerosis
… the involvement of the KP in neuroinflammation [Indoleamine 2,3-dioxygenase (IDO-1) expression and its immune regulatory role] and neurodegeneration (balance between neuroprotective and neurotoxic KP metabolites). The main findings of this project are: (1) the KP metabolism is altered in MS …
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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… analysis revealed that a L. major-induced Indoleamine 2,3 dioxygenase (IDO)-mechanism could allow for increased Leishmania replication. Collectively, these data suggest a protective role for IL-4Rα signalling on Treg cells in suppressing a detrimental Type 2 during cutaneous leishmaniasis.
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Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
… and down-regulation of arginase-1 and indoleamine 2,3-dioxygenase (IDO) expression. Of therapeutic relevance, the frequency of effector lymphocytes (CD4⁺ and CD8⁺ T cells) or natural killer cells (NK) to suppressive MDSC ratios was significantly increased following doxorubicin treatment …
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A microparticle engineering approach to enhance the potency of mesenchymal stem cells
… potency of MSCs by up-regulating expression of indoleamine-2,3- dioxygenase (IDO) is reported. Loading MSCs with particles containing the glucocorticoid steroid, budesonide, doubled their potency in suppressing activated peripheral blood mononuclear cell co-cultures in an IDO dependent manner. …
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Combination of Oncolytic Adenoviruses, T-Cell Activation, and Blockade of Ido Metabolic Circuitry For The Treatment of Glioma
… within the glioma microenvironment. For example, indoleamine-2,3-dioxygenase (IDO) is upregulated in glioblastoma, correlates with poor prognoses, and is a main source of immunosuppression. IDO is an IFN inducible enzyme that catabolizes tryptophan resulting in diminished proliferation or …
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Effects of voluntary wheel running and forced treadmill running on inflammation induced behavioral abnormalities in young and old mice
… or whole brain proinflammatory cytokine and indoleamine 2,3-dioxygenase gene expression in young adult and aged mice. Forced treadmill running following BCG inoculation caused protracted recovery from infection as evidenced by prolonged body weight loss, reduced voluntary wheel running, and a …
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Understanding factors that affect gene co-regulation patterns
… disorders, being tryptophan-degrading enzyme Indoleamine 2,3-dioxygenase (IDO1) activated during the inflammatory process. The goal of this study was to understand pathways associated with depression-like symptoms after recovery from immune challenge and deficiency of a gene associated with …
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Investigação de parâmetros bioquímicos em dois modelos animais de depressão induzidos por desamparo aprendido e administração do lipopolissacarideo de E.Coli
… and depressive-like behavior on hippocampus. Indoleamine 2,3-dioxygenase (IDO) enzyme activity was not altered on learned helplessness model. Systemic administration of LPS (0,8 mg/kg) induced sickness behavior on animals characterized by decreased food and water intake, bodyweight loss and …
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The Immunology of Adeno-Associated Virus Serotype 2
… protocol, utilising a plasmid encoding indoleamine 2,3-dioxygenase (IDO), was instead adopted. Transfection was successful, MSC morphology was not altered and osteogenic and adipogenic functions remained. However, MSC cell numbers in culture declined sharply in the 24 hours following …
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Biochemical aspects of Tourette's Syndrome
… In the liver, cortisol-inducible tIyptophan-2,3-dioxygenase (TDO) is the first enzyme and rate limiting step. In extrahepatic tissues, it is superceded by indoleamine-2,3-dioxygenase (IDO), an enzyme with a wider substrate specificity. Earlier work in this research group has found substantial …
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… 17 (Th17) cells, induction of the enzyme indoleamine 2,3-dioxygenase (IDO) and regulation of monocyte function during pregnancy. In addition, kisspeptin has been implicated in the regulation of specific cytokines during pregnancy. It is crucial to maintain an appropriate cytokine balance …
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Neural and Behavioural Consequences of Chronic Inflammation following Spinal Cord Injury
… have been shown to up-regulate the enzyme indoleamine 2,3 dioxygenase (IDO) resulting in the accelerated degredation of serotonin precursor tryptophan (TRP) and increased production of TRP metabolites such as kynurenine (KYN). They have also been shown to upregulate the enzyme …
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