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Showing 1 to 1 of 1 for “"indenoisoquinoline"”.
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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL INDENOISOQUINOLINES AS POTENTIAL ANTICANCER AGENTS
… design, synthesis, and biological evaluation of indenoisoquinolines that inhibit the human topoisomerase IB enzyme (Top1). At present, there are only two FDA-approved cancer chemotherapeutic drugs that target this enzyme. These agents bind to a covalent Top1-DNA cleavage complex intermediate that …