Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"in vivo stimulation"”.
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MAdCAM-1 expression and function in human liver
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a tissue–specific protein that promotes α4β7+ lymphocyte recruitment on gut mucosal endothelium, playing an important role in the development of inflammatory bowel disease (IBD). Recent studies have reported its expression in liver diseases …
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A possible role for intrinsic calcium buffers in the long- term adaptation of crayfish neurons
Increasing the impulse activity of neurons in vivo over 3 or more days causes a reduction in transmitter release that persists for days or weeks (eg. Mercier and Atwood, 1989). This effect is usually accompanied by decreased synaptic fatigue. These two changes involve presynaptic mechanisms and …
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Regulation of cortisol secretion in humans: relation to vasopressin action at the adrenals in macronodular and micronodular adrenocortical tumours; and well-being in Addison’s Disease.
… regulation on a circadian and ultradian basis in humans. Key central regulators include the peptides corticotrophin-releasing hormone (CRH) and arginine vasopressin (VP), acting at the pituitary, and at peripheral structures relevant to the HPA axis and other components of the stress system. …
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Layer specific differences in the mouse auditory corticocollicular system
Recent data suggest that there may be distinct processing streams emanating from auditory cortical layer 5 and layer 6 that influence the auditory midbrain. To examine the functional properties of neurons in these two layers that project to the midbrain, we performed three sets of experiments. …
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Genomic profiling of response to $\textit{in vivo}$ immune perturbations
The human immune system plays a central role in defense against infection, but its dysregulation is implicated in immune-mediated diseases. The past decade has seen increasing application of high-throughput technologies to profile, predict, and understand immune response to perturbation. The …
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5 ns Electric pulses evoke longer-lived calcium responses in adrenal chromaffin cells than the physiological stimulus: an experimental and computational study
… high electric field magnitudes (>1 MV/m) are being explored by our group as a novel type of electric stimulus for evoking catecholamine release from neuroendocrine adrenal chromaffin cells. The overall goal of this work is to understand why 5 ns, 5 MV/m pulses evoke longer-lived calcium …