Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"inclusion complex"”.
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Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
… in literature between co-crystals and CD inclusion complexes. Upon selection of the efavirenz derivative, the complications of both small scale and large scale laboratory pre-formulation production is highlighted for formulation of a tablet dosage form. Numerous variables were selected for …
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Characterization of alpha-cyclodextrin inclusion complexes with trans-cinnamic acid in an acid-based beverage system
… was used as a host molecule to form an inclusion complex with the cinnamic acid molecule. The cinnamic acid: α-cyclodextrin inclusion complex was then characterized using phase solubility analysis, proton nuclear magnetic resonance (H-NMR), and solid inclusion. Phase solubility analysis …
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The supramolecular modification of trans-resveratrol and related antioxidant molecules
… These properties may be improved by inclusion complex formation with cyclodextrins (CDs) and by cocrystallisation with generally regarded as safe (GRAS) coformers. A study of the CD complexation of RES, CAF, FA, PCA, SA, 2H4M and 4H3M was carried out both in solution and in the solid …
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Development and characterisation of biosynthetic hydrogels for wound management applications
… supramolecular inclusion complex was produced by a solvent evaporation method. The ratios of solvents to solubilise curcumin and hydroxypropyl-β-cyclodextrin were tested for the production of the inclusion complex with optimum encapsulation efficacy. The results …
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Supramolecular derivatisation of bioactive molecules via co-crystallization and cyclodextrin inclusion complexation
… their very low solubility in water. Cyclodextrin inclusion complexation and co-crystallization were carried out with the aim of ultimately improving the bioavailability of both drugs. Each new crystal phase isolated was analysed using X-ray diffraction, thermal and spectroscopic techniques. …
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The preparation of cucurbit[8]uril-based hydrogels for delivery applications
… is capable of binding two guest molecules in an inclusion complex. Its addition to an aqueous solution of guest-functional polymers leads to the formation of cross-links and hydrogels. The first results chapter of this thesis explores the relationship between cross-link dynamics and molecular …
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The separations of picoline isomers by enclathration
… (picolines) were studied. Crystals of ten novel inclusion compounds were synthesised and their structural properties were further characterised using an array of techniques. Thermal analysis was also conducted on these and other TADDOL-derived inclusion compounds. Binary competition experiments …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… [polymorphs and cyclodextrin (CD) inclusion complexes], its derivative 2-methoxyestradiol-bis-sulfamate (polymorphs), and the antiretroviral agent, nevirapine (co-crystals). The solubility and dissolution profiles of the three compounds and those of selected …
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Design, synthesis and biological evaluation of antidiabetic agents
… diabetic condition. Disruption of the RBP4-TTR complex is a known method for decreasing the levels of RBP4. Therefore, reducing the levels of RBP4 provides a mechanism to treat/manage T2D and allows for the identification and synthesis of novel antidiabetic agents. Computational studies were …
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The use of cyclodextrin template-based metal oxide nanomaterials in the development of electrochemical sensors for phenolic endocrine disruptor compounds
… further by XRD. The ATR-FTIR analysis confirms inclusion complex between β-CD and nanoparticles. The nanoparticles synthesized were used to develop an electrochemical sensor for phenolic endocrine disruptors by modifying the surface area of glassy carbon electrode (GCE). Electrochemical …
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Electrochemical immunosensor based on cyclodextrin supramolecular interactions for the detection of human chorionic gonadotropin
… polymer (βCDPSH) to form a supramolecular inclusion complex with ferrocene (Fc)-functionalised carboxymethyl cellulose polymer (CMC). Cyclic voltammetry indicated that ferrocene is in close proximity to the electrode surface due to the supramolecular complex formed with βCDPSH. Furthermore, …
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Electrochemical Immunosensor based on Cyclodextrin Supramolecular interactions for the detection of human chorionic gonadotropin
… polymer (βCDPSH) to form a supramolecular inclusion complex with ferrocene (Fc)-functionalised carboxymethyl cellulose polymer (CMC). Cyclic voltammetry indicated that ferrocene is in close proximity to the electrode surface due to the supramolecular complex formed with βCDPSH. Furthermore, …
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Electrochemical immunosensor based on cyclodextrin supramolecular interactions for the detection of human chorionic gonadotropin
… polymer (βCDPSH) to form a supramolecular inclusion complex with ferrocene (Fc)-functionalised carboxymethyl cellulose polymer (CMC). Cyclic voltammetry indicated that ferrocene is in close proximity to the electrode surface due to the supramolecular complex formed with βCDPSH. Furthermore, …
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The Development of Chitosan Microspheres for Use as Agrochemical Delivery or Agropollutant Adsorption Systems
… sodium salt is known to form a stable inclusion complex with a herbicide called paraquat. The hydrogel beads were characterised using scanning electron microscopy and energy dispersive X-ray analysis. Adsorption experiments were performed using UV/vis spectroscopy and it was found that …
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Preclinical pharmacokinetic evaluation of novel antimalarial and antituberculosis drug leads
… antimalarial compound in its cyclodextrin inclusion complex revealed a pH dependent increase in solubility that reduced variance, likely due to favoured intestinal absorption. Investigation of two novel fusidic acid C-3 ester prodrugs aimed at repositioning fusidic acid for tuberculosis, …
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Cyclodextrin complexes of antimicrobial agents
… (CyD) due to the formation of a water-soluble complex between the drug and dissolved CyD. This study investigated the interactions of -Cyd and hydroxypropyl--CyD (HP--CyD, M.S. = 0.6) with antimicrobial agents of limited solubility in an attempt to increase their microbiological efficacy. The …
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Controlled Release of Natural Antioxidants from Polymer Food Packaging by Molecular Encapsulation with Cyclodextrins
… were to (1) form and characterize cyclodextrin inclusion complexes with the natural antioxidants, alpha-tocopherol and quercetin, (2) incorporate cyclodextrin inclusion complexes of natural antioxidants into linear low density polyethylene (LLDPE), and (3) measure the release kinetics of …
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Formation, Characterization and Stability of Natural Antimicrobial-Cyclodextrin Complexes
… cinnamic acid, and citronellol were complexed with α- and β-cyclodextrin and evaluated through phase solubility analyses. The complexes formed showed improved aqueous solubility for all compounds. Complexation with α-CD resulted in an increase of aqueous solubility of …
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Crystal engineering approaches to solid-state pharmaceutical systems
… it, via salt formation, co-crystal synthesis or inclusion complexation, for example. Presented in this work are three distinct approaches to the control and development of solid-state form of organic molecules and pharmaceuticals. The first of these approaches reports a novel, relatively simple …
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Development of antibiotic microneedle delivery systems for tuberculosis treatment
… drug compared to the other three, the inclusion complex between RIF and cyclodextrin was developed. Moreover, formulations of each drug reservoir type were optimised to achieve a rapidly dissolving tablet, and further integrated with hydrogel-forming MN arrays for in vitro permeation …
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