Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"in-vivo tissue"”.
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Optical biopsy of in vivo tissue using optical coherence tomography
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
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Addressing Challenges of Volume Controlled Cavity Expansion (VCCE) for In-Vivo Tissue Testing
The prevalence of Traumatic Brain Injuries (TBI’s) is a serious health concern to U.S. Military Members. Mild TBI’s, some of which have been shown to result from prolonged exposure to repeated artillery blasts, are particularly challenging to identify with existing diagnostic imaging technology. In …
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A non-clinical method to simultaneously estimate thermal conductivity, volumetric specific heat, and perfusion of in-vivo tissue
… volumetric specific heat, and perfusion of in-vivo tissue. The heat transfer through the tissue was modeled using a modified Pennes' equation. Using a least-squares parameter estimation method with regularization, the thermal properties could be estimated from the temperature response to the …
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Optical diagnostics for oral and gastrointestinal tract pathologies
… burden. They are a precursor to oral cancer and indicate a tissue with a higher risk of developing a malignancy. Early diagnosis can improve patient outcomes by minimally invasive treatment, reduced mortality rate and improved post-treatment life quality. Despite the availability of advanced …
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Fabrication of tissue scaffolds using projection micro-stereolithography
In vitro liver models are a critical tool in pharmaceutical research, yet standard hepatocyte cultures fail to capture the complexity of in vivo tissue behavior. One of the most critical features of the in vivo liver is the extensive microvasculature which allows for the delivery of nutrients and …
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Development Of An Accurate Benchmarking System For Microwave Breast Imaging
… of the design and implementation of benchmarking system for microwave imaging systems. The current benchmarking tools for microwave imaging setups are not adaptable. A novel method for of the development of a dielectric phantom using regression analysis is presented. This is followed by a …
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Development of microfluidic devices to maintain and interrogate tissue biopsies - biomedical applications
Currently most cell-based methodologies in microfluidic systems utilize homogeneous or heterogeneous cell populations. However, these systems do not present an accurate representation of in vivo dynamics. A microfluidic based experimental methodology has been developed that offers a biomimetic …
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Hybrid Microfluidic Sensing Platforms for Cancer Cell Study: Recent Advances and Future Prospects
… of mammalian cell culture is vividly seen in biotechnology, drug screening, and large-scale pharmaceuticals production. There have been numerous efforts in designing an automated cell culture system replicating the natural microenvironment of the cells to improve throughput analysis with …
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Spatially-localized correlation of MRI and mechanical stiffness to assess cartilage integrity in the human tibial plateau
Osteoarthritis is a painful degenerative joint disease affecting millions of people in the U.S. The pathogenesis of articular cartilage disease is characterized by softening of cartilage and loss and disruption of constituent macromolecules including proteoglycans and collagen. In current …
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3D printing of hyaluronic acid scaffolds for tissue engineering applications
… biodegradeable polymer, for cell culture and tissue engineering applications. HA is functionalized with UV-curable glycidyl methacrylate (GM) and printed to create 3D scaffolds with filament diameters ranging from 10-250 µm. The potential for 3D HAGM scaffolds in injectable applications is …
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Defining cellular microenvironments using multiphoton lithography
To understand the chemistry of life processes in detail is largely a challenge of resolving them in their native, cellular environment. Cell culture, first developed a century ago, has proven to be an essential tool for reductionist studies of cellular biochemistry and development. However, for the …
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Magnetomicrometry : tissue length tracking via implanted magnetic beads
Target tracking is necessary across a wide range of disciplines and scales, such as in monitoring tissues and cells, beam bending, fluid dynamics, human-computer interaction, and traffic. Due to these widespread applications, advances in target tracking drive cascades of new medical, social, and …
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In vivo and ex vivo techniques using elastic scattering spectroscopy for diagnosis of malignancy in the thyroid gland
… Thyroid cancer is the most common endocrine malignancy and patients presenting with thyroid nodules often undergo surgery solely for diagnostic purposes. The goal of our study was to examine the accuracy of Elastic Scattering Spectroscopy (ESS) in distinguishing between benign and …
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The Molecular Basis of Tissue Elasticity and Force Balance During Drosophila Gastrulation
The mechanics of folding any material rely on two things: the physical forces forming the fold and the material properties of the substance being folded. When working in biological tissue such as an early Drosophila embryo, there is no existing way to directly measure morphogenetic forces, and the …
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Magnetic resonance elastography and nonlinear inversion problem in the aging brain
The history of medical imaging has centered on finding correlations between contrast in an image and diagnosis of a disease, but there is a shift in medical imaging from contrast towards quantitative measurements as disease biomarkers. Magnetic resonance elastography (MRE) is a non-invasive imaging …
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Cardiac tissue engineering : bioreactor cultivation parameters
Tissue engineering may be useful in fighting heart disease since it offers the possibility of creating functional tissue equivalents for scientific studies and tissue repair. In the present work, we examined how variations in cultivation parameters of a model tissue engineering system influenced …
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Investigating the Impact of Biochemical and Mechanical Stimuli on Motor Neuron Growth
Peripheral nerve injuries are one of the most prevelant trauma injuries, and the current golden standard for treatment is an autologous nerve graft. The use of tissue engineered nerve grafts has increased in recent years, a neural scaffold, cellular or acellular, is utilized to promote nerve …
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Engineering M13 Bacteriophage Nanoplatforms for Diagnostic and Therapeutic Applications
… nanostructure, consists of thousands of distinct protein subunits organized in a filamentous viral capsid; 900nm in length and 6nm in diameter. All M13 capsids are amenable to mutation and can be tuned for the binding and nucleation of inorganics and nanoparticles, and for the expression of …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
Within the past decade, there has been abounding scientific evidences supporting the notion that mechanical forces are crucial in regulating the physiologic functions of cells and tissues. The importance of engineering principles in studying the biological behavior of cells is no longer in …
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Chemomechanics at cell-cell and cell-matrix interfaces critical to angiogenesis
… to characterize and control cellular responses in vitro has far reaching implications for basic science and applied medical research. For well over 125 years, researchers have studied the behavior of biological cells under in vitro conditions where rigid glass or plastic Petri dishes and defined …
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