Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"inbred mouse strains"”.
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Peripheral Taste System in Inbred Mouse Strains
Taster and non-taster mice strains have been used extensively in animal taste research. Inbred mouse strains C57 and FVB have been proposed to be tasters, where as strains 129 and Balb/C are classified as non-tasters. Therefore, evaluating the peripheral taste system in these mice is of great …
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Genetic Effects Mediated Through Epistatic Networks Onto Metabolic Traits
… used an advanced intercross of the LG/J and SM/J inbred mouse strains to unravel the genetic architecture of multiple metabolic traits. These studies found that parent-of-origin effects are surprisingly common, and that they can be mediated by the environment. This indicates that our ability to …
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Heritable variation in reward sensitivity and impulsive cction and choice in a genetically diverse inbred mouse panel
… drugs. The Collaborative Cross (CC) recombinant inbred mouse strains and their inbred founders are a powerful genetic reference panel that has potential as a tool for revealing genetic correlations. The CC/DO founder strains were used to examine the heritability of reward sensitivity and …
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… permanent, focal cerebral ischemic stroke mouse model to investigate genetic factors of ischemic stroke outcome measured by infarct volume. This model is the middle cerebral artery occlusion (MCAO) model. First, we screened infarct volumes across 32 inbred mouse strains. The infarct volume …
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Analysis of variation in PIWI-interacting RNA (piRNA) expression in testes of different mouse strains
… of piRNAs in the male germline of five inbred mouse strains. We tested for variation in piRNA expression between different mouse strains. Furthermore, we tested whether variation in transposon copies between mouse strains affects the expression of piRNAs. We analyzed piRNA expression …
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The Genetic Basis of Susceptibility to Therapy-related Leukemia in Mice
… candidate risk factors, cohorts of twenty inbred mouse strains were treated with N-ethyl-N-nitrosourea (ENU), a potent alkylating agent in mice. Six of these mouse strains were susceptible to alkylator-induced leukemia. SWR/J mice were the most susceptible in this relatively small screen. …
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Pathological and genetic analysis of host susceptibility to cardiovirulent coxsackievirus B3 infection in mice
… phenotypic traits were characterized. Three inbred strains of mice and two congenic strains were infected with CVB3. Differences in survival, body weight loss, quantification of myocarditis and quantification of sarcolemmal disruption were found by comparing three sets of mice sharing the …
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Bone Tissue Quality Determination of Mice Through a Novel Reference Point Indentation Technique
… in fracture toughness that exist between inbred mouse strains with genetically based differences in mineralization. To achieve this we measured a new parameter called Indentation Distance Increase (IDI) which has been shown to be related to fracture toughness. We also analyzed associated …
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Variation in chromosomal aberration induction in differing ATM and ASPM genotypic backgrounds detected via a modified PNA FISH technique
… was used to detect a heightened sensitivity in mouse fibroblasts in response to ionizing radiation with Atm-/- and in mouse embryonic fibroblasts (MEFs) in response to loss of Aspm gene respectively. For Atm analysis, four commonly used inbred mouse strains were used, C57BL/6J, A/J, 129S6, and …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
… variability has been demonstrated in the mouse; a proportion of this variability is due to inherited genetic factors. We present genetic correlation analyses of 22 nociceptive measures among a common set of inbred mouse strains, revealing the existence of five fundamental ""types"" of …
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Investigating the molecular underpinnings of major depressive disorder and the utility of biomarkers in the inflammatory cytokine pathway as aids for clinical diagnosis and treatment selection
… a model of early life stress in two inbred mouse strains, we<br/>investigated the transcriptional effects of maternal separation. The top stress by<br/>strain interaction was found in the telomerase RNA component gene (Terc). We<br/>also found that a single nucleotide polymorphism in …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… hybridoma clone enables characterization of the mouse Nkrp1-Clr receptor-ligand system via in vitro reporter cell and transfection approaches. Next, we show that the Nkrp1-Clr receptor-ligand system exhibits substantial allelic polymorphisms in NKR-P1B, NKR-P1C, and Clr-c loci between three …
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Studies on the Inheritance of Idiotypic Markers of Mouse Antibody to Streptococcal Group A Carbohydrate and on Other Genetic Factors Which Influence the Immune Response
… A streptococcal carbohydrate was measured in 10 inbred mouse strains after immunization with whole heat-killed streptococcal vaccine. Using A/J and SWR/J mice, dose response studies were performed to determine optimai immunization conditions of dose, route of injection, and age of mice. In the …
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Osseointegration of a Cementless Total Knee Arthroplasty in a Murine Model of Glucocorticoid Induced Osteoporosis
… osseointegration and biomechanical strength. The mouse model used in this study consists of a laser sintered titanium beaded tibial component (2mm long, 1mm diameter) from which biomechanical pullout strength and bone ingrowth can be readily measured. The goal of the current study was to assess …
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Variable DNA methylation in the mouse genome: repetitive elements, unique regions and functional implications
Approximately 10% of the mouse genome consists of endogenous retroviruses (ERVs), a class of retrotransposon, which includes the murine-specific intracisternal A particle (IAP) elements. To prevent their mobilisation and suppress the function of the TE- encoded regulatory sequences, TEs are …
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Genetic Analysis of Variation in Neuron Number
… contributing to variation in neuron number among inbred strains of mice. I have focused on variation in neuron number on a large scale, by using the surrogate measure of whole brain weight, and variation within a distinct neuron population, retinal ganglion cells.</p> <p>Brain weight ranges from …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… cannabis, between highly genetically divergent inbred mouse strains—C57BL/6J (B6) and DBA/2J (D2). To identify variation in THC response we use the cannabinoid-induced tetrad test which quantifies the strength of agonist mediated cannabinoid receptor signaling by measuring the level of motor …
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Using Genome-wide Approaches to Characterize the Relationship Between Genomic Variation and Disease: A Case Study in Oligodendroglioma and Staphylococcus arueus
… to <italic>S. aureus</italic> infection in inbred mouse strains. We conducted ISHM on four phenotypes collected from <italic>S. aureus</italic> infected mice and identified genes contained in the significant regions, which were considered to be potential candidate genes. Gene expression …
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MATERNAL DETERMINANTS OF OOCYTE AND EMBRYO QUALITY
… of oocytes obtained from two different inbred mouse strains, B6 and D2, and F1 hybrid. A clustering analysis and statistical tests showed that the transcriptome of F1 oocytes is more similar to the B6 transcriptome than to the D2 at both GV and MII stages. Also, comparison analyses of GV …
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Development and application of OmpT-based middle down proteomics
… same workflow is used to qualitatively compare mouse brain proteomes between two inbred mouse strains. After searching the middle-down data against strain-specific databases, 1,934 peptides (average size: 6.0 kDa) were identified from 714 proteins in the high-mass region of the mouse proteome …