Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"in vivo loading"”.
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Ex Vivo Deformations of the Uterosacral Ligaments
… structures that support the uterus and apical vagina within the pelvis. As these structures are over-stretched, become weak, and exhibit laxity, pelvic floor disorders such as pelvic organ prolapse occur. Although several surgical procedures to treat pelvic floor disorders are directed toward the …
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Towards an Intelligent Intervertebral Disc Prosthesis for the Assessment of Spinal Loading
Low back pain is an economic and social burden to society. Low back pain is considered to be a chronic problem when the causes are due degenerative disc diseases and damaged vertebrae. The main causes for degenerative disc are extremely complex and still not well understood, although in their …
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Chondrocyte gene expression and intracellular signaling pathways in cartilage mechanotransduction
Chondrocytes respond to in vivo mechanical loads by regulating the composition of the cartilage extracellular matrix. This study utilized three loading protocols that span the range of forces and flows induced by in vivo loading. Constant (static) compression of cartilage explants induces a …
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Chondrocyte metabolism and matrix nano-electromechanics : the response to cartilage tissue shear deformation
Cartilage functions as a load bearing and friction reducing material in synovial joints and it is constantly exposed to in vivo loading which is coupled to electromechanical and physicochemical forces. The swelling pressure of cartilage originates from proteoglycans containing negatively charged …
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Musculoskeletal Modeling of The Human Elbow Joint
Comprehensive knowledge of the in vivo loading of elbow structures is essential in understanding the biomechanical causes associated with elbow diseases and injuries, and to find appropriate treatment. Currently, in vivo measurements of ligament, and muscle forces, and cartilage contact pressures …
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Influence of Mechanical Stimulation on the Quantity and Quality of Bone During Modeling
… estimated 1.5 million Americans per year, creating a large economic burden on our society. Treatment of bone diseases prior to fracture often involves bisphosphonates (current gold-standard in osteoporosis care and prevention). Although bisphosphonates decrease fracture incidence, they often …
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Analyzing large-scale chromatin fiber via studying cytology of DNA replication and in vivo immunogold labeling
The structure of interphase chromosomes remains elusive after decades of research by using chemical, physical and biological methods. Although large-scale interphase chromatin has been observed repeatedly, its high-order compaction level is hard to reconcile with its active biological functions, …
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Analysis and design of an adjustable bone plate for mandibular fracture fixation
This thesis presents the design, analysis and testing of a bone plate for mandibular fracture fixation. Conventional bone plates are commonly used to set fractures of the mandible in a surgical setting. If proper alignment between the two bone segments is not achieved, then a malocclusion can …
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The effect of manipulating apoptotic cell uptake on their immunogenicity
… of homeostasis prevents a successful response being mounted against tumours. Apoptotic cells are cleared rapidly by professional phagocytes thus preventing the release of potentially inflammatory or immunogenic material into the surrounding environment. In addition, macrophages release …
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Investigation of spine loading to understand vertebral fractures
… and are associated with significant pain, height loss, disfigurement, respiratory impairment, depression, and decreased life span. Despite the high personal and societal costs of vertebral fractures, little is known regarding their biomechanical etiology. In particular, whereas much is …
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Estimation of in-vivo forces within Anterior Cruciate Ligament in response to increased weightbearing
… of Anterior Cruciate Ligament (ACL) forces in-vivo is instrumental for understanding ACL injury mechanisms and for improvement of surgical ACL reconstruction. The goal of this thesis was to develop and implement a non-invasive method to determine the ACL forces under physiological loading …
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Mechanical Characterization of Swine Uterosacral and Cardinal Ligaments
The uterosacral ligament (USL) and cardinal ligament (CL) are the two major suspensory tissues of the uterus, cervix, and vagina. These supportive structures can be weakened or damaged, leading to the development of pelvic floor disorders (PFDs) such as urinary incontinence, fecal incontinence, and …
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Biaxial Mechanical Evaluation of Uterosacral and Cardinal Ligaments
The uterosacral ligament (USL) and the cardinal ligament (CL) are two major suspensory tissues that provide structural support to the vagina/cervix/uterus complex. These ligaments have been studied mainly due for their role in the surgical repair for pelvic organ prolapse (POP). POP, which is the …
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The Development and Application of a Custom Robotic Biomechanical Testing Platform Employing Real-time Load-control to Compare Spinal Biomechanical Testing Protocols: Pure Moment, Ideal Follower Load, and a Novel Trunk Weight Protocol
<p>The human lumbar spine has been the subject of biomechanical study for many decades owing to the numerous medical cases resulting in the development of various corrective surgical procedures and medical devices intended to relieve patient discomfort. Spinal biomechanics is a broad field …