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Showing 1 to 20 of 324 for “"indole"”.
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Modifying Tryptophan and Indole-Derived Compounds Using Engineered Indole Prenyltransferase Enzymes
<p>Indole Prenyltransferase (IPT) enzymes are present in many microorganisms. They catalyze the transfer of prenyl moieties from natural pyrophosphate donors to tryptophan and other indole-derived small molecules. Prenylation alters the structure of small molecules, enhances their hydrophobicity, …
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High level indole signalling in Escherichia coli
Indole is a small signalling molecule, produced by many species of bacteria, including Escherichia coli. It is made by the enzyme tryptophanase, which converts tryptophan into indole, pyruvate and ammonia. Indole has diverse roles in E. coli, including regulation of biofilm formation, acid …
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A general entry to C7-borono indole derivatives
… to access C7 pinacolatoboron substituted indole derivatives is described. It has been applied to indole, tryptophan, and tryptamine derivatives. Further functionalization to a C7 phenolic tryptamine derivative is also described.
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Tryptophan and indole accumulation by Escherichia coli mutants
Thesis: Sc. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1964
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Derivation and chromatographic separation of acid indole auxins
… analysis. The three phytochemically significant indole acids; 3-indole acetic acid, 3-indole propionic acid, and 3-indole butyric acid along with an analog, D-tryptophan, are four compounds which have been analyzed by this method. A detailed study of the trimethylsilylation reaction of these …
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Asymmetric Total Synthesis of the Pentacyclic Indole Alkaloid (+)-Tacamonine
… new tacaman class of pentacyclic monoterpenoid indole alkaloids. Its close structural similarity to the potent cerebral vasodilator (-)-vincamone has promoted several efforts towards its synthesis, culminating in the appearance of two asymmetric and seven racemic syntheses in the literature. …
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Studies on the Catalytic Hydrogenation of Some Indole Compounds
Made available in DSpace on 2014-12-09T17:35:16Z (GMT). No. of bitstreams: 1 6507181.pdf: 3024097 bytes, checksum: 805d3db92f18b15ffcb34be009f39e62 (MD5) Previous issue date: 1965
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Natural and synthetic bis-indole alkaloids as cytotoxic agents
… and purified and it proved to be a new bis-indole alkaloid. It was given the name tabernamine and showed an activity of 1.9 μg/ml (ED₅₀) in the PS in vitro system and a T/C % of 125 at a dose of 25 mg/kg in the PS in vivo system. In conjunction with these results and the knowledge of the …
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Phytochemical Investigations of Fungi: Hydrogen-Cyanide, Indole Alkaloids and Carbohydrates
… metabolites including hydrogen cyanide, indole alkaloids and reserve carbohydrates were investigated. The major emphasis of this study concerned the taxonomic significance and the mechanism of HCN production by microorganisms, especially fungi.
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Chemistry of Indole Compounds Containing the Beta-(2-Nitroalkyl) Group
Made available in DSpace on 2014-12-05T19:37:49Z (GMT). No. of bitstreams: 1 6104409.pdf: 4062721 bytes, checksum: 059d28e30e8b80ff853eed7a99ae2419 (MD5) Previous issue date: 1961
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Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
… compounds with diverse biological activity. The indole nucleus for instance, is an important element of many natural and synthetic molecules with significant biological activity. Drug discovery and development processes highly value the utility of the ability to synthesize a diverse library based …
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Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development
<p>Prenyltransferase (PT) biocatalysts are late-stage tailoring enzymes that modify natural products. PTs catalyze the attachment of prenyl moieties to natural product acceptors using pyrophosphate donors. This prenyl modification in small molecules leads to changes in structural and biological …
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Influence of Indole and Mixed Culture Growth on Pseudomonas Aeruginosa Biofilm Structure
… that E. coli production of the organic compound, indole, inhibited AHL-regulated genes in P. aeruginosa. The current study was conducted to see if mixed culture growth of P. aeruginosa with indole-producing E. coli affected biofilm structure. Two wt Pseudomonas aeruginosa strains, PA14 and PAO1 …
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Localization of monoterpenoid indole alkaloid (MIA) biosynthesis by in situ hybridization (ISH)
Monoterpenoid indole alkaloids (MIA) are among the largest and most complex group of nitrogen containing secondary metabolites that are characteristic of the Apocynaceae plant family including the most notable Catharanthus roseus. These compounds have demonstrated activity as successful drugs for …
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Functional Characterization of Monoterpenoid Indole Alkaloid (MIA) Biosynthetic Genes in Catharanthus roseus
The monoterpenoid indole alkaloids (MIAs) of Madagascar periwinkle (Catharanthus roseus) are known to be among the most important source of natural drugs used in various cancer chemotherapies. MIAs are derived by combining the iridoid secologanin with tryptamine to form the central precursor …
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