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Showing 1 to 10 of 10 for “"inclusion complexation"”.
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Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation
… their very low solubility in water. Cyclodextrin inclusion complexation and co-crystallization were carried out with the aim of ultimately improving the bioavailability of both drugs. Each new crystal phase isolated was analysed using X-ray diffraction, thermal and spectroscopic techniques. …
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The supramolecular derivatisation of pharmaceutically relevant compounds via co-crystallization and cyclodextrin inclusion complexation
… via co-crystallization and cyclodextrin (CD) inclusion complexation was attempted in order to produce new solid forms of these compounds for potential pharmaceutical applications. The pharmaceutically relevant compounds investigated included (a) three drug leads, namely …
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Antimicrobial and antioxidant active packaging incorporated with hop (Humulus lupulus L.) extract: development, characterization and application in meat product
… and their technological aspects, including complexation with cyclodextrins, prospects in active packaging development boosted to elaborate a comprehensive review in Chapter Article 1. Chapter Article 2, a commercial β- acids-rich hop extract was directly incorporated in different …
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Crystal engineering approaches to solid-state pharmaceutical systems
… it, via salt formation, co-crystal synthesis or inclusion complexation, for example. Presented in this work are three distinct approaches to the control and development of solid-state form of organic molecules and pharmaceuticals. The first of these approaches reports a novel, relatively simple …
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Drug-cyclodextrin complexes: an approach to enhance the solubility and dissolution properties of poorly soluble drugs
… manufacturing processes claimed to promote inclusion complexation between different drugs and cyclodextrins (econazole and α-cyclodextrin; indomethacin and methyl-β-cyclodextrin; olanzapine and methyl-β-cyclodextrin; flurbiprofen and methyl-β-cyclodextrin) in order to enhance the apparent …
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Encapsulation of tributyrin using various techniques to improve its intestinal delivery and sensory quality
… three fluid nozzles (2FN and 3FN, respectively), inclusion complexation and cross-linking of biopolymers. Various wall materials such as whey protein isolate (WPI), gamma-cyclodextrin (CD) and sodium alginate (AL) were selected based on their functionalities. The retention of TB and surface oil …
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Rapid separation of phenolic flavourings by liquid chromatography and nanomolar electrochemical detection at a boron-doped diamond electrode
… at a Nafion-modified BDD electrode. Inclusion complexation with cyclodextrins (CDs) and peak deconvolution reveals guaiacols, phenols and cresol isomers as the phenolic molecular fingerprint of whiskey. Pre-concentration with Nafion on the electrode surface results in a 5-fold …
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Carbohydrate Mediation of Aqueous Polymerizations: Cyclodextrin Mediation of Aqueous Polymerizations of Methacrylates
… reactivity of comonomer mixtures. In addition, complexation of cyclodextrin with guest molecules has been utilized in selective synthesis where the host cyclodextrin has been utilized to sterically hinder the attack of certain reactive sites contained within the host cavity. This aspect of …
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Preformulation solid-state supramolecular beneficiation of selected active pharmaceutical ingredients and a novel drug candidate
… polymorphs, solvates/hydrates, cyclodextrin (CD) inclusion complexes, pharmaceutical salts and co-crystals. Screening involved grinding and co-precipitation methods. Characterisation of new forms involved thermal analytical methods including hot stage microscopy (HSM), differential thermal …
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Non-covalent Intermolecular Interactions in Polymer Design: Segmented Copolymers to Non-viral Gene Delivery Vectors
… were investigated to study the non-covalent inclusion complexation with click cluster non-viral nucleic acid delivery vehicles for passive targeting of the click cluster-pDNA complexes (polyplex). Incorporation of adamantyl terminated poly(ethylene glycol) (Ad-PEG) and …