Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"in vivo siRNA delivery"”.
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Elucidation of Design Criteria for siRNA Delivery in Mammalian Cells Using Polyethylenimine
The research presented in this thesis addresses the issue of how PEI concentration affects siRNA delivery efficiency. It also examines how PEI derivatives affect the three primary in vitro barriers: (1) cellular uptake, (2) endosomal escape, and (3) unpackaging of PEI/siRNA polyplexes. Chapter 2 …
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Mouse Models of Inherited Skin Diseases
… keratoderma (EPPK) is an autosomal-dominant keratin disorder. It is clinically characterised by diffuse hyperkeratosis of the palms and soles, demarcated by an erythematous border. Mutations altering the coding sequence of the keratin 9 (KRT9) gene, a palmoplantar-specific type I …
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Role and Regulation of Epha2 In Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cancer cause of death in the US. Gemcitabine is the first-line therapy for this disease, but unfortunately it shows only very modest benefit. The focus of the current study was to investigate the role and regulation of EphA2, a receptor …