Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"in vivo mouse model"”.
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Involvement of Histone Deacetylase 4 (HDAC4) in Osteoclast Function
Bone modeling and remodeling during development and bone integrity throughout life are normally regulated via complex coupled actions of bone-resorbing osteoclasts and bone-forming osteoblasts. Loss of coupling between bone formation and bone resorption leads to pathogenesis of bone metabolic …
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Interneuron networks and cortical dynamics : emulated whisking drives SOM interneurons in the ketamine anesthetized mouse SI neocortex
In the core of this thesis I test and confirm the hypothesis that separate classes of interneurons respond differentially to sensory stimulation independent of volitional or other top-down control on the part of the animal. I also test and confirm the hypothesis that, based only on bottom-up …
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Mouse Melanoma Model for Evaluating Anti-Cancer Effects of Nanoparticles, Composites and Conjugates
… by the immune system and to use expressed cytokines and factors for their advanced growth and metastasis. This disease may be hindered by the targeting of a poly I:C-nanoconjugate treatment. This study will examine the potential of poly I:C and specific nanomaterials in combination to target …
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Role of Chlamydia trachomatis infection in adverse pregnancy outcomes
… been associated with adverse pregnancy outcomes including controversial data on miscarriage, intrauterine growth restriction and low birth weight, however the causative mechanisms are unknown. A successful pregnancy requires normal endometrial stromal cell (ESC) decidualisation and trophoblast …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… bronchiectasis are characterised by cycles of inflammation and infection. Long term antibiotics are commonly prescribed in these conditions to decrease exacerbation frequency and improve quality of life. Azithromycin is often given orally for this purpose with its benefit thought to be due to a …
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Effects of n-acetylcysteine amide in preventing/treating cataracts
… pathological abnormality of the lens accounting for approximately 50% of all blindness. The only effective treatment currently available for a cataract is the surgical removal of the affected lens and replacement with an artificial lens for the restoration of vision. Although, cataract …
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The Role of Qa-2, the Functional Homolog of HLA-G, in a Mouse Model of Behcet's Disease Induced by HSV Inoculation
… is a nonclassical class I MHC molecule. HLA-G interacts with different natural killer (NK) cell receptors and is able to inhibit NK and T-cell cytotoxicity, as well as T-cell proliferation. An HLA-G 3741_3754 14-base pair insertion allele was significantly more frequent in Behcet's disease …
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Genetic and Chemical Genetic Approaches to Shiga Toxin Inhibition
Infection with Shiga toxin-producing bacteria can place patients at risk of developing hemolytic uremic syndrome, a toxemic condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Though hemolytic uremic syndrome remains the leading cause of acute renal failure in …
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On the discovery and biological characterization of porcine β-Defensin 5 (pBD-5)
Feeding an ever-growing population, antimicrobial resistance (AMR) and infection control are among the biggest challenges humanity faces in the XXI century. Host defense peptides (HDPs), such as porcine β-defensins (pBDs), have gained attention for their immunomodulatory, microbiome-modulating, and …
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UNDERSTANDING PLACENTAL IMMUNITY: CYTOKINE CONTROL OF CONGENITAL VIRAL INFECTION
During the critical developmental period of pregnancy, there are substantial consequences to viral infection. Following maternal infection, certain viruses can traverse the placental barrier, establish infection in the fetus, and cause adverse pregnancy outcomes or congenital disease. To combat …
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Hear Today, Gone Tomorrow: Exploring Quinoxaline Derivatives as a Treatment for Noise-Induced Hearing Loss
According to the World Health Organization, there are 1.3 billion people around the world living with some degree of noise-induced hearing loss (NIHL) and 1 billion young adults at risk of developing NIHL. Currently, there are no FDA-approved drugs that protect the inner ear against NIHL. To …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the disease and thus design more suitable therapeutic options. …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… poorly to available treatment options. As most individuals diagnosed with these tumors succumb to the disease within about 2 years of diagnosis, it is imperative to develop a more thorough understanding of molecular mechanisms of the disease and thus design more suitable therapeutic options. …
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Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
… those with some mutations over others, creating a dynamic heterogeneous system made up of different cell populations, called sub-clones. This heterogeneity poses a challenge for treatment, as this variety serves to ensure there is almost always a portion of the cells which are resistant to …
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A strategy to suppress STAT1 signalling conserved in pathogenic poxviruses and paramyxoviruses
Vaccinia virus (VACV) is a member of the poxviridae, a family of viruses with large double-stranded, linear DNA genomes that replicate in the cytoplasm of cells. The genome of vaccinia encodes over 200 proteins, many of which have been shown to function as inhibitors of the innate immune response. …
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Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration
Ischaemic heart disease is the leading cause of death globally, with post-myocardial infarction heart failure significantly reducing quality of life and life expectancy. Current treatment strategies focus primarily on alleviating symptoms and reducing the burden on the damaged heart, failing to …
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Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
Conjugated linoleic acid (CLA) has been shown to reduce inflammation via Peroxisome Proliferator-Activated Receptor (PPAR)-γ in inflammatory disorders such as Crohn's Disease and Inflammatory Bowel Disease. We sought to determine whether CLA isomers would reduce inflammation via PPAR-γ in cultured …
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Establishment of new human and mouse liver cancer models and their use to uncover the role of RNF43 and ZNRF3 in liver homeostasis and repair
… worldwide, preceded only by lung cancer. Current models for PLC either fail to fully recapitulate tumour histology and architecture or are expensive, time consuming and do not allow for personalised drug testing. During the first part of my PhD, I have collaborated with Dr. Laura Broutier in order …
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Understanding the role of phages in the mammalian gut microbiome
… that regulates immune responses, defends against pathogens, maintains gut barrier integrity, and modulates metabolic processes. Disruptions of the balanced microbial community, followed by effects on host health, often called dysbiosis, have been associated with alterations in phage …
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Anti-cancer effects of aqueous extracts of Dodonaea Viscosa on Burkitt lymphoma
… Viscosa on Burkitt lymphoma Cancer is a leading public health problem worldwide, and although modern treatments have undeniably improved patient outcomes, many cancers remain refractory or untreatable. New and more effective treatments are needed, and natural phytochemical compounds are a …
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