Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"in vivo experimentation"”.
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The racial disparities of the Gamma-secretase/Notch pathway and inhibition in triple negative breast cancer
<p>Triple Negative Breast Cancer (TNBC) continues to be a formidable challenge in oncology, characterized by its aggressive phenotype and limited treatment options. Alarming racial disparities in TNBC outcomes persist, with underrepresented populations experiencing disproportionately higher rates …
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Prevalence and prevention of large-scale somatic copy number alterations
Organismal viability is contingent upon the transmission of a balanced genome to the next generation. Genomic imbalance on the order of megabases, as occurs with sub-chromosome copy number variants (CNVs) or whole-chromosome aneuploidy, is almost always associated with embryonic lethality or severe …
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Controlled release of gentamicin from polyelectrolyte multilayers to treat implant-related infection
Polyelectrolyte multilayered (PEM) coatings were fabricated to incorporate and release the small, hydrophilic antibiotic gentamicin from implant surfaces for infection control. The use of a cationic hydrolytically cleavable poly(p-amino ester) rendered these films biodegradable, yielding both …
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Application of capillary zone electrophoresis methods for the investigation of in vitro drug metabolism.
… chromatography (HPLC) has for some time been the industry standard in pharmaceutical analysis. A diverse choice of column packing materials enables a wide range of analytical separations to be performed, including both normal and reversed phase as well as chiral chromatography. A variety of …
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Genetic Regulation of Müllerian Duct Regression
<p>Mammals, including humans, develop progenitor tissues for both male and female reproductive tract organs before they fully differentiate into a male or female tract. The progenitor tissue for the male reproductive tract is known as the Wolffian duct (WD), and the progenitor tissue for the female …
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Physical and biological characterisation of clinically relevant combined MRI-radiation exposures with conventional and nanoparticle contrast agents
Background:<br/>MR-Linacs provide a unique opportunity for MRI contrast agents to be investigated, not only for the ability to enhance contrast, but for their potential radiosensitising properties to improve radiotherapy treatments. Metal-based nanoparticle contrast agents have a preferential …
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Developing a stem-cell system of embryonic development organised by a morphogen signaling centre
… dependent on the precise communication and coordination from both the embryonic and extraembryonic tissues. These interactions ensures that the tissues become spatially localized within the embryo for the process of gastrulation, a pivotal event whereby the three germ layers: mesoderm, endoderm, …
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A Mechanical and Histological Study of Functionally Graded Hydroxyapatite Implant Coatings
<p>Ever since Dr. Brånemark discovered that titanium was biocompatible with bone, extensive research has been done to improve the osseointegration of dental implants. As advances in medicine continue, the average life span of the population is ever increasing. Today, people of all ages are …
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In vitro evaluation of nutritional content and anthelmintic values of Kigelia africana fruit to domesticated ruminants
Food security is at risk due to the ever growing world population. More effort should be put on improving agricultural production since farming provides the primary source of food for humans. Livestock farming; be it commercial or small scale, plays a major role in supplementing the protein …