Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"in vivo screen"”.
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Functional In Vivo Screen Identifies Pygo2 As A Putative Gene to Promote Prostate Cancer
… chromosomal copy number alterations, highlighting the potential function of genes with copy number gains and losses in driving prostate cancer progression. To identify putative genes promoting prostate cancer, an <em>in vivo</em> tumorigenesis screen was performed for 286 genes that are …
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Development of P7C3-Class of Neuroprotective Molecules
… and disorders are physically, emotionally and financially devastating for patients and their families, and are also associated with great costs to caregivers and society. All of these neuropsychiatric conditions have in common neuronal cell death, for which there is currently no effective …
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African Trypanosome Genes Specifically Required for Fitness <i>in vivo</i>
This report details the initial validation of hits from a genome-scale RNAi fitness screen to reveal genes that showed a specific loss of fitness in vivo. Analyses of African trypanosome biology are often carried out in HMI culture medium which is rich in nutrients and may not necessarily be …
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SYNTHESIS OF a,ß-UNSATURATED-1,3-DIKETONES AND RELATED MANNICH BASES FOR EVALUATION AGAINST VARIOUS NEOPLASMS
In the chemical warfare against cancer, different classes of drugs are employed. However, since a majority of these drugs have been developed with a common target in mind, namely DNA, they have the potential of being carcinogenic and mutagenic. In addition they are associated with host toxicity and …
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A biosynthetic approach to the discovery of novel bioactive peptides
… for recalcitrant human diseases, but screening for bioactivity from natural or synthetic sources can be uneconomic. In contrast, in vivo expression of peptides from DNA libraries in a heterologous host such as Escherichia coli may combine production with screening. This dissertation …
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Identifying Epigenetic Regulators Of Tumor Dormancy And Recurrence
Part 1: Breast cancer remains the leading cause of cancer mortality in women, largely due tometastatic recurrence. Recurrent tumors arise from residual tumor cells, which can survive cancer therapy and stay dormant for an extended period of time. Despite their clinical importance, the biology of …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
… is characterized by growth of the primary tumor in the colon followed by metastasis to distant organs. The metastatic cascade involves invasion of cells from the primary tumor into the surrounding tissue, entering into and survival of cancer cells in the circulation, arrival at the end organ and …
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P4HB TARGETING HALTS TUMOR GROWTH AND RE-SENSITIZES RESISTANT MELANOMA CELLS TO DABRAFENIB AND TRAMETINIB STANDARD-OF-CARE THERAPY VIA IRE1-⍺ ACTIVATION AND AKT DOWNMODULATION
… patients was dramatically improved by the introduction of targeted therapy (BRAF and MEK inhibitors) and immune checkpoints inhibitors (anti-PD1, anti-CTLA4). However, a significant proportion of BRAF-mutant patients develop secondary resistance to targeted therapies, while others exhibit …
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In Vivo Kinome Screen Reveals Non-Canonical Cdk-Driven Metabolic Adaptation In Brain Metastasis
<p>Brain metastasis, which frequently arises from breast cancer, lung cancer, melanoma, and colorectal cancer, remains a severely unmet medical need and its incidence continues to rise while treatment options remain palliative. To better understand the biology underlying its aggressive, incurable …
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Membrane protein biosynthesis at the endoplasmic reticulum
The biosynthesis of integral membrane proteins (IMPs) is an essential cellular process. IMPs comprise roughly 20-30% of the protein coding genes of all organisms, nearly all of which are inserted and assembled at the endoplasmic reticulum (ER). The defining structural feature of IMPs is one or more …