Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"indole-3-carbinol"”.
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Novel studies of fat and nutrient intakes and the risk of human cancers
… In the second study, a urinary biomarker of indole-3-carbinol exposure from cruciferous vegetable intake was validated in a crossover feeding study. Finally, the associations between dietary fish, fat, and antioxidant intakes and the risk of gastric cancer were evaluated in the large …
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The Effects of Immunomodulatory Agents On the Development of Experimental Autoimmune Encephalomyelitis
… able to show for the first time that dietary indoles, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) can dramatically inhibit the development of EAE as demonstrated by reduced clinical scores and maintenance of architecture of spinal cord histopathology. These dietary indoles …
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Effect of broccoli bioactives on prostate cancer cell invasion in vitro
… cells were treated with sulforaphane (SF), indole-3-carbinol (I3C), hydrolyzed neoglucobrassicin (hNGB), and quercetin (Q) individually or in selected combinations. After a total of 48 hour treatment exposure, with the treatments being renewed at the 24th hour, the invading cells were fixed, …
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Molecular Definition of Cytochrome P450 -Mediated Multiple Resistance in Helicoverpa Zea
… plant defense end products xanthotoxin, idole-3-carbinol, chlorogenic acid, and flavone, and by a synthetic chemical not naturally encountered, phenobarbital. Molecular modeling indicated that CYP6B8, representative of the four H. zea CYP6B proteins has more flexible overall folding, a larger and …
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The role of foliar glucosinolates in host plant resistance of oilseed rape and mustard to the Bertha armyworm and the diamondback moth
… manner. No effects were observed with indole-3-carbinol, the metabolite of 3-indolylmethyl glucosinolate. Foliar isothiocyanate-releasing glucosinolates may provide some protection against polyphagous insects. Plant growth stage differences in the relative resistance of brassicaceous …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… (TCDD), and natural sources, such as indole-3-carbinol (I3C) and indirubin. Crohn's disease, a chronic inflammatory state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… (TCDD), and natural sources, such as indole-3-carbinol (I3C) and indirubin. Crohn's disease, a chronic inflammatory state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the disease. The role of the AhR in …
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
… with the glucosinolate breakdown product indole-3-carbinol (I3C) has been shown to increase formation of 2-hydroxyestrogens, estrogen metabolites with weak estrogenic activity. However, the observed reduction in risk for estrogen-associated cancers with increased consumption of cruciferous …
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Toxicity of mycotoxins to insects and underlying molecular and biochemical mechanisms
… of induced midgut enzymes (coumarin>xanthotoxin>indole 3-carbinol). These results indicate that induction of P450s, such as CYP321A1, plays an important role in reducing AFB1 toxicity to H. zea. Docking of AFB1 in the molecular models of CYP321A1 and CYP6B8 highlights differences in their …