Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 175 for “"in vivo models"”.
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Developing In Vitro and In Vivo Models for Lyme Neuroborreliosis (LNB)
… (LNB) is a neurologic disorder caused by infection with Borrelia burgdorferi, resulting in inflammation in the central and peripheral nervous systems. LNB remains poorly understood due to the lack of a suitable experimental model. The non-human primate model for LNB presents significant …
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Investigating the role of mitochondrial Ca2+ in in vivo models of neurodegenerative diseases
Neurodegenerative diseases (NDs) such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Frontotemporal dementia (FTD) and Huntington’s disease (HD) represent a significant and growing burden on society and healthcare worldwide. This challenge is exacerbated by the limited understanding of the …
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Investigating the role of mitochondria in the hypoxia response using in vitro and in vivo models
Human coiled-coil helix coiled-coil helix domain-containing protein 4 (CHCHD4) catalyses disulfide bond formation in substrate proteins, mediating their import from the cytoplasm into the mitochondria. CHCHD4 is critical for maintaining intracellular oxygenation and metabolism in human cells, …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
… (HDAC) shift the balance towards chromatin condensation and silence gene expression. Aberrant recruitment of HDACs to alter transcription suggests the use of HDAC inhibitors (HDAC-Is) as potential therapeutic candidates for neurodegenerative disorders such as Parkinson’s disease (PD). …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
Osteopontin (OPN), a glycosylated phosphoprotein found in brain, is reduced in the surviving dopamine-containing neurons in the SN (SN) in Parkinson’s disease (PD). OPN prevents the death of dopaminergic neurons in cell culture and animal models of PD. This effect may be mediated through …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
Cache Valley virus (CVV) is an emerging mosquito-borne orthobunyavirus of significant concern to One Health. CVV was first isolated from Culiseta inornata mosquitoes in Cache Valley, Utah in 1956 and has sporadically emerged to cause epizootics in livestock, particularly affecting small ruminants. …
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Effects of combined exposure to ethanol and ionizing radiation on the antioxidant status of in vitro and in vivo models
"Ethanol and ionizing radiation exposure are independently known to cause tissue damage through various mechanisms. Non-enzymatic and enzymatic metabolism of ethanol, the latter via the cytochrome P₄₅₀2E1-dependent pathway, produces free radicals which deplete cellular glutathione (GSH). Ionizing …
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Saffron extract and its active constituents as preventative and/or treatment agents for prostate cancer using in vitro and in vivo models
… and/or treatments for prostate cancer. Different models of prostate cancer (in vitro and in vivo) were used for studying saffron and its constituents’ mechanisms. In normal prostate cells, saffron extract, crocetin, and safranal, in non-toxic concentrations, possessed antioxidant properties …
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Phenotypic characterisation of wild type and mutant strains of adherent invasive Escherichia coli and Shigella, in vitro, ex vivo and in vivo models
Crohn's disease (CD) is an inflammatory bowel disease (IBD) that is largely the result of aberrant immune responses, such as the increased production of proinflammatory cytokines including IL-1, TNF-ɑ, IFN- ɣ to microbial infections in genetically susceptible individuals.;Adherent-invasive …
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Metabolic and functional approaches to investigate the effects of cytokines on the physiology of in-vitro and in-vivo models of diabetic retinopathy
Diabetic retinopathy (DR) is the leading cause of vision impairment in working age adults worldwide. It is clinically described as hyperglycemia-induced retinal blood vessel damage and is categorized into early non-proliferative and late proliferative stages. Although DR becomes clinically evident …
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Production, characterization and evaluation of anti-diabetes peptides from proteins of improved common bean (Phaseolus vulgaris L.) cultivars using bioinformatic tools, enzymatic systems, and in vitro and in vivo models
… is an important metabolic disease expected to increase worldwide 55% by 2035; with an estimated healthcare cost of $245 billion per year in the US alone. The use of alternative plant based treatments has the advantage of no side effects and could reduce treatment cost. Common beans health …
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Analysis of the behavioural effects of barley and sertraline in two in-vivo models of stress.Anti-depressant and anti-nociceptive effects of barley in mice and sertraline effects on anxiety in the offspring of prenatally-stressed rats
… depression model, the antidepressant sertraline, was assessed in rat mothers (n=14) divided into Prenatally Stressed (PS) and Non-Stressed (NS) groups. The data failed to support the hypothesis that ‘the progeny of 10mg of sertraline-treated PS mothers displayed less anxiety than the progeny …
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Unbalancing Polycomb group proteins activities during liver homeostasis and tumour formation
Increasing evidence demonstrated that mutations altering the activity of chromatin-modifying complexes significantly contribute to liver tumour formation and progression. Inactivating mutations of members of the polycomb complexes have been found in a subset of aggressive HCCs, mainly affecting …
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Tools for Monitoring and Modulating Cellular Communication
… possess the ability to sense and change in response to diverse stimuli. This creates a spatially and temporally dynamic environment, presenting a barrier to investigation and intervention. As such, interfacing with living systems demands precision and adaptability. Here, we present novel …
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Macrophages in vitro as a predictive model in polymer toxicology
… 1, Polymer 2 and Polymer 3, respectively) of varying toxic potential, designed for use in cosmetic aerosols, were used as model substances to predict inflammatory potential. In vivo inflammogenic potential was evaluated by assessment of inflammatory cell profile (alveolar macrophage (AM), …
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THREE DIMENSIONAL IN VITRO MODEL OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Head and neck squamous cell carcinomas (HNSCC) are among the leading causes of cancer related deaths throughout the world. The survival rate for this type of cancer is extremely low and has not changed significantly in recent decades. There is an imperative need to study tumor progression in a …
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… viruses (OV) are a strong contender. OVs interact with immune components of the TME, which can be altered due to specific genetic mutations. The present study evaluates the impact of specific tumour mutations on the response to carboplatin, the current standard of care, and VSV∆M51, a …
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Development of a hydrogel-based microfluidic model of the lymph node
… meet to mount antigen specific immune responses. In cancers, the tumour-draining lymph node (TDLN) is the site of initial anti-tumour immune response. The TDLN undergoes dramatic reprogramming in response to tumour drainage that is still partly unclear. In vivo models do not easily permit us to …
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… project aimed to provide a mechanistic understanding of the effect of endoplasmic reticulum (ER) stress on the differentiation of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. …
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