Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"inborn errors of immunity"”.
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Human Inborn Errors of Immunity: Tuberculosis, Autoimmunity, and Beyond
… most predominantly M. tuberculosis, remains one of the deadliest infectious diseases in human history. Bacillus Calmette-Guérin (BCG) vaccine, first implemented medically in 1921, has remained the only available vaccine for TB, although its protective effect is moderate. TB occurs in 5-10% of …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… (CNS), and the most common cause is HSV-1. Inborn errors of immunity (IEIs) have demonstrated that neuron, cell type-specific, antiviral immunity is essential to prevent viral infection and encephalitis. However, despite these key advances in human genetics, relatively little is known about …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
… disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn Errors of Immunity (IEI) shed light on the molecular and cellular requirements …
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Common variants in antibody deficiencies
The inborn errors of immunity (IEIs) comprise a group of almost 500 diseases charac- terised by immune dysfunction of genetic origin. Many of these disorders represent canoni- cal examples of Mendelian disease and study of their genetic aetiology is largely conducted within a rare-variant, …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
The emergence of SARS-CoV-2 and the subsequent onset of the COVID-19 pandemic led to the rapid development of vaccines against the virus. Two of the major vaccines administered in the UK and elsewhere utilised novel mRNA technology to produce an immune response against the viral spike protein. The …
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Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment
Long-term immunity is shaped by the immune system's interactions with infectious agents or vaccinations. In individuals with immune dysregulation, such as patients with primary immunodeficiency (PID) or rheumatic diseases, these interactions are altered. Plasma cells (PC) and their B cell …
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Genomic investigation of primary immunodeficiency
… immunodeficiencies (PIDs) are a collection of rare diseases which effect one or more components of the human immune system and are typically considered monogenic. PID presents with features including increased susceptibility to infection, autoimmunity, autoinflammation, atopy and malignancy. …