Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 154 for “"in vivo model"”.
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Development of an inducible psoriasis-like in vivo model
Psoriasis is a common chronic inflammatory skin condition. Several key mediators have been identified to play a role in the pathogenesis of this disease including PPARd and STAT3. PPARd is a member of the Peroxisome Proliferator Activator Receptor family and has been implicated in psoriasis, as …
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Characterization of an in Vivo Model of Temporomandibular Joint Inflammation
Activation of trigeminal nerves is involved in temporomandibular joint (TMJ) inflamation and pain transmission. The proinflammatory molecule nitric oxide (NO) and protons are implicated in the underlying pathology of temporomandibular joint disorders. The goal of this study was to investigate gap …
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Cerebral blood flow in the non-human primate : an in vivo model and drug interventions
… dynamics is an essential component for preserving cerebral integrity. Cerebral blood flow abnormalities are often seen in patients with central nervous system pathologies such as epilepsy, migraine, Alzheimer's Disease, vascular dementia, stroke, and even HIV/AIDS. There is increasing clinical …
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The Influence of Age, Gender, and Thiol Repletion in an In Vivo Model of Lewy Body Disorders
… body disorders are a family of neurological brain disorders associated with olfactory, motor, and cognitive deficits and are collectively defined as α-synucleinopathies, as they are characterized by hallmark “Lewy bodies” composed of aggregated, fibrillar α-synuclein. It is not certain but often …
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Drosophila melanogaster as a high-throughput and in vivo model to study body weight and feeding behaviour
… challenges of the 21st century. Whilst the increase in prevalence has been driven by changes in lifestyle and environment, it is clear that there is a genetic component underlying the variation in body weight between individuals. However, the speed of translating obesity genetics into …
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Developing Zebrafish as an In Vivo Model to Screen Compounds for Anti-Cancer Activity in Human Breast Cancer
… cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. Discovery and development of safe and effective …
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
… of the most common causes of death from disease in children. Broad-range drug resistance is often associated with relapse, although its underlying molecular mechanisms remained poorly understood. The aim of this thesis was to establish an in vivo model using the non-obese diabetic/severe combined …
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Analysis of gamma secretase regulation by phosphatidylethanolamine using mammalian and Drosophila melanogaster in vitro and in vivo model systems
… peptide (A?), that plays a central role in the pathogenesis of Alzheimer’s disease is derived by sequential proteolytic processing from the amyloid precursor protein (APP) by ?- and ?-secretase. APP is additionally processed through a non-amyloidogenic pathway by ?-secretase. Recent work …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
<p>Temporomandibular joint disorder (TMJD) pathology involves activation of primary nociceptive neurons that promote peripheral sensitization and excitation of second order neurons implicated in the development of central sensitization and hyperalgesia. Elevated levels of the neuropeptide …
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Investigations into the stability of growth factor induced-vasculature and the effects of synthetic biomaterials on heart remodelling after myocardial infarction
… of growth factor delivery rate and duration, combined with a biomaterial scaffold, could lead to an improved strategy for therapeutic neovascularization. To test this hypothesis, a novel in vivo model system that allows for characterization of stability and mural cell investment of newly created …
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The development of an in vivo nerve-muscle model in the rat : and an experiment "The interaction between rocuronium and thiopentone" to test the validity of the model
Experimentation involving small animals has, over the years, been of major importance in the development of our current understanding of nerve - muscle physiology. This dissertation describes the development of an in vivo model of the rat nerve interface at the Faculty of Health Sciences at the …
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
In the central nervous system (CNS), microglial cells are neuroimmune cells that act as the brain’s sentinel macrophages to protect and maintain a homeostatic functional state for a healthy brain. In this thesis, I will discuss how neuroimmune microglial cells contribute to systemic metabolic …
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Disease-modifying effects of human small heat shock proteins in zebrafish models of neurodegeneration
… characterised by the build-up of misfolded proteins and degeneration of brain structures. Tauopathies are a collective of >20 such diseases featuring abnormally aggregating tau, a microtubule-associated protein normally acting to stabilise these protein cargo tracks. There is currently no cure. …
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Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
In this study, adaptation of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional …
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Exploring the role of Wnt signalling in heart failure with preserved ejection fraction.
According to the European Society of Cardiology long-term out-patient registry, heart failure with preserved ejection fraction (HFpEF) accounts for approximately 16% of heart failure cases, with survival rates failing to improve due to the lack of effective treatments and the increasing prevalence …
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Effects of combined exposure to ethanol and ionizing radiation on the antioxidant status of in vitro and in vivo models
"Ethanol and ionizing radiation exposure are independently known to cause tissue damage through various mechanisms. Non-enzymatic and enzymatic metabolism of ethanol, the latter via the cytochrome P₄₅₀2E1-dependent pathway, produces free radicals which deplete cellular glutathione (GSH). Ionizing …
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Untersuchungen HLA-Klasse II-assoziierter, T-zellvermittelter Autoimmunität im humanisierten SCID-Mausmodell des Pemphigus vulgaris
… vulgaris (PV) is a severe bullous autoimmune skin disease which is caused by autoantibodies against an epidermal adhesion protein, desmoglein 3 (DG3). The underlying cellular mechanisms in the pathogenesis of PV are not yet completely understood. PV is associated with particular HLA class II …
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Discovery of Novel Mechanisms Regulating Cancer Extravasation in the Chorioallantoic Membrane Model
Cancer metastasis is a multistep process that begins with the invasion of tumour cells into the stroma and migration towards the blood vessels. Tumour cells that have entered the bloodstream must then survive and leave by a process known as extravasation. Finally, extravasated cells proliferate and …
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Matrix metalloproteinases in the equine systemic inflammatory response: implications for equine laminitis
Laminitis is a crippling and often life-threatening disease of the equine foot. Soft tissue damage characteristic of this disease has been associated with increased MMP activity. Therefore, it seems likely that MMPIs could be potential therapeutic agents for laminitis. Further characterization of …
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Characterization of human adipose tissue-derived adult multipotent precursor cells
… of a putative subpopulations of stem cells in the adipose tissue stroma. These adipose derived stem cells (ADSCs) under certain conditions express characteristics of various mesenchymal lineages. This thesis showed that 1,25a??dihydroxyvitamin D3 worked synergistically with …
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