Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 885 for “"in-silico"”.
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In silico systems analysis of biopathways
In the past decade with the advent of high-throughput technologies, biology has migrated from a descriptive science to a predictive one. A vast amount of information on the metabolism have been produced; a number of specific genetic/metabolic databases and computational systems have been developed, …
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Interpreting the genome physically in-silico
Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2017.
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An In silico Liver: Model of gluconeogenesis
An in silico liver was developed in attempt to represent the in vivo state of the fasted liver. It featured two conceptual models. The first one represented carbohydrate metabolism of the human liver, which included the heterogeneous nature of the liver by incorporating spatial variation of key …
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In silico tools for the development of biotherapeutics
The production of a new drug is an inherently risky process. While there are many causes for failure, a number of these are due to the many potential degradation pathways a protein can undergo. Often these reactions are slow and negligible. However, there are times where any one of these reactions …
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Actin dynamics in silico, in waves, and in rods
The current paradigm of actin dynamics and superorganization has advanced in the past decade from emerging technologies and perspectives, which include the discovery of actin nucleators, real time imaging of the dynamics of single filaments in vitro, and single molecule imaging of actin …
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In silico approaches to investigating mechanisms of gene regulation
Identification and characterization of regions influencing the precise spatial and temporal expression of genes is critical to our understanding of gene regulatory networks. Connecting transcription factors to the cis-regulatory elements that they bind and regulate remains a challenging problem in …
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In silico models for biomedical applications of magnetic nanoparticles
… è presente nell'allegato / the abstract is in the attachment
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In silico bacterial gene regulatory network reconstruction from sequence
DNA sequencing techniques have evolved to the point where one can sequence millions of bases per minute, while our capacity to use this information has been left behind. One particularly notorious example is in the area of gene regulatory networks. A molecular study of gene regulation proceeds one …
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Étude in silico de cristaux liquides : reconnaissance de domaines structuraux
Les matériaux auxétiques sont d’un grand intérêt pour leurs propriétés d’absorption d’impacts. Ils sont caractérisés par la présence d’un coefficient de Poisson négatif, c’est-à-dire que les matériaux auxétiques peuvent se densifier localement sur le point d’impact, ce qui est une propriété …
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Saccharomyces cerevisiae élesztőgomba genomstruktúrájában történő mesterséges változtatások "in silico" módszerrel
… S288C genomstruktúrájában végeztem el „in silico” módszerrel mesterséges mutációkat. 4 mesterséges mutációt hajtottam végre, az így kapott eredményeket SimuSCOPE-szoftver segítségével értékeltem ki. Az így kapott filogenetikai fa alapján, azt a megállapítást tettem, hogy a bioinfomatikai …
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In Silico Evolution of Oscillating Mass-Action Chemical Reaction Networks
… algorithms, a class of optimization techniques inspired by biological evolution,have emerged as powerful tools for the optimization of complex systems, including the evolution of mass-action chemical reaction networks. This dissertation explores the application of evolutionary algorithms in this …
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In vitro and in silico profiling to assist pharmaceutical development
During the pharmaceutical development process of a new drug it is necessary to fully elucidate the physico-chemical properties of the molecule in order to find the appropriate formulation. For drugs intended to be administered orally water-solubility is a an essential requirement. The development …
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In silico-aided design, build and test of synthetic proteins
Since the discovery of proteins in 1838, the field of protein engineering and our understanding of proteins have improved exponentially. Synthetic proteins have found applications in various biomedical, food and material-based settings. This rise in synthetic proteins was complemented with the …
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In silico testing of glucose controllers : methodology and sample application
… by hyperglycaemia due to deficient or absent insulin secretion, insulin action, or both. In particular, Type 1 diabetes is characterised by a total lack of endogenous insulin secretion which has to be replaced by exogenous insulin to control the plasma glucose concentration. An extracorporeal …
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Modification and regulation of biomolecules in vitro and in silico
Made available in DSpace on 2017-03-01T17:01:53Z (GMT). No. of bitstreams: 4 CHAO-DISSERTATION-2016.pdf: 46584356 bytes, checksum: d3f45ec92d145f3f283e881146e0871b (MD5) JCE_Springer.pdf: 93928 bytes, checksum: e17be616416d3f9170c36fe13bf9811f (MD5) LICENSE.txt: 4209 bytes, checksum: …
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Three-dimensional, in-silico breast phantom for multimodality image simulations
… of anatomically realistic three-dimensional in-silico breast phantoms with adjustable sizes, shapes and morphologic features. The concept of multiscale spatial resolution is implemented for generating breast tissue images from multiple modalities. Breast epidermal boundary and subcutaneous …
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Improved In Silico Methods for Target Deconvolution in Phenotypic Screens
Target-based screening projects for bioactive (orphan) compounds have been shown in many cases to be insufficiently predictive for in vivo efficacy, leading to attrition in clinical trials. Phenotypic screening has hence undergone a renaissance in both academia and in the pharmaceutical industry, …
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Protein and Peptide Solubility - In Silico and In Vitro Approaches
Solubility is a crucial property to optimise in the development of peptides and proteins as therapeutic compounds. Biologics, which are drugs based on biological compounds such as proteins, inherently possess many beneficial properties such as low toxicity and high specificity. Often, however, they …
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