Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"indazole"”.
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The synthesis of novel indazole alkaloids with potential medicinal properties.
… 7a-d were prepared for cyclisation into indazoles 8a-d. Reaction of phenylhydrazine with benzoyl chloride, 4-benzyloxy benzoyl chloride and 4-nitrobenzoyl chloride gave hydrazides 7a-c whilst reaction of and 2-ethylphenyl hydrazine with 4-nitrobenzoyl chloride produced 7d. All the four …
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Advances in the synthesis of indazoles: regioselective C-7 functionalization by directed ortho metalation and progress towards indazole based azaborine compounds
… of the fundamental heterocyclic building blocks, indazole and its derivatives have spurred significant research interest and patented applications. In particular, C-7 substituted indazole derivatives are of prime interest due to their significant bioactivities. Azaborine molecules incorporating …
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Studies in the synthesis and analysis of novel heterocyclic synthetic cannabinoid receptor agonists
… heterocyclic building block in the synthesis of indazole-type SCRA ligands, 1H indazole-3-carboxylic acid, this work describes the development and application of a protocol for the regioselective (>99%) N-1 alkylation of the indazole scaffold to generate a wide range of structurally diverse N-1 …
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ADVANCES IN THE DIRECTED ORTHO METALATION, SUZUKI-MIYAURA CROSS COUPLING, AND RING-OPENING REACTIONS OF INDAZOLES. SYNTHESIS OF LUMINESCENT ACRIDINE AND NOVEL INDAZOLE-BASED OXAZABORINES
… for the carbon and nitrogen functionalization of indazoles and the reactivity challenges faced therein. This is followed by a comprehensive review of current C-7 substitution strategies and their limitations. It then describes our developments in the regioselective C-7 functionalization of N-1 …
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Studies on a catalytic cadogan cyclization by PI̳I̳I̳/PV̳=O redox cycling
… found to successfully undergo catalytic Cadogan indazole cyclization. The mechanism of the cyclization has been expanded. The resting state of phosphorus was determined to be the P" phosphetane, and this phosphetane proved to be 8 times faster than the acyclic n-Bu₃P at driving the reductive …
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Kinetic studies of the hydrolysis reactions of ruthenium (III) complexes hIm trans-[RuCl₄(im)₂] and hInd trans-[RUCl₄(ind)₂] by uv-visible spectrophotometry
… of the ruthenium complexes. Imidazole and Indazole are the two ligands used for this study. We found that the hydrolysis reaction of the Ruthenium-Imidazole (RIM) complex is a two-step process that involved the formation of an intermediate. The rate constants for the two steps in the …
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Structure Based Drug Design of High Affinity Kras Inhibitors
… based molecule compound 11 and (ii) a indazole based molecule compound M1. Compound 11 exhibited a monotonous dose-dependent inhibition of KRAS signaling, however compound M1 demonstrated a biphasic dose-depended effect. With the potential to elucidate the structure-activity …
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Discovery of Novel Tubulin Inhibitors and Selective Survivin Inhibitors for Advanced Melanoma and Total Synthesis of Bioactive 20S-hydroxyvitamin D3
… In particular, analogue 15i with a 4-indazole moiety showed the most potent antiproliferative activity against a panel of melanoma cell lines and had an average IC50 of 0.8 nM. This is the first sub-nM anti-tubulin compound in the related scaffolds.</p> <p>Chapter 5 will reveal our …
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Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds
… (MPTP). One such compound is 7-nitroindazole (7-NI), a compound which is reported to inhibit both enzymes. This thesis focuses on the synthesis and biological evaluation of a potential prodrug form of 7-NI and related indazolyl containing compounds which are designed to release the …