Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"inclusion body"”.
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Mitochondrial Biology in Sporadic Inclusion Body Myositis
Sporadic Inclusion Body Myositis (sIBM) is an inflammatory muscle disease that strikes individuals at random and accounts for approximately 1/3 of all idiopathic inflammatory myopathies. It is characterized by progressive weakness of distal and proximal muscles and is the most common muscle …
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Inclusion body hepatitis as a primary disease in commercial broiler chickens
Inclusion body hepatitis (IBH) has been occurring as an economically important, emerging disease of broiler chickens in several countries. Historically, IBH has been identified as a secondary disease, often associated with common immunosuppressive diseases. However, few studies have identified IBH …
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HIV-Polymyositis progressing to inclusion body myositis: clues to earlier diagnosis
… include polymyositis (PM), dermatomyositis and inclusion body myositis (IBM). Although PM is still mentioned, it is thought to be rare since the discovery of myositis autoantibodies. In the last few years it has been reported that several cases who were initially diagnosed as HIV-associated PM …
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Parallels and Divergences in Multisystem Proteinopathy Genes: Stress Granules, Autophagy, and Myogenic Deficits
… is a disease that causes some combination of inclusion body myopathy with rimmed vacuoles, Paget’s disease of bone, and ALS/FTD. Several different genes give rise to the unique phenotypic expression of MSP. Given the variety of genes that cause MSP and the specificity of the phenotype and …
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Sjúkdómar í kjúklingaeldi á Íslandi með áherslu á smitandi sjúkdóm í búrsu (Gumboroveiki)
… á þessum lista eru innlyksa lifrarbólga (e. inclusion body hepatitis) og smitandi sjúkdómur í búrsu (e. infectious bursal disease) (IBD). Þann 23. ágúst 2019 tilkynnti Matvælastofnun tilfelli á tveimur sjúkdómum í kjúklingum á Jarlsstöðum í Landsveit sem ekki höfðu áður valdið vandræðum í …
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Characterization of the insecticidal crystal protein from Bacillus thuringiensis.
Bacillus thuringiensis produces a crystalline inclusion body composed of a 130-kDa protein which is rendered toxic upon ingestion by lepidoteran larvae. It was shown that proteinases adsorb on the surface of the crystalline body lead to proteolysis of the protein crystal especially on …
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High-throughput evaluation of protein folding conditions and expression constructs for structural genomics
… nicht korrekt gefaltet ist und in unlöslichen Inclusion Bodies anfällt. In manchen Fällen ist die Analyse von Deletionskonstrukten oder einzelnen Proteindomänen der Untersuchung des Vollängeproteins vorzuziehen. Dies umfasst die Herstellung eines Satzes von Expressionskonstrukten, welche …
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Relationship Between TDP-43 Toxicity and Aggregation in Saccharomyces Cerevisiae
<p>Protein aggregation and inclusion body formation are hallmarks of neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS). These neurodegenerative diseases share a common pathology in that all include accumulation of insoluble protein …
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
… documents various strategies for combating "inclusion body" formation in the overexpression ofPXR. Also, it describes the production of plasmid pCMV-RXR for transfection into the HepG2 cell line to monitor the levels of cellular RXR in various tissue types.</p>
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The Novel Purification and Biophysical Characterization of CXC Chemokines
… yet to be established. In this work, a novel, inclusion body purification is developed to express and purify biologically active CXCL chemokines in milligram quantities for thermodynamic and kinetic biophysical characterization experiments. The results show, that the CXCL chemokines folds and …
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Biomechanical and physiological investigations in the IBMPFD animal model
Inclusion body myopathy associated with Paget’s disease of bone and frontotemporal dementia (IBMPFD; OMIM 167320) is an autosomal dominant inherited multisystem disorder caused by mutations in the valosin-containing protein (VCP) gene. Knock-in mice expressing the common human p.R155H VCP mutation …
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NOVEL ASPECTS OF ULTRASTRUCTURE IN TWO SPECIES OF CYANOBACTERIA (AGMENELLUM QUADRUPLICATUM, MASTIGOCLADUS LAMINOSUS)
… the cell. Some of the various intracellular inclusion bodies were always peripherally located, while others were always centrally located. The detailed three-dimensional arrangement of subcellular features was remarkably consistent from one cell to another.</p><p>The morphology and …
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Metabolic Pathways for Natural and Unnatural Sialic Acids
… pathway are implicated in hereditary inclusion body myopathy (hIBM), a disease of aging. In Chapter 2, I determined that sialic acid biosynthesis alters the levels of UDP-GlcNAc, a product of the hexosamine biosynthetic pathway. This results in changes in the branch structure of …
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Identification and Characterization of Aer, an Energy Sensor in Escherichia Coli
… of Aer. However, the N-terminus peptide formed inclusion bodies. Co-expressing the GroESL chaperonins alleviated inclusion body formation and increased the solubility of Aer.</p>
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Characterising the role of Valosin Containing Protein (VCP) in autophagy and cell differentiation.
… rise to the complex disease syndrome known as Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD). VCP plays a key role in the ubiquitin-proteasome dependent protein degradation although mutations in VCP seem to result in a late stage autophagy defect. …
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A Systematic Method for Enhanced Expression of Alcohol Dehydrogenases in Escherichia coli
… achieved, challenges such as the formation of inclusion bodies, present limitations that inhibit streamlined manufacturing of recombinant enzymes. The lack of consistent workflows to address enzyme solubility issues often results in difficulties in producing high quantities of catalytically …
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Molecular Genetic Analysis of Spinocerebellar Ataxia Type 7 and a Further Study on the RNA Interference Analysis
… shRNAs significantly decreased the nuclear inclusion body (aggregation) generated by over-expression of YFP-Ataxin-7 (55Q) in HeLa cells. Our results suggest that a combination of two shRNA systems for allele-specific and non-specific silencing of mutant Ataxin-7 may produce an additive …
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Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
Die sporadische Einschlusskörpermyositis (sIBM) ist eine chronisch progrediente Muskelerkrankung. Im Muskelgewebe von sIBM-Patienten gibt es eine Anhäufung degenerativer Moleküle, inflammatorischer Infiltrate und von Zellstressmolekülen. Ziel der vorliegenden Arbeit war es, einen möglichen …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… sclerosing panencephalitis (SSPE), and Measles inclusion body encephalitis (MIBE). Currently, there is no cure for these MV-related neurological conditions, which occur overwhelmingly in newborns and children. Thus, the goal of this project is to define how neonatal immunity responds to MV …
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Identifikation und funktionelle Charakterisierung von Effektorproteinen des Typ III Sekretionssystems von Chlamydophila pneumoniae
Chlamydophila pneumoniae verursacht atypische Pneumonien und wird darüber hinaus mit einigen chronischen Erkrankungen wie chronisch obstruktiver Lungenerkrankung oder Arteriosklerose in Verbindung gebracht. Der gesamte Entwicklungszyklus der obligat intrazellulären Chlamydien findet in der …
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