Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"in vivo Monitoring"”.
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Spectroscopy versus turbidity: non-invasive in vivo monitoring of living systems
… aim is to advance the use of light for noninvasive monitoring of living systems generally defined. We first describe work used to test a methodology for real-time probing of chemical and physical changes in spinal cords in the immediate aftermath of a localized contusive injury by way of …
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Cerebral Hemodynamics and Its Oxygenation: Study of Their Baseline and Spontaneous Oscillation
Near infrared spectroscopy (NIBS) has been used for determination of tissue optical properties. This technique has been especially useful for in vivo monitoring of hemodynamics and oxygen saturation in tissue. For this work, I have developed a large-ranged multidistance probe for NIBS, which allows …
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Systems approaches to identify molecular signatures from high-throughput expression data: towards next generation patient diagnostics
… of virtually all molecular components within human cells, tissues, organs, and serum has led to the generation of a tremendous amount of raw information. However, converting large-scale data to essential knowledge on human health and disease mechanisms has been a significant challenge thus …
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Modeling of [¹⁸F]-FHBG in tumor and normal tissues
The development of new, non-invasive approaches for the treatment of tumors has led to the emergence of oncolytic virus therapy. Viruses have been engineered to preferentially target tumor cells. The efficiency and safety of this cancer treatment is dependent upon selective viral replication within …
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Analysing the role of SAL1/PAP retrograde signalling within the circadian system of Arabidopsis thaliana
Plants have developed an internal timing mechanism, the circadian system, that serves to synchronise physiological and metabolic functions with daily, predictable cues such as dawn and dusk. This endogenous oscillator is comprised of biochemical and transcriptional rhythms that are entrained by …
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Electrochemistry of Amorphous Carbon Based Materials - Development of an electrochemical sensor for the detection of dopamine
… of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, will continue to increase as the population ages. This is expected to impose an increasing social and economic burden on societies. Parkinson's disease is characterized mainly by motor symptoms that are caused by …
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Ultrahigh-Resolution Endoscopic Optical Coherence Tomography for In Vivo Mouse Colonoscopy
In vivo monitoring of mouse models of colon cancer promises to reduce the cost of research by improving sacrifice timing and allowing serial studies that observe the progression of disease and drug efficacy in a relatively small set of animals. Optical coherence tomography (OCT) is an optical …
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BEYOND ARABIDOPSIS: UNRAVELLING THE HIDDEN WORLD OF CA2+ SIGNALLING ACROSS SPECIES VIA MULTISCALE IMAGING TECHNOLOGIES
Confined to the site of germination, vascular plants evolved precise mechanisms to perceive and respond to environmental stimuli. Over the last decades, to in vivo investigate these processes both biological tools and imaging technologies have rapidly evolved. In particular, the use of Genetically …
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Entwicklung eines GFP-Reportersystems in Legionella und molekularbiologische Funktionsanalyse des Legionella Mip-Proteins
Das fakultativ intrazelluläre Bakterium Legionella pneumophila wurde erstmals 1977 als Erreger der Legionellose, einer schweren atypisch verlaufenden Pneumonie identifiziert. Es besitzt ein duales Wirtssystem und kann sich sowohl in aquatischen Habitaten in Protozoen als auch in phagozytierenden …
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The Design, Development and Characterisation of a new Biosensor for In-vivo Neurochemical Monitoring of ᴅ-Serine
The desire to monitor important neurotransmitters in the in vivo environment, in real-time and in conscious subjects has been the driving force behind the continued development over the last 40 years of a range of biosensor devices. This is a none too difficult task considering the milieu of …
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MRI and NMR Investigations of Transport in Soft Materials and Explorations of Electron-Nuclear Interactions for Liquid-State Dynamic Nuclear Polarization
… for polymeric material characterizations in solutions, with emphasis on methods utilizing magnetic field gradients - magnetic resonance imaging (MRI) and pulsed-field-gradient (PFG) NMR. The second part (Chapter 5) presents enhancements to dynamic nuclear polarization, an intensity …